TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs1799724
rs1799724 		0.600 0.680 6 31574705 upstream gene variant C/T snv 8.5E-02
CUI: C4016417
Disease: VASCULAR DEMENTIA, SUSCEPTIBILITY TO
VASCULAR DEMENTIA, SUSCEPTIBILITY TO 		0.700 0
dbSNP: rs1799724
rs1799724 		0.600 0.680 6 31574705 upstream gene variant C/T snv 8.5E-02
CUI: C1856170
Disease: ALZHEIMER DISEASE, SUSCEPTIBILITY TO
ALZHEIMER DISEASE, SUSCEPTIBILITY TO 		0.700 0
dbSNP: rs281865419
rs281865419 		6 31577157 missense variant C/T snv 8.1E-06 7.0E-06
CUI: C4016415
Disease: TNF RECEPTOR BINDING, ALTERED
TNF RECEPTOR BINDING, ALTERED 		0.700 0
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases 0.020 0.500 2 2003 2005
dbSNP: rs1799724
rs1799724 		0.600 0.680 6 31574705 upstream gene variant C/T snv 8.5E-02
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		Nervous System Diseases; Mental Disorders 0.010 1.000 1 2005 2005
dbSNP: rs1800629
rs1800629 		0.472 0.920 6 31575254 upstream gene variant G/A snv 0.12 0.14
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		Nutritional and Metabolic Diseases; Musculoskeletal Diseases 0.010 1.000 1 2005 2005
dbSNP: rs1800629
rs1800629 		0.472 0.920 6 31575254 upstream gene variant G/A snv 0.12 0.14
CUI: C0521170
Disease: Osteoporotic Fractures
Osteoporotic Fractures 		Wounds and Injuries 0.010 1.000 1 2005 2005
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		Cardiovascular Diseases 0.010 < 0.001 1 2005 2005
dbSNP: rs548532642
rs548532642 		0.882 0.080 6 31577184 missense variant G/A;T snv 1.6E-05
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		Digestive System Diseases 0.010 1.000 1 2006 2006
dbSNP: rs548532642
rs548532642 		0.882 0.080 6 31577184 missense variant G/A;T snv 1.6E-05
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		Digestive System Diseases 0.010 1.000 1 2006 2006
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		Nutritional and Metabolic Diseases; Endocrine System Diseases 0.010 1.000 1 2006 2006
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases 0.010 < 0.001 1 2006 2006
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C1845050
Disease: PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS
PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS 		Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases 0.010 1.000 1 2006 2006
dbSNP: rs1799724
rs1799724 		0.600 0.680 6 31574705 upstream gene variant C/T snv 8.5E-02
CUI: C2747816
Disease: Complicated malaria
Complicated malaria 		Infections 0.010 1.000 1 2007 2007
dbSNP: rs1799724
rs1799724 		0.600 0.680 6 31574705 upstream gene variant C/T snv 8.5E-02
CUI: C0024535
Disease: Malaria, Falciparum
Malaria, Falciparum 		Infections 0.010 1.000 1 2007 2007
dbSNP: rs1799964
rs1799964 		0.608 0.760 6 31574531 upstream gene variant T/C snv 0.19
CUI: C0024535
Disease: Malaria, Falciparum
Malaria, Falciparum 		Infections 0.010 1.000 1 2007 2007
dbSNP: rs1799964
rs1799964 		0.608 0.760 6 31574531 upstream gene variant T/C snv 0.19
CUI: C2747816
Disease: Complicated malaria
Complicated malaria 		Infections 0.010 1.000 1 2007 2007
dbSNP: rs1800630
rs1800630 		0.701 0.480 6 31574699 upstream gene variant C/A snv 0.14
CUI: C2747816
Disease: Complicated malaria
Complicated malaria 		Infections 0.010 1.000 1 2007 2007
dbSNP: rs3093662
rs3093662 		0.851 0.200 6 31576412 intron variant A/G snv 7.1E-02
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases 0.700 1.000 1 2007 2007
dbSNP: rs370893734
rs370893734 		1.000 0.200 6 31577481 missense variant G/A;T snv 2.0E-05; 1.6E-05
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases 0.010 1.000 1 2007 2007
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0004096
Disease: Asthma
Asthma 		Respiratory Tract Diseases; Immune System Diseases 0.010 1.000 1 2007 2007
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0036631
Disease: Seminoma
Seminoma 		Neoplasms 0.010 1.000 1 2007 2007
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C1336708
Disease: Testicular Germ Cell Tumor
Testicular Germ Cell Tumor 		Neoplasms; Male Urogenital Diseases; Endocrine System Diseases 0.010 1.000 1 2007 2007
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C1335059
Disease: testicular nonseminoma
testicular nonseminoma 		0.010 1.000 1 2007 2007
dbSNP: rs361525
rs361525 		0.562 0.760 6 31575324 upstream gene variant G/A snv 4.6E-02
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases 0.020 0.500 2 2006 2008