|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
This study aimed to examine whether functional single nucleotide polymorphisms (SNPs) in 1976T > C (ADORA2A; rs5751876) and -163C > A (CYP1A2; rs762551) influence the effect of caffeine on the postprandial glucose (GLU) response to a carbohydrate meal.
|
31324842 |
2019 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
ADORA2A has been shown to be responsible for the wakefulness-promoting effect of caffeine and the 1976T>C genotype (SNP rs5751876, formerly 1083T>C) to contribute to individual sensitivity to caffeine effects on sleep.
|
31817803 |
2019 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes.
|
28215251 |
2017 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
We collected information on lifetime coffee drinking and we studied two genes: ADORA2A, which encodes the major receptor activity of caffeine in the brain (variants rs5751876 and rs3032740), and CYP1A2, which encodes the major rate-limiting step of caffeine metabolism (variants rs35694136 and rs762551).
|
18759349 |
2008 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
Here we show in humans that (1) habitual caffeine consumption is associated with reduced sleep quality in self-rated caffeine-sensitive individuals, but not in caffeine-insensitive individuals; (2) the distribution of distinct c.1083T>C genotypes of the adenosine A2A receptor gene (ADORA2A) differs between caffeine-sensitive and -insensitive adults; and (3) the ADORA2A c.1083T>C genotype determines how closely the caffeine-induced changes in brain electrical activity during sleep resemble the alterations observed in patients with insomnia.
|
17329997 |
2007 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.070 |
GeneticVariation |
BEFREE |
We examined whether genetic variability in caffeine metabolism [cytochrome P450 1A2 (CYP1A2) -163A-->C] or the main target of caffeine action in the nervous system [adenosine A(2A) receptor (ADORA2A) 1083C-->T] is associated with habitual caffeine consumption.
|
17616786 |
2007 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation |
BEFREE |
Here, it was investigated whether the adenosine 2 A receptor gene (ADORA2A) 1976T/C (rs5751876) variant - previously associated with anxiety disorders and anxiety-related phenotypes as well as general attentional efficiency -was involved in the regulation of this network.
|
27262510 |
2016 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation |
BEFREE |
The complex pathogenesis of anxiety and panic disorder in particular has been suggested to be influenced by genetic factors such as the adenosine A2A receptor gene (ADORA2A) 1976T>C polymorphism (rs5751876) as well as neuropsychological factors such as early information processing deficits.
|
22940476 |
2013 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation |
BEFREE |
Results showed greater susceptibility to caffeine-induced anxiety, but not lower habitual caffeine intake (indeed coffee intake was higher), in the rs5751876 TT genotype group, and a reduced anxiety response in MH vs NL participants irrespective of genotype.
|
20520601 |
2010 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation |
BEFREE |
A variant within the corresponding ADORA2A gene (rs5751876) increased the risk for panic disorder (PD), for elevated anxiety during challenge tests in healthy probands and for anxiety-related arousal in blood-injury phobia.
|
20334879 |
2010 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.050 |
GeneticVariation |
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety
|
|
0.040 |
GeneticVariation |
BEFREE |
The complex pathogenesis of anxiety and panic disorder in particular has been suggested to be influenced by genetic factors such as the adenosine A2A receptor gene (ADORA2A) 1976T>C polymorphism (rs5751876) as well as neuropsychological factors such as early information processing deficits.
|
22940476 |
2013 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety
|
|
0.040 |
GeneticVariation |
BEFREE |
A variant within the corresponding ADORA2A gene (rs5751876) increased the risk for panic disorder (PD), for elevated anxiety during challenge tests in healthy probands and for anxiety-related arousal in blood-injury phobia.
|
20334879 |
2010 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety
|
|
0.040 |
GeneticVariation |
BEFREE |
Results showed greater susceptibility to caffeine-induced anxiety, but not lower habitual caffeine intake (indeed coffee intake was higher), in the rs5751876 TT genotype group, and a reduced anxiety response in MH vs NL participants irrespective of genotype.
|
20520601 |
2010 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety
|
|
0.040 |
GeneticVariation |
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.020 |
GeneticVariation |
BEFREE |
An association between the ADORA2A rs2298383 TT genotype with the presence of anxiety disorders (P = .004) and an interaction between ADORA2A-DRD2 risk haplotypes with the same outcome (P = .005) was detected.
|
30946941 |
2019 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Sleeplessness
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs5751876 T allele was associated with a decreased risk of sleep complaints (Ora = 0.7 [0.3-0.9]) and insomnia (Ora = 0.5 [0.3-0.9]).
|
31817803 |
2019 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Panic Disorder
|
|
0.020 |
GeneticVariation |
BEFREE |
The complex pathogenesis of anxiety and panic disorder in particular has been suggested to be influenced by genetic factors such as the adenosine A2A receptor gene (ADORA2A) 1976T>C polymorphism (rs5751876) as well as neuropsychological factors such as early information processing deficits.
|
22940476 |
2013 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Panic Disorder
|
|
0.020 |
GeneticVariation |
BEFREE |
We were indeed able to replicate rs5751876 as risk factor for PD, particularly PD with agoraphobia.
|
20334879 |
2010 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.020 |
GeneticVariation |
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Sleeplessness
|
|
0.020 |
GeneticVariation |
BEFREE |
Here we show in humans that (1) habitual caffeine consumption is associated with reduced sleep quality in self-rated caffeine-sensitive individuals, but not in caffeine-insensitive individuals; (2) the distribution of distinct c.1083T>C genotypes of the adenosine A2A receptor gene (ADORA2A) differs between caffeine-sensitive and -insensitive adults; and (3) the ADORA2A c.1083T>C genotype determines how closely the caffeine-induced changes in brain electrical activity during sleep resemble the alterations observed in patients with insomnia.
|
17329997 |
2007 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Sleeplessness
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the rs2298383 T and rs4822492 G alleles were associated with higher risk of sleep complaints (Ora = 1.9 [1.2-3.1] and Ora = 1.5 [1.1-2.1]) and insomnia (Ora = 1.5 [1.3-2.5] and Ora = 1.9 [1.3-3.2).
|
31817803 |
2019 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Depressed mood
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data support an important role for ADORA2A rs2298383 SNP in clinical heterogeneity associated with depression.
|
30511252 |
2019 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Depressive disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data support an important role for ADORA2A rs2298383 SNP in clinical heterogeneity associated with depression.
|
30511252 |
2019 |