ADD3-AS1, ADD3 antisense RNA 1, 100505933

N. diseases: 4; N. variants: 4
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs17095355
rs17095355
Entrez Id: 100505933
Gene Symbol: ADD3-AS1
ADD3-AS1
CUI: C0005411
Disease:
Biliary Atresia
0.840 GeneticVariation BEFREE The risk allele frequencies of rs2501577, rs11194981, and rs17095355 in the BA group were significantly higher than in the controls. 29508064 2018
dbSNP: rs17095355
rs17095355
Entrez Id: 100505933
Gene Symbol: ADD3-AS1
ADD3-AS1
CUI: C0005411
Disease:
Biliary Atresia
0.840 GeneticVariation BEFREE Two SNPs in <i>ADD3</i> were replicated as associated with BA (1.60E-04 ≤ <i>P</i>≤1.70E-04, 1.33 ≤ odds ratio (OR) ≤ 1.58 for rs17095355, 2.10E-04 ≤ <i>P</i>≤5.30E-04, 1.26 ≤ OR ≤ 1.57 for rs2501577). 29685956 2018
dbSNP: rs17095355
rs17095355
Entrez Id: 100505933
Gene Symbol: ADD3-AS1
ADD3-AS1
CUI: C0005411
Disease:
Biliary Atresia
0.840 GeneticVariation BEFREE This meta-analysis confirms the association of rs17095355 polymorphism and BA development, especially in Asians. 27557278 2017
dbSNP: rs17095355
rs17095355
Entrez Id: 100505933
Gene Symbol: ADD3-AS1
ADD3-AS1
CUI: C0005411
Disease:
Biliary Atresia
0.840 GeneticVariation BEFREE This study suggests that the ADD3 gene plays an important role in BA pathogenesis and reveals a significant association between two SNPs, rs17095355 and rs10509906, and BA. 25285724 2014
dbSNP: rs17095355
rs17095355
Entrez Id: 100505933
Gene Symbol: ADD3-AS1
ADD3-AS1
CUI: C0005411
Disease:
Biliary Atresia
T 0.840 GeneticVariation GWASDB Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. 20460270 2010
dbSNP: rs17095355
rs17095355
Entrez Id: 100505933
Gene Symbol: ADD3-AS1
ADD3-AS1
CUI: C0005411
Disease:
Biliary Atresia
T 0.840 GeneticVariation GWASCAT Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. 20460270 2010
dbSNP: rs12572168
rs12572168
Entrez Id: 120;100505933
Gene Symbol: ADD3;ADD3-AS1
ADD3;ADD3-AS1
CUI: C0200638
Disease:
Eosinophil count procedure
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs72828224
rs72828224
Entrez Id: 100505933
Gene Symbol: ADD3-AS1
ADD3-AS1
CUI: C0596887
Disease:
mathematical ability
A 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs17095355
rs17095355
Entrez Id: 100505933
Gene Symbol: ADD3-AS1
ADD3-AS1
CUI: C4520983
Disease:
Congenital atresia of extrahepatic bile duct
0.040 GeneticVariation BEFREE The risk allele frequencies of rs2501577, rs11194981, and rs17095355 in the BA group were significantly higher than in the controls. 29508064 2018
dbSNP: rs17095355
rs17095355
Entrez Id: 100505933
Gene Symbol: ADD3-AS1
ADD3-AS1
CUI: C4520983
Disease:
Congenital atresia of extrahepatic bile duct
0.040 GeneticVariation BEFREE Two SNPs in <i>ADD3</i> were replicated as associated with BA (1.60E-04 ≤ <i>P</i>≤1.70E-04, 1.33 ≤ odds ratio (OR) ≤ 1.58 for rs17095355, 2.10E-04 ≤ <i>P</i>≤5.30E-04, 1.26 ≤ OR ≤ 1.57 for rs2501577). 29685956 2018
dbSNP: rs17095355
rs17095355
Entrez Id: 100505933
Gene Symbol: ADD3-AS1
ADD3-AS1
CUI: C4520983
Disease:
Congenital atresia of extrahepatic bile duct
0.040 GeneticVariation BEFREE This meta-analysis confirms the association of rs17095355 polymorphism and BA development, especially in Asians. 27557278 2017
dbSNP: rs17095355
rs17095355
Entrez Id: 100505933
Gene Symbol: ADD3-AS1
ADD3-AS1
CUI: C4520983
Disease:
Congenital atresia of extrahepatic bile duct
0.040 GeneticVariation BEFREE This study suggests that the ADD3 gene plays an important role in BA pathogenesis and reveals a significant association between two SNPs, rs17095355 and rs10509906, and BA. 25285724 2014
dbSNP: rs10509906
rs10509906
Entrez Id: 120;100505933
Gene Symbol: ADD3;ADD3-AS1
ADD3;ADD3-AS1
CUI: C0005411
Disease:
Biliary Atresia
0.020 GeneticVariation BEFREE Though we failed to replicate the individual association of rs10509906 to disease, the intragenic epistatic effect between rs10509906 and rs2501577 was suggested as exhibiting susceptibility to BA, further cross-validated by multifactor dimensionality reduction (MDR) (<i>P</i>=0.068, OR = 1.37), which may explain extra hidden heritability of <i>ADD3</i> to BA. 29685956 2018
dbSNP: rs10509906
rs10509906
Entrez Id: 120;100505933
Gene Symbol: ADD3;ADD3-AS1
ADD3;ADD3-AS1
CUI: C4520983
Disease:
Congenital atresia of extrahepatic bile duct
0.020 GeneticVariation BEFREE Though we failed to replicate the individual association of rs10509906 to disease, the intragenic epistatic effect between rs10509906 and rs2501577 was suggested as exhibiting susceptibility to BA, further cross-validated by multifactor dimensionality reduction (MDR) (<i>P</i>=0.068, OR = 1.37), which may explain extra hidden heritability of <i>ADD3</i> to BA. 29685956 2018
dbSNP: rs10509906
rs10509906
Entrez Id: 120;100505933
Gene Symbol: ADD3;ADD3-AS1
ADD3;ADD3-AS1
CUI: C0005411
Disease:
Biliary Atresia
0.020 GeneticVariation BEFREE This study suggests that the ADD3 gene plays an important role in BA pathogenesis and reveals a significant association between two SNPs, rs17095355 and rs10509906, and BA. 25285724 2014
dbSNP: rs10509906
rs10509906
Entrez Id: 120;100505933
Gene Symbol: ADD3;ADD3-AS1
ADD3;ADD3-AS1
CUI: C4520983
Disease:
Congenital atresia of extrahepatic bile duct
0.020 GeneticVariation BEFREE This study suggests that the ADD3 gene plays an important role in BA pathogenesis and reveals a significant association between two SNPs, rs17095355 and rs10509906, and BA. 25285724 2014