TNK2, tyrosine kinase non receptor 2, 10188

N. diseases: 59; N. variants: 6
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs114951929
rs114951929
Entrez Id: 10188
Gene Symbol: TNK2
TNK2
CUI: C1519383
Disease:
Smoking Behaviors 		0.700 GeneticVariation GWASCAT Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 26053186 2015
dbSNP: rs114951929
rs114951929
Entrez Id: 10188
Gene Symbol: TNK2
TNK2
CUI: C0037369
Disease:
Smoking 		0.700 GeneticVariation GWASCAT Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. 26053186 2015
dbSNP: rs112384084
rs112384084
Entrez Id: 10188
Gene Symbol: TNK2
TNK2
CUI: C0030567
Disease:
Parkinson Disease 		T 0.700 GeneticVariation CLINVAR
dbSNP: rs113498671
rs113498671
Entrez Id: 10188
Gene Symbol: TNK2
TNK2
CUI: C1335167
Disease:
Ovarian Mucinous Adenocarcinoma 		0.700 GeneticVariation UNIPROT
dbSNP: rs970946035
rs970946035
Entrez Id: 10188
Gene Symbol: TNK2
TNK2
CUI: C0346163
Disease:
Endometrioid carcinoma ovary 		0.700 GeneticVariation UNIPROT
dbSNP: rs201768983
rs201768983
Entrez Id: 10188
Gene Symbol: TNK2
TNK2
CUI: C0476089
Disease:
Endometrial Carcinoma 		0.010 GeneticVariation BEFREE The TNK2(P761Rfs*72) frameshift mutation was recurrent in EC, and the DDR1(R570Q) missense mutation was recurrent across tumor types. 25427824 2014
dbSNP: rs201768983
rs201768983
Entrez Id: 10188
Gene Symbol: TNK2
TNK2
CUI: C0007103
Disease:
Malignant neoplasm of endometrium 		0.010 GeneticVariation BEFREE The TNK2(P761Rfs*72) frameshift mutation was recurrent in EC, and the DDR1(R570Q) missense mutation was recurrent across tumor types. 25427824 2014
dbSNP: rs2278034
rs2278034
Entrez Id: 10188
Gene Symbol: TNK2
TNK2
CUI: C0019196
Disease:
Hepatitis C 		0.010 GeneticVariation BEFREE SNP rs2278034 in ACK1 is associated with IFN therapy outcome in patients with HCV. 21129804 2011
dbSNP: rs970946035
rs970946035
Entrez Id: 10188
Gene Symbol: TNK2
TNK2
CUI: C1306459
Disease:
Primary malignant neoplasm 		0.010 GeneticVariation BEFREE Thus, the cancer-associated mutation E346K appears to destabilize an autoinhibited conformation of Ack1, leading to constitutively high Ack1 activity. 20110370 2010
dbSNP: rs970946035
rs970946035
Entrez Id: 10188
Gene Symbol: TNK2
TNK2
CUI: C0006826
Disease:
Malignant Neoplasms 		0.010 GeneticVariation BEFREE Thus, the cancer-associated mutation E346K appears to destabilize an autoinhibited conformation of Ack1, leading to constitutively high Ack1 activity. 20110370 2010