ADCY5, adenylate cyclase 5, 111

N. diseases: 103; N. variants: 23
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.840 GeneticVariation GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458 2018
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.840 GeneticVariation BEFREE The type 2 diabetes risk rs11708067</span>-A allele showed fewer H3K27ac ChIP-seq reads in human islets, lower transcriptional activity in reporter assays in rodent β-cells (rat 832/13 and mouse MIN6), and increased nuclear protein binding compared with the rs11708067-G allele. 28684635 2017
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.840 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.840 GeneticVariation BEFREE However, altered ADCY5 expression in AT does not seem to be the mechanism underlying the association between rs11708067 and increased T2D risk. 25793868 2015
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.840 GeneticVariation GWASCAT Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. 22693455 2012
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.840 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.840 GeneticVariation GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.840 GeneticVariation GWASDB Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. 22693455 2012
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.840 GeneticVariation BEFREE In addition to previously reported type 2 diabetes risk variants in TCF7L2 and SLC30A8, SNPs in ADCY5 (rs11708067) and GLIS3 (rs7034200) displayed evidence for association with type 2 diabetes, with odds ratios of 1.23 (95% CI: 1.09, 1.39; p = 9.1×10(-4)) and 1.16 (95% CI: 1.05, 1.29; p = 3.49×10(-3)) respectively. 21949744 2011
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.840 GeneticVariation BEFREE Birthweight was inversely associated with the type 2 diabetes risk alleles of ADCY5 rs11708067 (beta = -33 g [95% CI -55, -10], p = 0.004) and CDKAL1 rs7756992 (beta = -22 g [95% CI -43, -1], p = 0.04). 20490451 2010
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0428568
Disease:
Fasting blood glucose measurement 		0.800 GeneticVariation GWASCAT Pleiotropy informed adaptive association test of multiple traits using genome-wide association study summary data. 31021400 2019
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0428568
Disease:
Fasting blood glucose measurement 		G 0.800 GeneticVariation GWASCAT Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. 25631608 2015
dbSNP: rs11717195
rs11717195
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		T 0.800 GeneticVariation GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
dbSNP: rs11717195
rs11717195
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		T 0.800 GeneticVariation GWASCAT Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
dbSNP: rs9883204
rs9883204
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0005612
Disease:
Birth Weight 		C 0.800 GeneticVariation GWASDB New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. 23202124 2013
dbSNP: rs9883204
rs9883204
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0005612
Disease:
Birth Weight 		C 0.800 GeneticVariation GWASCAT New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. 23202124 2013
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C1305855
Disease:
Body mass index 		A 0.800 GeneticVariation GWASCAT A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0428568
Disease:
Fasting blood glucose measurement 		A 0.800 GeneticVariation GWASCAT A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C1305855
Disease:
Body mass index 		0.800 GeneticVariation GWASDB A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0428568
Disease:
Fasting blood glucose measurement 		0.800 GeneticVariation GWASDB Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. 22885924 2012
dbSNP: rs11717195
rs11717195
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		T 0.800 GeneticVariation GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
dbSNP: rs11717195
rs11717195
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.800 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
dbSNP: rs2877716
rs2877716
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0428568
Disease:
Fasting blood glucose measurement 		T 0.800 GeneticVariation GWASCAT A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
dbSNP: rs2877716
rs2877716
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0428568
Disease:
Fasting blood glucose measurement 		0.800 GeneticVariation GWASDB Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. 22885924 2012
dbSNP: rs11708067
rs11708067
Entrez Id: 111
Gene Symbol: ADCY5
ADCY5
CUI: C0428568
Disease:
Fasting blood glucose measurement 		A 0.800 GeneticVariation GWASCAT New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. 20081858 2010