|
Carcinoma, Ovarian Epithelial
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
At 10 % cutoff for CDH1 94% of EOC cases were found to be methylated with mean methylation of 45±13.8, whereas for control mean methylation was found to be 7.3±3.7 amongst 16 % methylation positive control samples.
|
31653136 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Depletion of COX-2, by celecoxib treatment, resulted in attenuated nuclear translocation of Snail, and, in turn, significantly increased E-cadherin in EOC cell line SKOV3, which was established to be due to the reduced binding of Snail onto E-cadherin promoter.
|
29932878 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
Biomarker
|
disease |
BEFREE |
The CDH1, DLEC1 and SFRP5 methylation panel is a potential prognostic biomarker for advanced EOC.
|
30324802 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, the evaluation of E-cadherin expression in an OC tissue microarray revealed its prognostic value to discriminate between advanced- and early-stage tumors, as well as serous tumors from other histologies.
|
28934230 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Decreased epithelial cadherin (E-cadherin) expression is hypothesized to be related to poor prognosis of ovarian cancer, but the predictive value is still inconsistent.
|
29113377 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
Biomarker
|
disease |
BEFREE |
The prognostic role of epithelial cadherin (E-cadherin) downregulation in ovarian cancer has been assessed for years while the results remain inconclusive.
|
29113366 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No significant association was detected between the CDH1 3'-UTR +54C/T polymorphism and survival of the patients with EOC.
|
27779545 |
2016 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
The findings showed that CDH1 promoter methylation had an increased risk of ovarian cancer in cancer tissues (OR = 8.71, P < 0.001) in comparison with nonmalignant tissues.
|
27067410 |
2016 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
In conclusion, Dysfunction of the cell cycle and/or the cell-cell adhesion molecule plays a role in the pathogenesis of ovarian cancer and that the analysis of the methylation of p15 and E-cadherin genes can provide clinically important evidence on which to base the treatment.
|
23572389 |
2015 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Our results suggest that reduced expression of E-cadherin is associated with promoter methylation of E-cadherin gene, in addition to providing evidence for the aberrant nuclear localization of E-cadherin in EOC.
|
23605324 |
2013 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the expression of epithelial-mesenchymal transition-related genes such as ZEB2 and CDH1 may play important roles in the invasion process of advanced stage serous ovarian cancer.
|
19486012 |
2009 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
E-cadherin protein expression in was lower in C/C genotype carriers than T allele carriers in ovarian cancer tissue (P=0.02).
|
18035404 |
2008 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
This study assessed the immuno-expression of E-cadherin and methylation of CDH1 and correlated them with clinical features in primary epithelial ovarian cancer.
|
16826427 |
2006 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
Biomarker
|
disease |
BEFREE |
Promoter CpG hypermethylation may be an alternative to mutation(s) to inactivate tumour suppressor genes such as MGMT, CDH1, RAR-beta and SYK, and this can also be an early event in the pathogenesis of OCs.
|
14970867 |
2004 |
|
Carcinoma, Ovarian Epithelial
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|