|
rs10883365
|
LINC01475
|
Crohn Disease
|
|
0.830 |
GeneticVariation |
BEFREE |
A significantly increased CD or UC risk was observed in persons carrying a G allele at rs10883365 polymorphism (A/G) compared with those with a A allele.
|
24473197 |
2014 |
|
rs10883365
|
LINC01475
|
Crohn Disease
|
|
0.830 |
GeneticVariation |
BEFREE |
We confirmed the association of SNP rs10883365 located in the 5' flanking region of NKX2-3 with Japanese UC and colonic CD and determined the risk haplotype (haplotype B) for UC.
|
21514341 |
2011 |
|
rs10883365
|
LINC01475
|
Crohn Disease
|
|
0.830 |
GeneticVariation |
BEFREE |
NKX2-3 rs10883365 variant allele was associated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79).
|
21049557 |
2010 |
|
rs11190140
|
NKX2-3;LINC01475
|
Crohn Disease
|
|
0.810 |
GeneticVariation |
BEFREE |
For rs11190140 polymorphism (C/T) and CD risk, the risk estimate for the allele contrast was OR = 1.201 (1.136-1.269).
|
24473197 |
2014 |
|
rs10883365
|
LINC01475
|
Ulcerative Colitis
|
|
0.030 |
GeneticVariation |
BEFREE |
NKX2-3 rs10883365 variant allele was associated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79).
|
21049557 |
2010 |
|
rs10883365
|
LINC01475
|
Ulcerative Colitis
|
|
0.030 |
GeneticVariation |
BEFREE |
We confirmed the association of SNP rs10883365 located in the 5' flanking region of NKX2-3 with Japanese UC and colonic CD and determined the risk haplotype (haplotype B) for UC.
|
21514341 |
2011 |
|
rs10883365
|
LINC01475
|
Ulcerative Colitis
|
|
0.030 |
GeneticVariation |
BEFREE |
This meta-analysis provided a robust result that persons with a G or T allele may have a moderately increased risk of CD, and suggested that rs10883365 polymorphism was also a candidate gene polymorphism for UC susceptibility.
|
24473197 |
2014 |
|
rs10883365
|
LINC01475
|
Celiac Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
We aimed to study the implication of five polymorphisms in these genes in CD susceptibility: rs10883365 and rs888208 in the NKX2-3 gene, rs2241880 in ATG16L1, and rs10065172 and rs4958847 in IRGM.
|
19683022 |
2009 |
|
rs11190140
|
NKX2-3;LINC01475
|
Inflammatory Bowel Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
We speculate that the rs11190140 may regulate NKX2-3 expression and have a role in IBD pathogenesis.
|
21803625 |
2012 |
|
rs11190140
|
NKX2-3;LINC01475
|
Irritable Bowel Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFAT.
|
21803625 |
2012 |
|
rs11596008
|
LINC01475
|
Ulcerative Colitis
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 344 patients with Crohn's disease (CD), 253 patients with ulcerative colitis (UC), and 243 healthy controls (HCs) were genotyped for 3 tag-single nucleotide polymorphisms (SNPs; rs10883365, rs888208, and rs11596008) around NKX2.3.
|
21514341 |
2011 |
|
rs11596008
|
LINC01475
|
Crohn Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 344 patients with Crohn's disease (CD), 253 patients with ulcerative colitis (UC), and 243 healthy controls (HCs) were genotyped for 3 tag-single nucleotide polymorphisms (SNPs; rs10883365, rs888208, and rs11596008) around NKX2.3.
|
21514341 |
2011 |
|
rs10883365
|
LINC01475
|
Crohn Disease
|
|
0.830 |
GeneticVariation |
GWASCAT |
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.
|
17554261 |
2007 |
|
rs10883365
|
LINC01475
|
Crohn Disease
|
G |
0.830 |
GeneticVariation |
GWASCAT |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
rs11190140
|
NKX2-3;LINC01475
|
Crohn Disease
|
T |
0.810 |
GeneticVariation |
GWASCAT |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
rs11190140
|
NKX2-3;LINC01475
|
Ulcerative Colitis
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
|
20228799 |
2010 |
|
rs11190141
|
NKX2-3;LINC01475
|
Crohn Disease
|
C |
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
|
22412388 |
2012 |
|
rs12412391
|
LINC01475
|
Colorectal Carcinoma
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
|
26965516 |
2016 |
|
rs12412391
|
LINC01475
|
Colorectal Carcinoma
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
rs6584283
|
LINC01475
|
Ulcerative Colitis
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
|
21297633 |
2011 |
|
rs6584283
|
LINC01475
|
Ulcerative Colitis
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
|
19915572 |
2009 |
|
rs11190141
|
NKX2-3;LINC01475
|
Monocyte count procedure
|
T |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
rs11190141
|
NKX2-3;LINC01475
|
Monocyte count result
|
T |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
rs12412391
|
LINC01475
|
Colorectal Neoplasms
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
|
26965516 |
2016 |
|
rs12412391
|
LINC01475
|
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |