DisGeNET - a database of gene-disease associations

SLCO1B1, solute carrier organic anion transporter family member 1B1, 10599

N. diseases: 151; N. variants: 30

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs2417957

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0948008
Disease:

Ischemic stroke

0.700

GeneticVariation

GWASCAT

Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.

26732560

2016

dbSNP:

rs71581941

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0220991
Disease:

Rotor Syndrome

0.700

CausalMutation

CLINVAR

Recessive inheritance of population-specific intronic LINE-1 insertion causes a rotor syndrome phenotype.

25546334

2015

dbSNP:

rs11045879

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0523465
Disease:

Serum albumin measurement

0.700

GeneticVariation

GWASDB

A genome-wide assessment of variability in human serum metabolism.

23281178

2013

dbSNP:

rs4149018

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0007930
Disease:

Chagas Cardiomyopathy

0.700

GeneticVariation

GWASCAT

Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.

24324551

2013

dbSNP:

rs4149056

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0202218
Disease:

Sex hormone binding globulin measurement

0.700

GeneticVariation

GWASCAT

Loci near the identified SNPs included SHBG (rs12150660, 17p13.1, p = 1.8 × 10(-106)), PRMT6 (rs17496332, 1p13.3, p = 1.4 × 10(-11)), GCKR (rs780093, 2p23.3, p = 2.2 × 10(-16)), ZBTB10 (rs440837, 8q21.13, p = 3.4 × 10(-09)), JMJD1C (rs7910927, 10q21.3, p = 6.1 × 10(-35)), SLCO1B1 (rs4149056, 12p12.1, p = 1.9 × 10(-08)), NR2F2 (rs8023580, 15q26.2, p = 8.3 × 10(-12)), ZNF652 (rs2411984, 17q21.32, p = 3.5 × 10(-14)), TDGF3 (rs1573036, Xq22.3, p = 4.1 × 10(-14)), LHCGR (rs10454142, 2p16.3, p = 1.3 × 10(-07)), BAIAP2L1 (rs3779195, 7q21.3, p = 2.7 × 10(-08)), and UGT2B15 (rs293428, 4q13.2, p = 5.5 × 10(-06)).

22829776

2012

dbSNP:

rs4149056

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0007137
Disease:

Squamous cell carcinoma

0.700

GeneticVariation

GWASDB

Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.

23103227

2012

dbSNP:

rs4149056

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C1443016
Disease:

Estradiol level result

0.700

GeneticVariation

GWASDB

A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.

22829776

2012

dbSNP:

rs4149056

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0337434
Disease:

Estradiol measurement

0.700

GeneticVariation

GWASDB

A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.

22829776

2012

dbSNP:

rs71581941

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0220991
Disease:

Rotor Syndrome

0.700

CausalMutation

CLINVAR

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.

22232210

2012

dbSNP:

rs4149081

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0495706
Disease:

elevated blood glucose level

0.700

GeneticVariation

GWASDB

Human metabolic individuality in biomedical and pharmaceutical research.

21886157

2011

dbSNP:

rs4149081

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0337438
Disease:

Glucose measurement

0.700

GeneticVariation

GWASDB

Human metabolic individuality in biomedical and pharmaceutical research.

21886157

2011

dbSNP:

rs4363657

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C1287365
Disease:

Bilirubin level result

0.700

GeneticVariation

GWASDB

Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.

21646302

2011

dbSNP:

rs11045879

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs11045879

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C1287365
Disease:

Bilirubin level result

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs11045885

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs11045885

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C1287365
Disease:

Bilirubin level result

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs12317268

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C1287365
Disease:

Bilirubin level result

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs12317268

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs12366582

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs12366582

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C1287365
Disease:

Bilirubin level result

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs12369881

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs12369881

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C1287365
Disease:

Bilirubin level result

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs12371604

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C1287365
Disease:

Bilirubin level result

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs12371604

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009

dbSNP:

rs1871395

Entrez Id:	10599
Gene Symbol:	SLCO1B1

SLCO1B1

CUI:	C0344395
Disease:

Bilirubin measurement

0.700

GeneticVariation

GWASDB

Genome-wide association meta-analysis for total serum bilirubin levels.

19414484

2009