PPARGC1B, PPARG coactivator 1 beta, 133522

N. diseases: 102; N. variants: 16
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs109077
rs109077
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0751676
Disease:
Basal Cell Cancer 		T 0.700 GeneticVariation GWASCAT Combined analysis of keratinocyte cancers identifies novel genome-wide loci. 31174203 2019
dbSNP: rs109077
rs109077
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0007117
Disease:
Basal cell carcinoma 		T 0.700 GeneticVariation GWASCAT Combined analysis of keratinocyte cancers identifies novel genome-wide loci. 31174203 2019
dbSNP: rs109077
rs109077
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0206710
Disease:
Basal Cell Neoplasm 		T 0.700 GeneticVariation GWASCAT Combined analysis of keratinocyte cancers identifies novel genome-wide loci. 31174203 2019
dbSNP: rs251464
rs251464
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0153535
Disease:
Malignant melanoma of skin of upper limb 		0.700 GeneticVariation GWASCAT Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. 30429480 2018
dbSNP: rs251464
rs251464
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0151779
Disease:
Cutaneous Melanoma 		0.700 GeneticVariation GWASCAT Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. 30429480 2018
dbSNP: rs251464
rs251464
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0406208
Disease:
Suntan 		C 0.700 GeneticVariation GWASCAT Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure. 29739929 2018
dbSNP: rs251464
rs251464
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0153536
Disease:
Malignant melanoma of skin of lower limb 		0.700 GeneticVariation GWASCAT Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways. 30429480 2018
dbSNP: rs251468
rs251468
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0025209
Disease:
Melanosis 		C 0.700 GeneticVariation GWASCAT Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations. 29895819 2018
dbSNP: rs251464
rs251464
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0042900
Disease:
Vitiligo 		0.700 GeneticVariation GWASCAT Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants. 27723757 2016
dbSNP: rs17110429
rs17110429
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs17110429
rs17110429
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0428474
Disease:
Serum LDL cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs9285640
rs9285640
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C3547188
Disease:
response to fenofibrate 		G 0.700 GeneticVariation GWASDB Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate. 22890011 2012
dbSNP: rs7732671
rs7732671
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0678222
Disease:
Breast Carcinoma 		0.020 GeneticVariation BEFREE Pro 12Ala and Ala203Pro polymorphisms did not modify the association between the iAs methylation capacity and BC. 27557380 2016
dbSNP: rs7732671
rs7732671
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.020 GeneticVariation BEFREE Pro 12Ala and Ala203Pro polymorphisms did not modify the association between the iAs methylation capacity and BC. 27557380 2016
dbSNP: rs7732671
rs7732671
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.020 GeneticVariation BEFREE The genotype-combination analysis of the associated PPARGC1A Thr612Met variant and the associated PPARGC1B Ala203Pro variant suggests an allele dose-dependent breast cancer risk (P(trend) = 0.0004). 16704985 2006
dbSNP: rs7732671
rs7732671
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0678222
Disease:
Breast Carcinoma 		0.020 GeneticVariation BEFREE The genotype-combination analysis of the associated PPARGC1A Thr612Met variant and the associated PPARGC1B Ala203Pro variant suggests an allele dose-dependent breast cancer risk (P(trend) = 0.0004). 16704985 2006
dbSNP: rs1076064
rs1076064
Entrez Id: 133522;494327
Gene Symbol: PPARGC1B;MIR378A
PPARGC1B;MIR378A
CUI: C0376358
Disease:
Malignant neoplasm of prostate 		0.010 GeneticVariation BEFREE Since miRNA-based mechanisms are shown to be involved in the pathogenesis of prostate cancer (PCa), the aim of the present study was to evaluate the effect of rs4938723, rs1076064 and rs4705343 occurring in regulatory regions of miR-34b/c, miR-143/145 and miR-378, respectively, on PCa risk and progression in Serbian population. 31423132 2019
dbSNP: rs1076064
rs1076064
Entrez Id: 133522;494327
Gene Symbol: PPARGC1B;MIR378A
PPARGC1B;MIR378A
CUI: C0600139
Disease:
Prostate carcinoma 		0.010 GeneticVariation BEFREE Since miRNA-based mechanisms are shown to be involved in the pathogenesis of prostate cancer (PCa), the aim of the present study was to evaluate the effect of rs4938723, rs1076064 and rs4705343 occurring in regulatory regions of miR-34b/c, miR-143/145 and miR-378, respectively, on PCa risk and progression in Serbian population. 31423132 2019
dbSNP: rs17572019
rs17572019
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.010 GeneticVariation BEFREE We selected the <i>PPARG</i> rs3856806 C>T, <i>PPARGC1A</i> rs2970847 C>T, rs8192678 C>T, rs3736265 G>A and <i>PPARGC1B</i> rs7732671 G>C and rs17572019 G>A SNPs to assess the relationship between <i>PPARG, PPARGC1A, PPARGC1B</i> their variants and risk of CRC. 30838172 2019
dbSNP: rs17572019
rs17572019
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C2239176
Disease:
Liver carcinoma 		0.010 GeneticVariation BEFREE In this study, we selected <i>PPARG</i> rs1801282 C>G and rs3856806 C>T, <i>PPARGC1A</i> rs2970847 C>T, and <i>PPARGC1B</i> rs7732671 G>C and rs17572019 G>A single-nucleotide polymorphisms to explore the relationship between these polymorphisms and hepatocellular carcinoma (HCC) risk. 30122956 2018
dbSNP: rs62382272
rs62382272
Entrez Id: 133522;494327
Gene Symbol: PPARGC1B;MIR378A
PPARGC1B;MIR378A
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE After multivariate logistic regression analysis, we found that three CpG-SNPs: rs1190983, rs155247, and rs62382272, were significantly associated with breast-cancer susceptibility in the population (Additive model: rs1190983: adjusted OR = 0.88, 95% CI: 0.79-0.99, P = 0.034; rs155247: adjusted OR = 0.83, 95% CI: 0.74-0.93, P = 0.002; rs62382272: adjusted OR = 1.24, 95% CI: 1.04-1.47, P = 0.016). eQTL analysis showed that these three SNPs were correlated with the expression of the related miRNAs in TCGA breast cancer tissues (P = 0.006,0.009,0.001 for rs1190983, rs155247, and rs62382272). 29374520 2018
dbSNP: rs62382272
rs62382272
Entrez Id: 133522;494327
Gene Symbol: PPARGC1B;MIR378A
PPARGC1B;MIR378A
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE After multivariate logistic regression analysis, we found that three CpG-SNPs: rs1190983, rs155247, and rs62382272, were significantly associated with breast-cancer susceptibility in the population (Additive model: rs1190983: adjusted OR = 0.88, 95% CI: 0.79-0.99, P = 0.034; rs155247: adjusted OR = 0.83, 95% CI: 0.74-0.93, P = 0.002; rs62382272: adjusted OR = 1.24, 95% CI: 1.04-1.47, P = 0.016). eQTL analysis showed that these three SNPs were correlated with the expression of the related miRNAs in TCGA breast cancer tissues (P = 0.006,0.009,0.001 for rs1190983, rs155247, and rs62382272). 29374520 2018
dbSNP: rs7732671
rs7732671
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C2239176
Disease:
Liver carcinoma 		0.010 GeneticVariation BEFREE In this study, we selected <i>PPARG</i> rs1801282 C>G and rs3856806 C>T, <i>PPARGC1A</i> rs2970847 C>T, and <i>PPARGC1B</i> rs7732671 G>C and rs17572019 G>A single-nucleotide polymorphisms to explore the relationship between these polymorphisms and hepatocellular carcinoma (HCC) risk. 30122956 2018
dbSNP: rs17572019
rs17572019
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation BEFREE Haplotype comparison analysis indicated that CTTCGGG and CTCTGGG haplotypes with the order of PPARG rs1801282 C>G, PPARG rs3856806 C>T, PPARGC1A rs8192678 C>T, PPARGC1A rs2970847 C>T, PPARGC1A rs3736265 G>A, PPARGC1B rs7732671 G>C and PPARGC1B rs17572019 G>A polymorphisms in gene position significantly increased the risk of T2DM. 28418876 2017
dbSNP: rs7732671
rs7732671
Entrez Id: 133522
Gene Symbol: PPARGC1B
PPARGC1B
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation BEFREE Haplotype comparison analysis indicated that CTTCGGG and CTCTGGG haplotypes with the order of PPARG rs1801282 C>G, PPARG rs3856806 C>T, PPARGC1A rs8192678 C>T, PPARGC1A rs2970847 C>T, PPARGC1A rs3736265 G>A, PPARGC1B rs7732671 G>C and PPARGC1B rs17572019 G>A polymorphisms in gene position significantly increased the risk of T2DM. 28418876 2017