COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Pain ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs165774
rs165774
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0030193
Disease:
Pain 		0.040 GeneticVariation BEFREE Multivariate linear regression identified sex and the rs165774 COMT polymorphism as the determinants of electric pain sensitivity, whereas TMD accounts for the variability in the cold response. 29550002 2018
dbSNP: rs165774
rs165774
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0030193
Disease:
Pain 		0.040 GeneticVariation BEFREE AA genotype of rs165774 could be a significant risk factor for the development of TMD and TMD pain, while AA genotype of rs6269 presents less postoperative chronic TMD pain and acute pain at a dental extraction site. 27792797 2017
dbSNP: rs165774
rs165774
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0030193
Disease:
Pain 		0.040 GeneticVariation BEFREE They also established that the pain-protective A allele of rs165774 coincides with lower COMT activity, suggesting contribution to decreased pain sensitivity through increased dopaminergic rather than decreased adrenergic tone, characteristic of reference isoforms. 26207649 2015
dbSNP: rs165774
rs165774
Entrez Id: 1312
Gene Symbol: COMT
COMT
CUI: C0030193
Disease:
Pain 		0.040 GeneticVariation BEFREE SNPs rs887200 and rs165774 located in the untranslated regions of the gene had the strongest effects on pain sensitivity. 24343288 2013