CDH1, cadherin 1, 999

N. diseases: 508; N. variants: 187
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 Biomarker disease BEFREE The cadherin 1 (<i>CDH1</i>) gene plays critical roles in the epithelial-mesenchymal transition process, potentially offering us a glimpse into the development of endometrial carcinoma (EC). 30405831 2018
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 Biomarker disease BEFREE Finally, six UCEC-related triplets were selected in which the mRNA participates in endometrial carcinoma pathway, such as CDH1 and TP53. 28280730 2017
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 Biomarker disease BEFREE Knocking-down Cdh1 in ECA cell lines increased Skp2/Cks1 E3 ligase activity, completely diminished nuclear and cytoplasmic p27, and obviated TGF-β-mediated inhibition of proliferation. 26963853 2016
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 AlteredExpression disease BEFREE The role of WWOX tumor suppressor gene in the regulation of EMT process via regulation of CDH1-ZEB1-VIM expression in endometrial cancer. 25892250 2015
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 Biomarker disease BEFREE Mice with conditional ablation of Cdh1 and Trp53 (Cdh1(d/d)Trp53(d/d)) clearly demonstrate architectural features characteristic of type II ECs, including focal areas of papillary differentiation, protruding cytoplasm into the lumen (hobnailing) and severe nuclear atypia at 6 months of age. 24998851 2015
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 PosttranslationalModification disease BEFREE No associations were noted between promoter hypermethylation of the CDH1 gene and biological features of the endometrial cancer cases. 24068440 2013
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 AlteredExpression disease BEFREE Overexpression of the OCT4 protein in primary human endometriotic stromal cells and human RL95-2 and HEC1A endometrial carcinoma cell lines resulted in decreased levels of E-CADHERIN, the increased expression of the VIMENTIN, TWIST, and SLUG proteins, and an increase in the migration activity of endometrial cells in transwell and wound closure assays. 23290742 2013
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 PosttranslationalModification disease BEFREE Quantitative methylation studies dismissed CDH1 promoter hypermethylation as the mechanism responsible for this change in gene expression, while immunohistochemistry revealed that the E-cadherin repressor ZEB1 was frequently overexpressed (62%) in undifferentiated endometrial carcinomas. 23743934 2013
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 AlteredExpression disease BEFREE All E-cadherin repressors (SNAI1, SNAI2 (SLUG), ZEB1, HMGA2, and TWIST1) had a higher expression in endometrioid endometrial carcinomas than in normal endometrium (P < .0001), whereas CDH1 (E-cadherin gene) tended to be lower. 21940036 2012
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 AlteredExpression disease BEFREE Nude mice with xenografted implants of human EC HEC-1-B cells were treated with valproic acid (VPA) and decitabine (DAC) and evaluated for tumor growth, CDH1 and Bcl-2 mRNA levels. 22343305 2012
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 PosttranslationalModification disease BEFREE We found that the hypermethylation of CDH1 promoter, which caused low expression of E-cadherin in endometrial cancer, was associated with not only clinicopathological progress of endometrial cancer but also with the overall 5-year clinical survival rate. 20874004 2011
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 PosttranslationalModification disease BEFREE Methylation of E-cadherin was found only in EC (22.1%). 19900189 2010
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 PosttranslationalModification disease BEFREE This is the first report to analyze methylation of the E-cadherin gene promoter of endometrial carcinoma and the evidence suggests that methylation of the E-cadherin gene occurs in association with the acquisition of invasive capacity. 12569599 2003
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 PosttranslationalModification disease BEFREE Suppression of gap junctional intercellular communication via 5' CpG island methylation in promoter region of E-cadherin gene in endometrial cancer cells. 12896902 2003
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 PosttranslationalModification disease BEFREE CDH1 promoter hypermethylation was found in 21.2% of endometrial carcinomas but was not associated with clinicopathological or immunohistochemical variables. 12635138 2003
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 Biomarker disease CTD_human Mutations of the E-cadherin gene in human gynecologic cancers. 8075649 1994
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 Biomarker disease HPO
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.700 CausalMutation disease CLINVAR