rs4680
|
COMT;MIR4761
|
Unipolar Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study.
|
15583702 |
2005 |
rs4680
|
COMT;MIR4761
|
Unipolar Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Effect of the COMT val158met polymorphism on white matter connectivity in patients with major depressive disorder.
|
23618651 |
2013 |
rs4680
|
COMT;MIR4761
|
Unipolar Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotyped for the functional COMT val158met polymorphism and characterized for clinical response to antidepressive pharmacological treatment as measured by intra-individual changes of Hamilton Depression (HAM-D-21) scores over 6 weeks.
|
17522626 |
2008 |
rs4680
|
COMT;MIR4761
|
Unipolar Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, the effect of COMT val158met on response to electroconvulsive therapy (ECT) was analyzed in a sample of 104 Caucasian patients (f = 71, m = 33) with pharmacologically treatment-resistant Major Depression.
|
19309019 |
2010 |
rs4680
|
COMT;MIR4761
|
Unipolar Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients with major depression.
|
24555772 |
2014 |
rs4680
|
COMT;MIR4761
|
Unipolar Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity.
|
26803486 |
2016 |
rs4680
|
COMT;MIR4761
|
Unipolar Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: the role of gender.
|
26813412 |
2016 |
rs4680
|
COMT;MIR4761
|
Unipolar Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD).
|
21600957 |
2011 |
rs4680
|
COMT;MIR4761
|
Unipolar Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
Responses to venlafaxine treatment in major depressive disorder were stratified by COMT genotypes (Val158Met, rs4680) in a randomized, double-blind, placebo-controlled clinical trial.
|
23706899 |
2013 |
rs4680
|
COMT;MIR4761
|
Unipolar Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
This effect of rs4680 is similar to its observed influence on response to serotonergic and noradrenergic drug treatments in major depressive disorder.
|
19520435 |
2010 |
rs4680
|
COMT;MIR4761
|
Unipolar Depression
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |