COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Major Depressive Disorder ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs749437638
rs749437638
Entrez Id: 421;1312
Gene Symbol: ARVCF;COMT
ARVCF;COMT
CUI: C1269683
Disease:
Major Depressive Disorder 		0.010 GeneticVariation BEFREE In several previous biochemical and genetic studies, the Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) and the C677T polymorphism of Methylenetetrahydrofolate reductase (MTHFR) have been suggested to be involved in the pathogenesis as well as the treatment response of major depressive disorder (MDD), but the results have been inconsistent. 24751310 2014