CLCN6, chloride voltage-gated channel 6, 1185

N. diseases: 24; N. variants: 25
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs202102042
rs202102042
Entrez Id: 1185;4878;100379251
Gene Symbol: CLCN6;NPPA;NPPA-AS1
CLCN6;NPPA;NPPA-AS1
CUI: C3810401
Disease:
ATRIAL STANDSTILL 2 		T 0.800 CausalMutation CLINVAR
dbSNP: rs202102042
rs202102042
Entrez Id: 1185;4878;100379251
Gene Symbol: CLCN6;NPPA;NPPA-AS1
CLCN6;NPPA;NPPA-AS1
CUI: C3810401
Disease:
ATRIAL STANDSTILL 2 		0.800 GeneticVariation UNIPROT
dbSNP: rs202102042
rs202102042
Entrez Id: 1185;4878;100379251
Gene Symbol: CLCN6;NPPA;NPPA-AS1
CLCN6;NPPA;NPPA-AS1
CUI: C0871470
Disease:
Systolic Pressure 		T 0.700 GeneticVariation GWASCAT Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. 30578418 2019
dbSNP: rs55857306
rs55857306
Entrez Id: 1185
Gene Symbol: CLCN6
CLCN6
CUI: C0871470
Disease:
Systolic Pressure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs56153133
rs56153133
Entrez Id: 1185
Gene Symbol: CLCN6
CLCN6
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs6669371
rs6669371
Entrez Id: 1185
Gene Symbol: CLCN6
CLCN6
CUI: C0871470
Disease:
Systolic Pressure 		G 0.700 GeneticVariation GWASCAT Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. 30578418 2019
dbSNP: rs13306561
rs13306561
Entrez Id: 1185;4524
Gene Symbol: CLCN6;MTHFR
CLCN6;MTHFR
CUI: C0427418
Disease:
Folic acid measurement, RBC 		0.700 GeneticVariation GWASCAT The 677C→T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish population. 30339177 2018
dbSNP: rs13306561
rs13306561
Entrez Id: 1185;4524
Gene Symbol: CLCN6;MTHFR
CLCN6;MTHFR
CUI: C0001948
Disease:
Alcohol consumption 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs149764880
rs149764880
Entrez Id: 1185
Gene Symbol: CLCN6
CLCN6
CUI: C0428883
Disease:
Diastolic blood pressure 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs149764880
rs149764880
Entrez Id: 1185
Gene Symbol: CLCN6
CLCN6
CUI: C0428886
Disease:
Mean blood pressure 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs149764880
rs149764880
Entrez Id: 1185
Gene Symbol: CLCN6
CLCN6
CUI: C0001948
Disease:
Alcohol consumption 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs17037452
rs17037452
Entrez Id: 1185
Gene Symbol: CLCN6
CLCN6
CUI: C0871470
Disease:
Systolic Pressure 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs17037452
rs17037452
Entrez Id: 1185
Gene Symbol: CLCN6
CLCN6
CUI: C1306620
Disease:
Systolic blood pressure measurement 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs17037452
rs17037452
Entrez Id: 1185
Gene Symbol: CLCN6
CLCN6
CUI: C0428886
Disease:
Mean blood pressure 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs202071545
rs202071545
Entrez Id: 1185
Gene Symbol: CLCN6
CLCN6
CUI: C0871470
Disease:
Systolic Pressure 		0.700 GeneticVariation GWASCAT A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. 29455858 2018
dbSNP: rs202071545
rs202071545
Entrez Id: 1185
Gene Symbol: CLCN6
CLCN6
CUI: C0428883
Disease:
Diastolic blood pressure 		0.700 GeneticVariation GWASCAT A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. 29455858 2018
dbSNP: rs3753584
rs3753584
Entrez Id: 1185;4524
Gene Symbol: CLCN6;MTHFR
CLCN6;MTHFR
CUI: C1305849
Disease:
Diastolic blood pressure measurement 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs3753584
rs3753584
Entrez Id: 1185;4524
Gene Symbol: CLCN6;MTHFR
CLCN6;MTHFR
CUI: C0871470
Disease:
Systolic Pressure 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs3753584
rs3753584
Entrez Id: 1185;4524
Gene Symbol: CLCN6;MTHFR
CLCN6;MTHFR
CUI: C0428886
Disease:
Mean blood pressure 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs3753584
rs3753584
Entrez Id: 1185;4524
Gene Symbol: CLCN6;MTHFR
CLCN6;MTHFR
CUI: C1306620
Disease:
Systolic blood pressure measurement 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs3753584
rs3753584
Entrez Id: 1185;4524
Gene Symbol: CLCN6;MTHFR
CLCN6;MTHFR
CUI: C0428883
Disease:
Diastolic blood pressure 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs5068
rs5068
Entrez Id: 1185;4878;100379251
Gene Symbol: CLCN6;NPPA;NPPA-AS1
CLCN6;NPPA;NPPA-AS1
CUI: C0428883
Disease:
Diastolic blood pressure 		0.700 GeneticVariation GWASCAT A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. 29455858 2018
dbSNP: rs5068
rs5068
Entrez Id: 1185;4878;100379251
Gene Symbol: CLCN6;NPPA;NPPA-AS1
CLCN6;NPPA;NPPA-AS1
CUI: C0871470
Disease:
Systolic Pressure 		0.700 GeneticVariation GWASCAT A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. 29455858 2018
dbSNP: rs6669371
rs6669371
Entrez Id: 1185
Gene Symbol: CLCN6
CLCN6
CUI: C0001948
Disease:
Alcohol consumption 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs6669371
rs6669371
Entrez Id: 1185
Gene Symbol: CLCN6
CLCN6
CUI: C0428883
Disease:
Diastolic blood pressure 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018