CDH1, cadherin 1, 999

N. diseases: 508; N. variants: 187
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 PosttranslationalModification group BEFREE Epithelial cadherin (E-cadherin) is a classic tumor suppressor gene of the cadherin superfamily and its promoter region is usually hypermethylated in malignant carcinomas. 30390382 2019
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 GeneticVariation group BEFREE Endoscopic screening in HDGC families without a pathogenic CDH1 mutation may be reasonable, as we detected signet ring cell carcinomas in 6% of persons screened. 28455161 2018
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 GeneticVariation group BEFREE CDH1 germline mutations lead to hereditary diffuse gastric carcinomas. 29168119 2018
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group BEFREE We found high epithelial marker expressions (CK8/18, E-cadherin, membranous β-catenin) only in a distinct variety of carcinomas. 27729431 2017
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 GeneticVariation group BEFREE A comprehensive search using the keywords "CDH1," "E-Cadherin," "polymorphism," "SNP," and "variant" combined with "breast," "cancer," "tumor," or "carcinomas" was conducted. 27349965 2016
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 GeneticVariation group BEFREE Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. 26901067 2016
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 GeneticVariation group BEFREE As TP53 mutation and CDH1 inactivation occur in 80% of human endometrial type II carcinomas, we hypothesized that mouse uteri lacking both Trp53 and Cdh1 would exhibit a phenotype indicative of neoplastic transformation. 24998851 2015
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group BEFREE Epithelial-cadherin (Ecad) deregulation affects cell-cell adhesion and results in increased invasiveness of distinct human carcinomas. 26246502 2015
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 GeneticVariation group BEFREE Some signet ring cell carcinomas have been found to have mutations in the E-cadherin gene, which fits the above hypothesis. 25019985 2014
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 GeneticVariation group BEFREE Ongoing research focus on the search of genetic causes other than CDH1 or CTNNA1 germline defects; assessment of the pathogenicity and penetrance of CDH1 missense mutations and identification of somatic mechanisms behind the progression from early (indolent) lesions to invasive (lethal) carcinomas. 25439071 2014
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 AlteredExpression group BEFREE Cadherin-1 (CHD1), as an invasion suppressor gene, could suppress tumor cell invasion and metastasis in various tumors, but reduced CHD1 levels, resulting from epigenetic silencing, are common in poorly differentiated, advanced stage carcinomas. 24952891 2014
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 GeneticVariation group BEFREE Synchronous appendiceal and intramucosal gastric signet ring cell carcinomas in an individual with CDH1-associated hereditary diffuse gastric carcinoma: a case report of a novel association and review of the literature. 23849133 2013
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 AlteredExpression group BEFREE Disruption of E-cadherin (CDH1 gene) expression, subcellular localization or function arises during initiation and progression of almost 90% of all epithelial carcinomas. 22752307 2012
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group BEFREE Reduced epithelial cadherin (E-cad) is a hallmark of invasive carcinomas that have acquired epithelial-mesenchymal transition (EMT) phenotypes. 21613543 2011
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group BEFREE Expression of the nuclear factor ZEB1 induces an epithelial-to-mesenchymal transition and confers a metastatic phenotype on carcinomas by repressing the E-cadherin gene at the transcriptional level. 20418909 2010
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group BEFREE This study was conducted to evaluate the promoter methylation status of p16(INK4a) and E-cadherin genes in 22 specimens of cervical carcinomas, four cervical cancer cell lines (HeLa, SiHa, Caski, C33A), and 20 human papillomavirus negative specimens, obtained from normal cervical swabs, using the methylation-specific PCR approach. 20112504 2009
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 GeneticVariation group BEFREE Large numbers of stage T1a signet ring cell carcinomas exist in the stomachs of CDH1 mutation carriers from a young age, and these foci sometimes show enrichment to the transition zone between the body and antrum. 19432899 2009
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 GeneticVariation group BEFREE Association of CDH1 single nucleotide polymorphisms with susceptibility to esophageal squamous cell carcinomas and gastric cardia carcinomas. 18197935 2008
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 AlteredExpression group BEFREE We evaluated E-cadherin protein expression by immunohistochemistry in pancreatobiliary cancers having a noncohesive histologic phenotype (21 undifferentiated adenocarcinomas and 7 signet ring carcinomas), comparing the results with pancreatic cancers having a cohesive phenotype (25 moderately differentiated and 14 poorly differentiated adenocarcinomas). 18223216 2008
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 GeneticVariation group BEFREE Distinct pattern of allelic loss and inactivation of cadherin 1 and 5 genes in mammary carcinomas arising in p53(+/-) mice. 17327688 2007
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 GeneticVariation group BEFREE Mutations in the epithelial cadherin (E-cadherin) gene have been shown to be associated with the occurrence of diffuse gastric carcinomas in affected families. 17609302 2007
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group CTD_human Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma. 17520682 2007
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 PosttranslationalModification group BEFREE In this study, CDH1 promoter hypermethylation was observed in 54.8% (46/84) of the analyzed sporadic gastric carcinomas. 16531765 2006
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 PosttranslationalModification group BEFREE Helicobacter pylori infection in relation to E-cadherin gene promoter polymorphism and hypermethylation in sporadic gastric carcinomas. 16127748 2005
CUI: C0007097
Disease: Carcinoma
Carcinoma
0.400 Biomarker group CTD_human Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. 16316942 2005