Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Endoscopic Ultrasound Has Limited Utility in Diagnosis of Gastric Cancer in Carriers of CDH1 Mutations.
|
31077828 |
2020 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of circFNDC3B reduced the level of E-cadherin protein to promote the epithelial-mesenchymal transition in GC.
|
30963578 |
2019 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology.
|
31207149 |
2019 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 somatic alterations in Mexican patients with diffuse and mixed sporadic gastric cancer.
|
30642281 |
2019 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The cumulative incidence of gastric cancer for individuals with pathogenic variants in CDH1 is significantly lower than previously described.
|
31246251 |
2019 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrate that germline CDH1 mutations are a significant contributor to the high frequency of diffuse gastric cancer in New Zealand Māori.
|
29589180 |
2019 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Kras activation and Pten deletion are observed in intestinal-type gastric cancer, and Cdh1 mutation is associated with diffuse-type gastric cancer.
|
30168144 |
2019 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
CDH1 hypermethylation status was found to be associated with advancement of disease, distant organ metastases and lymph node invasion in Gastric cancer patients.
|
30989488 |
2019 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
CDH1a, a non-canonical transcript of the CDH1 gene, has been found to be expressed in some gastric cancer (GC) cell lines, whereas it is absent in normal gastric mucosa.
|
29443099 |
2018 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the CDH1 gene are linked both to diffuse gastric cancer and invasive lobular carcinoma (ILC).
|
28993866 |
2018 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The results revealed that CDH1, cyclooxygenase-2 and matrix metalloproteinase genes had significantly higher expression levels, whereas the expression levels of dermatopontin and transforming growth factor β receptor 2 were decreased in GC samples.
|
29434905 |
2018 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We identified a new truncating germline mutation (p.Asp538Thrfs*19) in exon 11 of the CDH1 gene in a 41-year-old male with a diffuse gastric cancer.
|
29131691 |
2018 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
For the first time, we evaluated by digital PCR the expression of CDH1 and CDH1a transcripts in cancer and normal tissue samples from 32 patients with intestinal-type gastric cancer.
|
27861150 |
2017 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Female predominance in early-onset gastric cancer may be related to relatively high rates of somatic CDH1 and TGFBR1 mutations in this population.
|
28522256 |
2017 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
In addition, methylation of the CDH1 gene in AM may be a surrogate of GC.
|
29042646 |
2017 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
It is implied that TRERNA1/CDH1 is a new potential target for GC therapy.
|
28918030 |
2017 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
HDGC, which is mainly caused by germline mutations in the E-cadherin gene (CDH1), renders a lifetime risk of gastric cancer of up to 70%, prompting a recommendation for prophylactic total gastrectomy.
|
27759617 |
2017 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with hereditary diffuse gastric cancer (HDGC) not associated with mutations in CDH1 and performed whole-exome sequence analysis.
|
28024868 |
2017 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The <i>CDH1</i> gene, coding for the E-cadherin protein, is linked to gastric cancer (GC) susceptibility and tumor invasion.
|
29295527 |
2017 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study was aimed to analyse the hypermethylation status of the E-Cadherin (CDH1) gene promoter in GCs in the ethnic Kashmiri population.
|
27356686 |
2016 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Germline E-cadherin/CDH1 mutations have been identified in families with an autosomal dominant inherited predisposition to diffuse gastric cancer.
|
27899187 |
2016 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the CDH1 c.1679C>G (p.T560R) variant segregated with gastric cancer in all three family members affected with gastric cancer in this family.
|
27880784 |
2016 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The -472delA (rs5030625) and -160C>A (rs16260) polymorphisms in CDH1 induce a decrease in gene transcription; in fact, these mutated alleles have been associated with GC in some populations, with conflicting results.
|
27706737 |
2016 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 germ-line missense mutation identified by multigene sequencing in a family with no history of diffuse gastric cancer.
|
25981591 |
2015 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The risk of development of gastric cancer is high in families affected b-y these syndromes, but only hereditary diffuse gastric cancer is genetically explained (caused by germline alterations of CDH1, which encodes E-cadherin).
|
25638682 |
2015 |