KL, klotho, 9365

N. diseases: 332; N. variants: 20
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs1207568
rs1207568 		0.925 0.120 13 33016046 upstream gene variant G/A snv 0.17
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		Behavior and Behavior Mechanisms 0.010 1.000 1 2017 2017
dbSNP: rs1207568
rs1207568 		0.925 0.120 13 33016046 upstream gene variant G/A snv 0.17
CUI: C0451641
Disease: Urolithiasis
Urolithiasis 		Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases 0.010 1.000 1 2019 2019
dbSNP: rs1207568
rs1207568 		0.925 0.120 13 33016046 upstream gene variant G/A snv 0.17
CUI: C1270972
Disease: Mild cognitive disorder
Mild cognitive disorder 		Mental Disorders 0.010 1.000 1 2017 2017
dbSNP: rs121908423
rs121908423 		0.882 0.040 13 33017018 missense variant A/G snv 4.8E-06 7.0E-06
CUI: C0263628
Disease: Tumoral calcinosis
Tumoral calcinosis 		Nutritional and Metabolic Diseases 0.010 1.000 1 2007 2007
dbSNP: rs211234
rs211234 		1.000 0.040 13 33020990 intron variant G/A;C snv
CUI: C0033117
Disease: Priapism
Priapism 		Male Urogenital Diseases 0.010 1.000 1 2005 2005
dbSNP: rs211239
rs211239 		1.000 0.040 13 33022051 intron variant A/G;T snv
CUI: C0033117
Disease: Priapism
Priapism 		Male Urogenital Diseases 0.010 1.000 1 2005 2005
dbSNP: rs2283368
rs2283368 		1.000 0.040 13 33019132 intron variant T/C snv 0.15
CUI: C0234985
Disease: Mental deterioration
Mental deterioration 		Mental Disorders 0.010 1.000 1 2016 2016
dbSNP: rs2283368
rs2283368 		1.000 0.040 13 33019132 intron variant T/C snv 0.15
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		Mental Disorders 0.010 1.000 1 2016 2016
dbSNP: rs36217263
rs36217263 		1.000 0.040 13 33015697 upstream gene variant A/- del 0.21
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias 		Nutritional and Metabolic Diseases 0.010 1.000 1 2020 2020
dbSNP: rs36217263
rs36217263 		1.000 0.040 13 33015697 upstream gene variant A/- del 0.21
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		Nutritional and Metabolic Diseases; Endocrine System Diseases 0.010 1.000 1 2020 2020
dbSNP: rs36217263
rs36217263 		1.000 0.040 13 33015697 upstream gene variant A/- del 0.21
CUI: C0011847
Disease: Diabetes
Diabetes 		Endocrine System Diseases 0.010 1.000 1 2020 2020
dbSNP: rs36217263
rs36217263 		1.000 0.040 13 33015697 upstream gene variant A/- del 0.21
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		Cardiovascular Diseases 0.010 1.000 1 2020 2020
dbSNP: rs3752472
rs3752472 		0.882 0.120 13 33055256 missense variant C/T snv 2.9E-02 1.5E-02
CUI: C0392525
Disease: Nephrolithiasis
Nephrolithiasis 		Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases 0.010 1.000 1 2013 2013
dbSNP: rs3752472
rs3752472 		0.882 0.120 13 33055256 missense variant C/T snv 2.9E-02 1.5E-02
CUI: C0022650
Disease: Kidney Calculi
Kidney Calculi 		Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases 0.010 1.000 1 2013 2013
dbSNP: rs3752472
rs3752472 		0.882 0.120 13 33055256 missense variant C/T snv 2.9E-02 1.5E-02
CUI: C1833683
Disease: NEPHROLITHIASIS, CALCIUM OXALATE
NEPHROLITHIASIS, CALCIUM OXALATE 		Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases 0.010 1.000 1 2013 2013
dbSNP: rs495392
rs495392 		1.000 0.040 13 33018055 intron variant C/A snv 0.24
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases 		Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases 0.010 1.000 1 2019 2019
dbSNP: rs495392
rs495392 		1.000 0.040 13 33018055 intron variant C/A snv 0.24
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		Cardiovascular Diseases 0.010 1.000 1 2019 2019
dbSNP: rs562020
rs562020 		1.000 0.040 13 33017932 intron variant A/G snv 0.69
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		Cardiovascular Diseases 0.010 1.000 1 2019 2019
dbSNP: rs564481
rs564481 		0.882 0.080 13 33060846 missense variant C/A;T snv 1.2E-05; 0.38
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis 		Musculoskeletal Diseases 0.010 1.000 1 2019 2019
dbSNP: rs564481
rs564481 		0.882 0.080 13 33060846 missense variant C/A;T snv 1.2E-05; 0.38
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		Cardiovascular Diseases 0.010 1.000 1 2018 2018
dbSNP: rs564481
rs564481 		0.882 0.080 13 33060846 missense variant C/A;T snv 1.2E-05; 0.38
CUI: C0238694
Disease: Peripheral arthritis
Peripheral arthritis 		Musculoskeletal Diseases 0.010 1.000 1 2019 2019
dbSNP: rs564481
rs564481 		0.882 0.080 13 33060846 missense variant C/A;T snv 1.2E-05; 0.38
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		Cardiovascular Diseases 0.010 1.000 1 2018 2018
dbSNP: rs567170
rs567170 		1.000 0.040 13 33043649 intron variant C/G snv 0.32
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		Cardiovascular Diseases 0.010 1.000 1 2019 2019
dbSNP: rs650439
rs650439 		1.000 0.080 13 33061802 intron variant T/A snv 0.82 0.81
CUI: C0577631
Disease: Carotid Atherosclerosis
Carotid Atherosclerosis 		Nervous System Diseases; Cardiovascular Diseases 0.010 1.000 1 2010 2010
dbSNP: rs650439
rs650439 		1.000 0.080 13 33061802 intron variant T/A snv 0.82 0.81
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		Nervous System Diseases; Cardiovascular Diseases 0.010 1.000 1 2018 2018