TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs1799724
rs1799724 		0.600 0.680 6 31574705 upstream gene variant C/T snv 8.5E-02
CUI: C4016417
Disease: VASCULAR DEMENTIA, SUSCEPTIBILITY TO
VASCULAR DEMENTIA, SUSCEPTIBILITY TO 		0.700 0
dbSNP: rs1799724
rs1799724 		0.600 0.680 6 31574705 upstream gene variant C/T snv 8.5E-02
CUI: C1856170
Disease: ALZHEIMER DISEASE, SUSCEPTIBILITY TO
ALZHEIMER DISEASE, SUSCEPTIBILITY TO 		0.700 0
dbSNP: rs281865419
rs281865419 		6 31577157 missense variant C/T snv 8.1E-06 7.0E-06
CUI: C4016415
Disease: TNF RECEPTOR BINDING, ALTERED
TNF RECEPTOR BINDING, ALTERED 		0.700 0
dbSNP: rs1799964
rs1799964 		0.608 0.760 6 31574531 upstream gene variant T/C snv 0.19
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		Digestive System Diseases 0.800 1.000 1 2010 2010
dbSNP: rs1800610
rs1800610 		0.807 0.320 6 31576050 intron variant G/A snv 8.4E-02
CUI: C0018213
Disease: Graves Disease
Graves Disease 		Eye Diseases; Immune System Diseases; Endocrine System Diseases 0.700 1.000 1 2011 2011
dbSNP: rs3093662
rs3093662 		0.851 0.200 6 31576412 intron variant A/G snv 7.1E-02
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome 		Infections; Immune System Diseases 0.700 1.000 1 2009 2009
dbSNP: rs3093662
rs3093662 		0.851 0.200 6 31576412 intron variant A/G snv 7.1E-02
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases 0.700 1.000 1 2007 2007
dbSNP: rs3093664
rs3093664 		6 31576865 intron variant A/G snv 6.9E-02 7.7E-02
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement 		0.700 1.000 1 2018 2018
dbSNP: rs3093668
rs3093668 		1.000 6 31578718 downstream gene variant G/C snv 3.5E-02
CUI: C1836231
Disease: HIV-1, RESISTANCE TO
HIV-1, RESISTANCE TO 		0.700 1.000 1 2009 2009
dbSNP: rs3093668
rs3093668 		1.000 6 31578718 downstream gene variant G/C snv 3.5E-02
CUI: C1836232
Disease: ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO 		0.700 1.000 1 2009 2009
dbSNP: rs3093668
rs3093668 		1.000 6 31578718 downstream gene variant G/C snv 3.5E-02
CUI: C1836230
Disease: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO 		0.700 1.000 1 2009 2009
dbSNP: rs3093668
rs3093668 		1.000 6 31578718 downstream gene variant G/C snv 3.5E-02
CUI: C1836233
Disease: AIDS, PROGRESSION TO
AIDS, PROGRESSION TO 		0.700 1.000 1 2009 2009
dbSNP: rs1232013698
rs1232013698 		6 31577208 missense variant G/T snv 4.1E-06
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases 		Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases 0.010 1.000 1 2009 2009
dbSNP: rs1250554906
rs1250554906 		1.000 0.120 6 31576808 missense variant G/A snv 4.1E-06 7.0E-06
CUI: C0393814
Disease: Hereditary liability to pressure palsies
Hereditary liability to pressure palsies 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases 0.010 1.000 1 2014 2014
dbSNP: rs1250915035
rs1250915035 		0.925 6 31576537 missense variant C/T snv 4.0E-06
CUI: C0374997
Disease: Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 		0.010 1.000 1 2017 2017
dbSNP: rs1250915035
rs1250915035 		0.925 6 31576537 missense variant C/T snv 4.0E-06
CUI: C3826128
Disease: Infection in children
Infection in children 		0.010 1.000 1 2017 2017
dbSNP: rs1330189219
rs1330189219 		0.882 0.080 6 31573570 synonymous variant C/T snv 4.0E-06
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		Neoplasms 0.010 1.000 1 2008 2008
dbSNP: rs1330189219
rs1330189219 		0.882 0.080 6 31573570 synonymous variant C/T snv 4.0E-06
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		Neoplasms; Respiratory Tract Diseases 0.010 1.000 1 2008 2008
dbSNP: rs1330189219
rs1330189219 		0.882 0.080 6 31573570 synonymous variant C/T snv 4.0E-06
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		Neoplasms 0.010 1.000 1 2008 2008
dbSNP: rs1330189219
rs1330189219 		0.882 0.080 6 31573570 synonymous variant C/T snv 4.0E-06
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		Neoplasms; Respiratory Tract Diseases 0.010 1.000 1 2008 2008
dbSNP: rs1330189219
rs1330189219 		0.882 0.080 6 31573570 synonymous variant C/T snv 4.0E-06
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		Neoplasms; Respiratory Tract Diseases 0.010 1.000 1 2008 2008
dbSNP: rs1363819544
rs1363819544 		1.000 0.160 6 31577126 synonymous variant A/G snv 7.0E-06
CUI: C0522624
Disease: Subcutaneous panniculitis-like T-cell lymphoma
Subcutaneous panniculitis-like T-cell lymphoma 		Neoplasms; Skin and Connective Tissue Diseases; Immune System Diseases; Hemic and Lymphatic Diseases 0.010 1.000 1 2018 2018
dbSNP: rs1400328611
rs1400328611 		1.000 0.080 6 31575804 frameshift variant AG/- del
CUI: C0281899
Disease: Prolapsed lumbar disc
Prolapsed lumbar disc 		Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases 0.010 1.000 1 2011 2011
dbSNP: rs1411364031
rs1411364031 		0.882 0.040 6 31577502 missense variant T/C snv 7.0E-06
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		Cardiovascular Diseases 0.010 1.000 1 2014 2014
dbSNP: rs1411364031
rs1411364031 		0.882 0.040 6 31577502 missense variant T/C snv 7.0E-06
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		Cardiovascular Diseases 0.010 1.000 1 2014 2014