CDKN1A, cyclin dependent kinase inhibitor 1A, 1026

N. diseases: 490; N. variants: 17
Disease: Squamous cell carcinoma of esophagus ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2395655
rs2395655
Entrez Id: 1026;108783646
Gene Symbol: CDKN1A;DINOL
CDKN1A;DINOL
CUI: C0279626
Disease:
Squamous cell carcinoma of esophagus 		0.030 GeneticVariation BEFREE Subsequent specific RNA interference-mediated depletion or ectopic expression of LEDGF/p75 caused obviously down- or up-regulated expression of p21 mRNA in ESCC cells harboring rs2395655 GG genotype but not cells with rs2395655 AA genotype. 30854807 2019
dbSNP: rs2395655
rs2395655
Entrez Id: 1026;108783646
Gene Symbol: CDKN1A;DINOL
CDKN1A;DINOL
CUI: C0279626
Disease:
Squamous cell carcinoma of esophagus 		0.030 GeneticVariation BEFREE The rs3829963 C and rs2395655 G alleles, combined with cigarette smo</span>king, could further increase the risk for E</span>SCC (OR = 2.657 and OR = 2.828, respectively). 26932598 2016
dbSNP: rs2395655
rs2395655
Entrez Id: 1026;108783646
Gene Symbol: CDKN1A;DINOL
CDKN1A;DINOL
CUI: C0279626
Disease:
Squamous cell carcinoma of esophagus 		0.030 GeneticVariation BEFREE In the multiple genetic model, we found that the rs2395655 in CDKN1A is related with the risk of ESCC, and that the G allele increases the susceptibility to ESCC (OR: 1.364; 95% CI: 1.104-1.685). 24474449 2014