rs3184504
|
ATXN2;SH2B3
|
Coronary heart disease
|
T |
0.820 |
GeneticVariation |
GWASCAT |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
rs3184504
|
ATXN2;SH2B3
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.820 |
GeneticVariation |
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
rs3184504
|
ATXN2;SH2B3
|
Coronary heart disease
|
|
0.820 |
GeneticVariation |
BEFREE |
The R262W polymorphism is associated with risk of CHD or MI in Europeans, but not in Asians.
|
30508957 |
2018 |
rs3184504
|
ATXN2;SH2B3
|
Diabetes Mellitus, Insulin-Dependent
|
T |
0.820 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
rs3184504
|
ATXN2;SH2B3
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.820 |
GeneticVariation |
BEFREE |
The SH2B3 784T>C variant could contribute to the pathogenesis of T1D through impaired immune response that promotes activation and expansion of self-reactive lymphocytes in susceptible individuals.
|
20546165 |
2011 |
rs3184504
|
ATXN2;SH2B3
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.820 |
GeneticVariation |
GWASDB |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
rs3184504
|
ATXN2;SH2B3
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.820 |
GeneticVariation |
BEFREE |
After adjusting for country, sex, family history, and all other genetic loci, significantly greater co-occurrence was observed in children with a T1D family history (HR: 2.80), HLA-DR3/4 (HR: 1.94) and single-nucleotide polymorphism rs3184504 at SH2B3 (HR: 1.53).
|
29018046 |
2017 |
rs3184504
|
ATXN2;SH2B3
|
Coronary heart disease
|
|
0.820 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
rs3184504
|
ATXN2;SH2B3
|
Diabetes Mellitus, Insulin-Dependent
|
A |
0.820 |
GeneticVariation |
GWASCAT |
Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort.
|
29310926 |
2018 |
rs3184504
|
ATXN2;SH2B3
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.820 |
GeneticVariation |
GWASCAT |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
rs3184504
|
ATXN2;SH2B3
|
Coronary heart disease
|
|
0.820 |
GeneticVariation |
BEFREE |
In conclusion, our results supported a significant association between rs3184504 of SH2B3 gene and the risk of CHD in Europeans and South Asians, although we were unable to observe association between the four variants and the risk of CHD in Han Chinese.
|
23328882 |
2013 |
rs3184504
|
ATXN2;SH2B3
|
Celiac Disease
|
|
0.810 |
GeneticVariation |
GWASDB |
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.
|
22057235 |
2011 |
rs3184504
|
ATXN2;SH2B3
|
Celiac Disease
|
C |
0.810 |
GeneticVariation |
GWASCAT |
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.
|
22057235 |
2011 |
rs3184504
|
ATXN2;SH2B3
|
Coronary Artery Disease
|
|
0.810 |
GeneticVariation |
BEFREE |
Role of SH2B3 R262W gene polymorphism and risk of coronary heart disease: A PRISMA-compliant meta-analysis.
|
30508957 |
2018 |
rs3184504
|
ATXN2;SH2B3
|
Coronary Artery Disease
|
|
0.810 |
GeneticVariation |
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
rs3184504
|
ATXN2;SH2B3
|
Coronary Artery Disease
|
T |
0.810 |
GeneticVariation |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
rs3184504
|
ATXN2;SH2B3
|
Coronary Artery Disease
|
T |
0.810 |
GeneticVariation |
GWASDB |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
rs3184504
|
ATXN2;SH2B3
|
Celiac Disease
|
|
0.810 |
GeneticVariation |
BEFREE |
However, the minor allele A of rs3184504 (A vs G, OR = 1.18, 95%CI = 1.12-1.24, P < 0.001) in SH2B3 significantly increased CD susceptibility.
|
26535636 |
2015 |
rs3184504
|
ATXN2;SH2B3
|
Coronary Artery Disease
|
T |
0.810 |
GeneticVariation |
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |
rs3184504
|
ATXN2;SH2B3
|
Beta-2-microglobulin measurement
|
C |
0.800 |
GeneticVariation |
GWASDB |
The other locus of B2M was on chromosome 12 (rs3184504 at SH2B3, beta = 0.02, p value = 3.1 × 10(-8)), which was previously implicated as an eGFR locus.
|
23417110 |
2013 |
rs3184504
|
ATXN2;SH2B3
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation |
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
rs3184504
|
ATXN2;SH2B3
|
Red Blood Cell Count measurement
|
|
0.800 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
rs3184504
|
ATXN2;SH2B3
|
Platelet Count measurement
|
C |
0.800 |
GeneticVariation |
GWASCAT |
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
|
24026423 |
2014 |
rs3184504
|
ATXN2;SH2B3
|
Autoantibody measurement
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort.
|
29310926 |
2018 |
rs3184504
|
ATXN2;SH2B3
|
Platelet Count measurement
|
C |
0.800 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |