NAT2, N-acetyltransferase 2, 10

N. diseases: 311; N. variants: 10
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1961456
rs1961456
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C1445957
Disease:
Serum total cholesterol measurement
A 0.700 GeneticVariation GWASCAT Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 28334899 2017
dbSNP: rs1961456
rs1961456
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0202236
Disease:
Triglycerides measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.030 GeneticVariation BEFREE We investigated whether functional GSTP1 (p.Ile105Val-rs1695), NAT2 (590G>A-rs1799930) SNPs and GSTM1 and GSTT1 deletion polymorphisms could modulate the effect of the Mediterranean diet (MD) on BC risk, in Greek-Cypriot women. 26572891 2017
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0678222
Disease:
Breast Carcinoma
0.030 GeneticVariation BEFREE We investigated whether functional GSTP1 (p.Ile105Val-rs1695), NAT2 (590G>A-rs1799930) SNPs and GSTM1 and GSTT1 deletion polymorphisms could modulate the effect of the Mediterranean diet (MD) on BC risk, in Greek-Cypriot women. 26572891 2017
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.030 GeneticVariation BEFREE Our results confirm the hypothesis that NAT2 gene polymorphisms (rs1041983 C/T, rs1801280 T/C, and rs1799930 G/A) in association with long-period active smoking could be the possible individual risk-predicting factors for breast cancer development in the population of Slovak women. 26700672 2016
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0678222
Disease:
Breast Carcinoma
0.030 GeneticVariation BEFREE When comparing a group of women smoking more than 5 cigarettes a day with the patients smoking fewer than 5 cigarettes a day, we found out that if women were the carriers of aberrant AA genotype for rs1799930, the first group of women had higher risk of breast carcinoma than the second group. 26700672 2016
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C1306459
Disease:
Primary malignant neoplasm
0.030 GeneticVariation BEFREE We found that the NAT2 rs1799930 may be a risk factor, while the NAT2 rs1799931 polymorphism is associated with a decreased risk of cancer and is likely a protective factor against cancer development. 25081676 2014
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0006826
Disease:
Malignant Neoplasms
0.030 GeneticVariation BEFREE The NAT2 rs1799930 (G590A) may change drug-induced toxicity and affect cancer susceptibility. 25005845 2014
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C1306459
Disease:
Primary malignant neoplasm
0.030 GeneticVariation BEFREE The NAT2 rs1799930 (G590A) may change drug-induced toxicity and affect cancer susceptibility. 25005845 2014
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0006826
Disease:
Malignant Neoplasms
0.030 GeneticVariation BEFREE We found that the NAT2 rs1799930 may be a risk factor, while the NAT2 rs1799931 polymorphism is associated with a decreased risk of cancer and is likely a protective factor against cancer development. 25081676 2014
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0678222
Disease:
Breast Carcinoma
0.030 GeneticVariation BEFREE A stratified analysis by menopausal status indicated the association between the NAT2 SNP (rs1799930) and breast cancer was mainly evident in premenopausal women (OR 2.70, 95% CI 1.20-6.07), while the MTRR SNP (rs162049) was significant in postmenopausal women (OR 1.61, 95% CI 1.07-2.44). 20180013 2010
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.030 GeneticVariation BEFREE A stratified analysis by menopausal status indicated the association between the NAT2 SNP (rs1799930) and breast cancer was mainly evident in premenopausal women (OR 2.70, 95% CI 1.20-6.07), while the MTRR SNP (rs162049) was significant in postmenopausal women (OR 1.61, 95% CI 1.07-2.44). 20180013 2010
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0006826
Disease:
Malignant Neoplasms
0.030 GeneticVariation BEFREE The extraction method was combined with newly designed PCR-based assays for cancer susceptibility marker genes such as CYP1A1 (exon 7), CYP2E1 (Dra1, Rsa1), GSTM1 and NAT2 [NAT2*5A (C481T), NAT2*6A (G590A), NAT2*7A (G857A)]. 9214613 1997
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C1306459
Disease:
Primary malignant neoplasm
0.030 GeneticVariation BEFREE The extraction method was combined with newly designed PCR-based assays for cancer susceptibility marker genes such as CYP1A1 (exon 7), CYP2E1 (Dra1, Rsa1), GSTM1 and NAT2 [NAT2*5A (C481T), NAT2*6A (G590A), NAT2*7A (G857A)]. 9214613 1997
dbSNP: rs1208
rs1208
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0010068
Disease:
Coronary heart disease
0.020 GeneticVariation BEFREE We conducted a hospital-based case-control study to investigate the association of NAT2 gene polymorphisms (rs1799930 G/A, rs1208 A/G, and rs1799931 G/A) and the combinations of PAHs exposure and genetic variants with the risk of CHDs. 31254350 2019
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0021364
Disease:
Male infertility
0.020 GeneticVariation BEFREE This pilot study is the first (as far as we know) to reveal that polymorphisms of NAT2 (rs1799929, rs1799930) and GSTP1 (rs1138272, rs1695) are some novel genetic markers for susceptibility to idiopathic male infertility. 29505746 2018
dbSNP: rs1208
rs1208
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0010068
Disease:
Coronary heart disease
0.020 GeneticVariation BEFREE The rs1208 "A" allele was nominally associated with IR-related traits, including increased fasting glucose, hemoglobin A1C, total and LDL cholesterol, triglycerides, and coronary artery disease. 25798622 2015
dbSNP: rs1799930
rs1799930
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0021364
Disease:
Male infertility
0.020 GeneticVariation BEFREE This pilot study found, as far as is known for the first time, that the polymorphism 590G>A of NAT2 is a novel genetic marker for susceptibility to idiopathic male infertility, but the risk is potentiated by exposure to various environmental oxidants. 24928356 2014
dbSNP: rs1799931
rs1799931
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0006826
Disease:
Malignant Neoplasms
0.020 GeneticVariation BEFREE In contrast, a significant association was observed between the NAT2 rs1799931 G>A polymorphism and decreased cancer susceptibility in overall meta-analysis (AA vs. GG: OR=0.55, 95% CI=0.33-0.93; GA vs. GG: OR=1.00, 95% CI=0.88-1.14; dominant model: OR=0.97, 95% CI=0.86-1.10; recessive model: OR=0.56, 95% CI=0.34-0.94) and the Asian group (AA vs. GG: OR=0.50, 95% CI=0.26-0.94; recessive model, OR=0.50, 95% CI=0.27-0.94). 25081676 2014
dbSNP: rs1799931
rs1799931
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C1306459
Disease:
Primary malignant neoplasm
0.020 GeneticVariation BEFREE In contrast, a significant association was observed between the NAT2 rs1799931 G>A polymorphism and decreased cancer susceptibility in overall meta-analysis (AA vs. GG: OR=0.55, 95% CI=0.33-0.93; GA vs. GG: OR=1.00, 95% CI=0.88-1.14; dominant model: OR=0.97, 95% CI=0.86-1.10; recessive model: OR=0.56, 95% CI=0.34-0.94) and the Asian group (AA vs. GG: OR=0.50, 95% CI=0.26-0.94; recessive model, OR=0.50, 95% CI=0.27-0.94). 25081676 2014
dbSNP: rs1799931
rs1799931
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0024623
Disease:
Malignant neoplasm of stomach
0.020 GeneticVariation BEFREE Statistical analysis results showed significant association of SNPs rs9344, rs1799931, and rs1800629 with the risk of gastric cancer. 23072573 2013
dbSNP: rs1799931
rs1799931
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.020 GeneticVariation BEFREE We conducted a family-based case-control study to investigate the association between polymorphisms in carcinogen metabolism genes (CYP1A2 -154A>C, CYP1B1 Leu432Val, CYP2E1 -1054C>T, GSTP1 Ile105Val, PTGS2 5UTR -765, EPHX1 Tyr113His, NAT2 Ile114Thr, NAT2 Arg197Gln and NAT2 Gly286Glu) and CRC risk. 21618522 2012
dbSNP: rs1801280
rs1801280
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.020 GeneticVariation BEFREE We conducted a family-based case-control study to investigate the association between polymorphisms in carcinogen metabolism genes (CYP1A2 -154A>C, CYP1B1 Leu432Val, CYP2E1 -1054C>T, GSTP1 Ile105Val, PTGS2 5UTR -765, EPHX1 Tyr113His, NAT2 Ile114Thr, NAT2 Arg197Gln and NAT2 Gly286Glu) and CRC risk. 21618522 2012
dbSNP: rs1799931
rs1799931
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.020 GeneticVariation BEFREE Correlations between NAT2*5C(T341C), NAT2*5A(C481T), NAT2*6B(G590A), NAT2*7B(G857A) polymorphisms and survival of patients with different Dukes-MAC stages of CRC were analyzed. 21188325 2010
dbSNP: rs1801280
rs1801280
Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.020 GeneticVariation BEFREE Correlations between NAT2*5C(T341C), NAT2*5A(C481T), NAT2*6B(G590A), NAT2*7B(G857A) polymorphisms and survival of patients with different Dukes-MAC stages of CRC were analyzed. 21188325 2010