|
rs17041868
|
BCL2L11;MIR4435-2HG
|
Waist-Hip Ratio
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
rs3761706
|
BCL2L11;MIR4435-2HG
|
Waist-Hip Ratio
|
|
0.700 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs56952027
|
BCL2L11;ACOXL;MIR4435-2HG
|
Body Height
|
|
0.700 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs72836346
|
BCL2L11;ACOXL;MIR4435-2HG
|
Eosinophil count procedure
|
|
0.700 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs11691517
|
BCL2L11;MIR4435-2HG
|
Prostate carcinoma
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
|
29892016 |
2018 |
|
rs17041868
|
BCL2L11;MIR4435-2HG
|
Waist-Hip Ratio
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.
|
30575882 |
2018 |
|
rs56366063
|
BCL2L11;MIR4435-2HG
|
Prostate carcinoma
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
|
29892016 |
2018 |
|
rs71801447
|
BCL2L11;MIR4435-2HG
|
Breast Carcinoma
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs17484848
|
BCL2L11;MIR4435-2HG
|
Blood basophil count (lab test)
|
C |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
rs17484848
|
BCL2L11;MIR4435-2HG
|
Eosinophil count procedure
|
C |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
rs6734942
|
BCL2L11;MIR4435-2HG
|
Monocyte count result
|
T |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
rs6734942
|
BCL2L11;MIR4435-2HG
|
Monocyte count procedure
|
T |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
rs68021656
|
BCL2L11;MIR4435-2HG
|
Reticulocyte count (procedure)
|
GT |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
rs9308731
|
BCL2L11;MIR4435-2HG
|
Small Lymphocytic Lymphoma
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
|
26956414 |
2016 |
|
rs9308731
|
BCL2L11;MIR4435-2HG
|
Chronic Lymphocytic Leukemia
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
|
26956414 |
2016 |
|
rs17041869
|
BCL2L11;MIR4435-2HG
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3).
|
27432226 |
2016 |
|
rs1296169581
|
BCL2L11;MIR4435-2HG
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
Five of the 7 (71%) responders were BRAF(WT), of which 1 carried c-KIT(L576P) and another N-RAS(Q61R) mutation, while only 2 (29%) of the responding tumors were BRAF(V600E/K).
|
22351689 |
2012 |
|
rs3789068
|
BCL2L11;MIR4435-2HG
|
Lymphoma, Non-Hodgkin
|
|
0.010 |
GeneticVariation |
BEFREE |
A meta-analysis was performed on data from 5633 B-cell NHL cases and 7034 controls from 8 InterLymph studies. rs3789068 in the proapoptotic BCL2L11 gene was associated with an increased risk for B-cell NHL (odds ratio = 1.21, P random = 2.21 × 10(-11)), with similar risk estimates for common B-cell subtypes.
|
23047821 |
2012 |
|
rs374980122
|
BCL2L11;MIR4435-2HG
|
melanoma
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, this report indicates that N-RAS(Q61K) and B-RAF(V600E) contribute to melanoma's resistance to apoptosis in part by downregulating Bim expression, suggesting that Bim is a possible treatment target for overriding melanoma's inherent defenses against cell death.
|
18668139 |
2009 |
|
rs3789068
|
BCL2L11;MIR4435-2HG
|
Lymphoma, Follicular
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants in BCL2L11 were strongly related to follicular lymphoma only, particularly rs3789068 (OR(AG), 1.41; 95% CI, 1.10-1.81; OR(GG), 1.65; 95% CI, 1.25-2.19; P(trend) = 0.0004).
|
19336552 |
2009 |
|
rs770692189
|
BCL2L11;MIR4435-2HG
|
Autoimmune Lymphoproliferative Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
We show here that the salient features of ALPS as well as a predisposition to hematological malignancies can be caused by a heterozygous germline Gly13Asp activating mutation of the NRAS oncogene that does not impair CD95-mediated apoptosis.
|
17517660 |
2007 |
|
rs770692189
|
BCL2L11;MIR4435-2HG
|
Hematologic Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
We show here that the salient features of ALPS as well as a predisposition to hematological malignancies can be caused by a heterozygous germline Gly13Asp activating mutation of the NRAS oncogene that does not impair CD95-mediated apoptosis.
|
17517660 |
2007 |