TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Disease: Panic Disorder ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1386494
rs1386494
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0030319
Disease:
Panic Disorder 		0.020 GeneticVariation BEFREE Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T-C, CCKR1 246G-A, CCKR2 -215C-A, DRD1 -94G-A and COMT Val158Met, were selected for genotyping based on previous positive findings from genetic association studies in PD. 18832011 2008
dbSNP: rs1386494
rs1386494
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0030319
Disease:
Panic Disorder 		0.020 GeneticVariation BEFREE However, an association with rs1386494 SNP was observed in the subgroup of female patients with pure PD phenotype, indicating a possible gender-specific effect of TPH2 gene variants in PD. 17123728 2007