Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Epithelial cadherin (E-cadherin) is a classic tumor suppressor gene of the cadherin superfamily and its promoter region is usually hypermethylated in malignant carcinomas.
|
30390382 |
2019 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Endoscopic screening in HDGC families without a pathogenic CDH1 mutation may be reasonable, as we detected signet ring cell carcinomas in 6% of persons screened.
|
28455161 |
2018 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
CDH1 germline mutations lead to hereditary diffuse gastric carcinomas.
|
29168119 |
2018 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We found high epithelial marker expressions (CK8/18, E-cadherin, membranous β-catenin) only in a distinct variety of carcinomas.
|
27729431 |
2017 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A comprehensive search using the keywords "CDH1," "E-Cadherin," "polymorphism," "SNP," and "variant" combined with "breast," "cancer," "tumor," or "carcinomas" was conducted.
|
27349965 |
2016 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant.
|
26901067 |
2016 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
As TP53 mutation and CDH1 inactivation occur in 80% of human endometrial type II carcinomas, we hypothesized that mouse uteri lacking both Trp53 and Cdh1 would exhibit a phenotype indicative of neoplastic transformation.
|
24998851 |
2015 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Epithelial-cadherin (Ecad) deregulation affects cell-cell adhesion and results in increased invasiveness of distinct human carcinomas.
|
26246502 |
2015 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Some signet ring cell carcinomas have been found to have mutations in the E-cadherin gene, which fits the above hypothesis.
|
25019985 |
2014 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Ongoing research focus on the search of genetic causes other than CDH1 or CTNNA1 germline defects; assessment of the pathogenicity and penetrance of CDH1 missense mutations and identification of somatic mechanisms behind the progression from early (indolent) lesions to invasive (lethal) carcinomas.
|
25439071 |
2014 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Cadherin-1 (CHD1), as an invasion suppressor gene, could suppress tumor cell invasion and metastasis in various tumors, but reduced CHD1 levels, resulting from epigenetic silencing, are common in poorly differentiated, advanced stage carcinomas.
|
24952891 |
2014 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Synchronous appendiceal and intramucosal gastric signet ring cell carcinomas in an individual with CDH1-associated hereditary diffuse gastric carcinoma: a case report of a novel association and review of the literature.
|
23849133 |
2013 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Disruption of E-cadherin (CDH1 gene) expression, subcellular localization or function arises during initiation and progression of almost 90% of all epithelial carcinomas.
|
22752307 |
2012 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Reduced epithelial cadherin (E-cad) is a hallmark of invasive carcinomas that have acquired epithelial-mesenchymal transition (EMT) phenotypes.
|
21613543 |
2011 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Expression of the nuclear factor ZEB1 induces an epithelial-to-mesenchymal transition and confers a metastatic phenotype on carcinomas by repressing the E-cadherin gene at the transcriptional level.
|
20418909 |
2010 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
This study was conducted to evaluate the promoter methylation status of p16(INK4a) and E-cadherin genes in 22 specimens of cervical carcinomas, four cervical cancer cell lines (HeLa, SiHa, Caski, C33A), and 20 human papillomavirus negative specimens, obtained from normal cervical swabs, using the methylation-specific PCR approach.
|
20112504 |
2009 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Large numbers of stage T1a signet ring cell carcinomas exist in the stomachs of CDH1 mutation carriers from a young age, and these foci sometimes show enrichment to the transition zone between the body and antrum.
|
19432899 |
2009 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Association of CDH1 single nucleotide polymorphisms with susceptibility to esophageal squamous cell carcinomas and gastric cardia carcinomas.
|
18197935 |
2008 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We evaluated E-cadherin protein expression by immunohistochemistry in pancreatobiliary cancers having a noncohesive histologic phenotype (21 undifferentiated adenocarcinomas and 7 signet ring carcinomas), comparing the results with pancreatic cancers having a cohesive phenotype (25 moderately differentiated and 14 poorly differentiated adenocarcinomas).
|
18223216 |
2008 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Distinct pattern of allelic loss and inactivation of cadherin 1 and 5 genes in mammary carcinomas arising in p53(+/-) mice.
|
17327688 |
2007 |
Carcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Mutations in the epithelial cadherin (E-cadherin) gene have been shown to be associated with the occurrence of diffuse gastric carcinomas in affected families.
|
17609302 |
2007 |
Carcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma.
|
17520682 |
2007 |
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
In this study, CDH1 promoter hypermethylation was observed in 54.8% (46/84) of the analyzed sporadic gastric carcinomas.
|
16531765 |
2006 |
Carcinoma
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Helicobacter pylori infection in relation to E-cadherin gene promoter polymorphism and hypermethylation in sporadic gastric carcinomas.
|
16127748 |
2005 |
Carcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas.
|
16316942 |
2005 |