|
rs3217992
|
CDKN2B;CDKN2B-AS1
|
Calcification of coronary artery
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.
|
22144573 |
2011 |
|
rs1423790481
|
CDKN2B;CDKN2B-AS1
|
Adenocarcinoma of lung (disorder)
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs1063192
|
CDKN2B;CDKN2B-AS1
|
Glaucoma, Primary Open Angle
|
|
0.050 |
GeneticVariation |
BEFREE |
Stratification analysis by type of glaucoma revealed that rs1063192 polymorphism conferred a protective factor of primary open-angle glaucoma (POAG) and non-POAG.
|
28416752 |
2017 |
|
rs1063192
|
CDKN2B;CDKN2B-AS1
|
Glaucoma, Primary Open Angle
|
|
0.050 |
GeneticVariation |
BEFREE |
Polymorphism rs1063192 in CDKN2B is not a risk factor for POAG in Saudi cohort.
|
27541204 |
2016 |
|
rs1063192
|
CDKN2B;CDKN2B-AS1
|
Glaucoma, Primary Open Angle
|
|
0.050 |
GeneticVariation |
BEFREE |
In addition to confirmation of the association of the chromosome 9p21 locus [rs1063192, P= 5.2 × 10(-11), odds ratio (OR) = 0.75], and 14q23 (rs10483727, P = 9.49 × 10(-8), OR = 0.79) with POAG in Caucasians reported recently, we identified a suggestive-associated locus on 2q21 (rs7588567, P = 3.89 × 10(-7), OR = 0.85).
|
22419738 |
2012 |
|
rs1063192
|
CDKN2B;CDKN2B-AS1
|
Glaucoma, Primary Open Angle
|
|
0.050 |
GeneticVariation |
BEFREE |
However, a significant interactive effect on POAG risk was identified between rs1063192</span> and rs7916697 (P-interaction = 2.80 × 10(-5)).
|
22761751 |
2012 |
|
rs1063192
|
CDKN2B;CDKN2B-AS1
|
Glaucoma, Primary Open Angle
|
|
0.050 |
GeneticVariation |
BEFREE |
SNPs associated with VCDR rs1063192 (CDKN2B) and rs10483727 (SIX1/SIX6) were also associated with POAG (P = 0.0006 and P = 0.0043 for rs1063192 and rs10483727, respectively). rs1063192, associated with smaller VCDR, had a protective effect (odds ratio [OR] = 0.73; 95% confidence interval [CI], 0.58-0.90), whereas rs10483727, associated with larger VCDR, increased POAG risk (OR = 1.33; 95% CI, 1.08-1.65).
|
21398277 |
2011 |
|
rs1063192
|
CDKN2B;CDKN2B-AS1
|
Low Tension Glaucoma
|
|
0.020 |
GeneticVariation |
BEFREE |
In addition, methylation at CpG sites in CDKN2B was also associated with genotype at rs1063192, which is known to confer risk for NTG.
|
29265947 |
2018 |
|
rs1063192
|
CDKN2B;CDKN2B-AS1
|
Low Tension Glaucoma
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs1063192 (CDKN2B) and rs1900004 (ATOH7) seem to be non-IOP-related genetic risk factors for NTG, and the rs1547014 (CHEK2) is a genetic risk factor for HTG.
|
22584021 |
2012 |
|
rs3217992
|
CDKN2B;CDKN2B-AS1
|
Coronary heart disease
|
|
0.010 |
GeneticVariation |
BEFREE |
ANRIL polymorphisms (rs1333049 and rs3217992) in relation to plasma CRP levels among in-patients with CHD.
|
31770616 |
2020 |
|
rs3217992
|
CDKN2B;CDKN2B-AS1
|
Childhood Osteosarcoma
|
|
0.010 |
GeneticVariation |
BEFREE |
RESULTS An allele of the SNP rs3217992 is predictive for susceptibility to osteos</span>arcoma, and it is associated with poorer prognosis of osteos</span>arcoma.
|
30774116 |
2019 |
|
rs3217992
|
CDKN2B;CDKN2B-AS1
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, our results demonstrated that the rs944796 G allele, rs2518723 T allele, rs3217992 T allele frequencies were significantly associated with anti-CCP in RA patients (all <i>P</i> < 0.05).
|
31736958 |
2019 |
|
rs3217992
|
CDKN2B;CDKN2B-AS1
|
Osteosarcoma of bone
|
|
0.010 |
GeneticVariation |
BEFREE |
RESULTS An allele of the SNP rs3217992 is predictive for susceptibility to osteos</span>arcoma, and it is associated with poorer prognosis of osteos</span>arcoma.
|
30774116 |
2019 |
|
rs3217992
|
CDKN2B;CDKN2B-AS1
|
Osteosarcoma
|
|
0.010 |
GeneticVariation |
BEFREE |
RESULTS An allele of the SNP rs3217992 is predictive for susceptibility to osteos</span>arcoma, and it is associated with poorer prognosis of osteos</span>arcoma.
|
30774116 |
2019 |
|
rs3217992
|
CDKN2B;CDKN2B-AS1
|
Secondary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the GA and AA genotypes of rs3217992 in CDKN2A might indicate higher stage and increased risk of lung metastasis of osteosarcoma, resulting in worse prognosis.
|
30774116 |
2019 |
|
rs1063192
|
CDKN2B;CDKN2B-AS1
|
Adult Medulloblastoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We hypothesized that CCDKN2A/B rs1063192 and rs4977756 and also the long noncoding RNA (lncRNA) CDKN2BAS rs2157719 glioma susceptibility polymorphisms identified by genome-wide association studies may contribute to medulloblastoma predisposition.
|
29314442 |
2018 |
|
rs1063192
|
CDKN2B;CDKN2B-AS1
|
Medulloblastoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We hypothesized that CCDKN2A/B rs1063192 and rs4977756 and also the long noncoding RNA (lncRNA) CDKN2BAS rs2157719 glioma susceptibility polymorphisms identified by genome-wide association studies may contribute to medulloblastoma predisposition.
|
29314442 |
2018 |
|
rs1063192
|
CDKN2B;CDKN2B-AS1
|
Childhood Medulloblastoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We hypothesized that CCDKN2A/B rs1063192 and rs4977756 and also the long noncoding RNA (lncRNA) CDKN2BAS rs2157719 glioma susceptibility polymorphisms identified by genome-wide association studies may contribute to medulloblastoma predisposition.
|
29314442 |
2018 |
|
rs3217992
|
CDKN2B;CDKN2B-AS1
|
Periodontitis
|
|
0.010 |
GeneticVariation |
BEFREE |
The primary objectives of the study were to assess, among cardiovascular (CV angiographically proven ≥50% stenosis of a main coronary artery) patients, the impact of ANRIL SNPs rs133049 and rs3217992 on the severity of periodontitis and the previous history of coronary events, as well as on the occurrence of further adverse CV events.
|
29732560 |
2018 |
|
rs3217992
|
CDKN2B;CDKN2B-AS1
|
Severe periodontitis
|
|
0.010 |
GeneticVariation |
BEFREE |
ANRIL SNPs rs133049 and rs3217992 were not associated with severe periodontitis or history of CVD in CV patients.
|
29732560 |
2018 |
|
rs3217992
|
CDKN2B;CDKN2B-AS1
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
ANRIL SNPs rs133049 and rs3217992 were not associated with severe periodontitis or history of CVD in CV patients.
|
29732560 |
2018 |
|
rs3217992
|
CDKN2B;CDKN2B-AS1
|
Childhood Acute Lymphoblastic Leukemia
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNPs rs2811712, rs3731249, rs3217992 and rs2811709 were associated with B-ALL susceptibility in our Spanish population.
|
28481918 |
2017 |
|
rs1063192
|
CDKN2B;CDKN2B-AS1
|
Nasopharyngeal carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results also provide support for associations reported from published NPC GWAS-rs6774494 (P = 1.5 × 10(-12); located in the MECOM gene region), rs9510787 (P = 5.0 × 10(-10); located in the TNFRSF19 gene region), and rs1412829/rs4977756/rs1063192 (P = 2.8 × 10(-8), P = 7.0 × 10(-7), and P = 8.4 × 10(-7), respectively; located in the CDKN2A/B gene region).
|
26545403 |
2016 |
|
rs3217992
|
CDKN2B;CDKN2B-AS1
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the A allele of the rs3217992 SNP was associated with an increased pancreatic cancer risk (ORhet=1.14, 95% CI 1.01-1.27, p=0.026, ORhom=1.30, 95% CI 1.12-1.51, p=0.00049).
|
27486979 |
2016 |
|
rs3217992
|
CDKN2B;CDKN2B-AS1
|
Malignant neoplasm of pancreas
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the A allele of the rs3217992 SNP was associated with an increased pancreatic cancer risk (ORhet=1.14, 95% CI 1.01-1.27, p=0.026, ORhom=1.30, 95% CI 1.12-1.51, p=0.00049).
|
27486979 |
2016 |