CCR7, C-C motif chemokine receptor 7, 1236

N. diseases: 320; N. variants: 3
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2228015
rs2228015
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
CUI: C0200635
Disease:
Lymphocyte Count measurement 		C 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs3136685
rs3136685
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
CUI: C1306459
Disease:
Primary malignant neoplasm 		0.010 GeneticVariation BEFREE CCR7 rs3136685 AG+GG (p=0.032) was associated with a 1.52-1.70 fold increase in the risk of high grade cancer (Gleason score≥7) among obese men. 28903065 2017
dbSNP: rs3136685
rs3136685
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
CUI: C0006826
Disease:
Malignant Neoplasms 		0.010 GeneticVariation BEFREE CCR7 rs3136685 AG+GG (p=0.032) was associated with a 1.52-1.70 fold increase in the risk of high grade cancer (Gleason score≥7) among obese men. 28903065 2017
dbSNP: rs3136685
rs3136685
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE Similarly, the SNP barcode of rs12812942-rs2228014-rs3025039 (CD4-CXCR4-VEGF) and rs12812942-rs3136685-rs2228014-rs1801157 (CD4- CCR7-CXCR4-CXCL12) with specific genotype patterns (AT-CC-CC and AT-AG-CC-GG) among three and four combinational SNPs were significantly low in breast cancer occurrence. 19196101 2009
dbSNP: rs3136685
rs3136685
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE Similarly, the SNP barcode of rs12812942-rs2228014-rs3025039 (CD4-CXCR4-VEGF) and rs12812942-rs3136685-rs2228014-rs1801157 (CD4- CCR7-CXCR4-CXCL12) with specific genotype patterns (AT-CC-CC and AT-AG-CC-GG) among three and four combinational SNPs were significantly low in breast cancer occurrence. 19196101 2009
dbSNP: rs3136687
rs3136687
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
CUI: C0023434
Disease:
Chronic Lymphocytic Leukemia 		0.010 GeneticVariation BEFREE After adjustment for multiple testing, we found a strong association between CLL risk and six genetic variants: CCNH (rs2266690, V270A), APAF1 (rs17028658, 3'region), IL16 (rs4505265, first intron), CASP8 (rs1045485, D302H), NOS2A (rs2779251, promoter), and CCR7 (rs3136687, intron 1). 19074885 2008