rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide association analysis of age-at-onset in Alzheimer's disease.
22005931
2012
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
BEFREE
Collectively, our analysis shows TOMM40 rs2075650 polymorphism is associated with AD susceptibility in Asian, Caucasian, and mixed populations.
27328316
2016
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
BEFREE
Similarly, our evidence suggested that allele A of TOMM40 rs2075650 polymorphism was a risk factor for AD (OR=2.87, 95% CI: 2.46-3. 34, P value <0.001).
26795201
2016
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
BEFREE
Both methods' results showed two identical significant SNPs associated with the A β-42 levels in CSF (rs2075650 at intron region TOMM40 with p-value ≥ 1 × 10-16 and rs439401 in the intergenic region of LOC100129500 and APOC1 with p-value ≥ 1 × 10-9) and highlighted APOC1 and TOMM40, which are well-known genes previously associated with AD .
26576771
2016
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
G
0.900
GeneticVariation
GWASCAT
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
24755620
2014
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
G
0.900
GeneticVariation
GWASDB
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
20885792
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
BEFREE
Our prevalent case study comparing prevalent AD cases (n = 428) with participants with no cognitive impairment (n = 524) revealed a significant association of rs6656401 and rs3818361 (CR1), rs2075650 (TOMM40), rs7561528 (BIN1), and rs3 865444 (CD33) with late-onset AD that were robust to adjustment with age and apolipoprotein E ε4 genotype.
24176626
2014
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
BEFREE
However, Kaplan-Meier survival analyses suggest that AD patients with TOMM40 allele rs2075650 -G have an average age of disease onset of 6 years earlier compared with carriers of the A allele.
27023435
2017
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
22005930
2012
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
19734902
2009
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
21123754
2011
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
19734902
2009
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
19734903
2009
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
BEFREE
Only TOMM40 rs2075650 showed association with clinical AD after adjusting for APOE-ε4 (p = 0.007), but not after multiple test correction (p>0.05).
23573206
2013
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
20061627
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
G
0.900
GeneticVariation
GWASCAT
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
20885792
2010
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
30636644
2019
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
BEFREE
We conclude that rs2075650 in TOMM40 gene may increase the risk of Alzheimer disease .
26572157
2016
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
21460841
2011
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.
29107063
2018
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
21379329
2011
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
BEFREE
The SNPs rs2075650 and rs4420638 were linked to the most replications within a single reclassified phenotype or very similar reclassified phenotypes; both were associated with Alzheimer's disease (AD ).
29942042
2019
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
24770881
2014
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASCAT
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
24770881
2014
rs2075650
×
Entrez Id:
10452
Gene Symbol:
TOMM40
TOMM40
Alzheimer's Disease
0.900
GeneticVariation
GWASDB
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
19136949
2009