DisGeNET - a database of gene-disease associations

CR1, complement C3b/C4b receptor 1 (Knops blood group), 1378

N. diseases: 129; N. variants: 58

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs3818361

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.880

GeneticVariation

GWASDB

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

21460841

2011

dbSNP:

rs3818361

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.880

GeneticVariation

GWASCAT

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

21460840

2011

dbSNP:

rs3818361

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.880

GeneticVariation

BEFREE

Meta-analysis of available studies (n = 31,771 individuals), including previous studies and public genome-wide association study resources (Alzheimer's Disease Neuroimaging Initiative, Translational Genomics Research Institute, and Multi-site Collaborative Study for Genotype-Phenotype Associations in Alzheimer's Disease), strongly supports the effect of rs3818361 (odds ratio = 1.180, 95% confidence interval: 1.113-1.252, P < 2.99E-8) and suggests the existence of between-study heterogeneity (P < .05).

21784344

2011

dbSNP:

rs3818361

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.880

GeneticVariation

BEFREE

Unadjusted, CLU (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.85-0.96 for single-nucleotide polymorphism [SNP] rs11136000), CR1 (OR, 1.14; 95% CI, 1.07-1.22; SNP rs3818361), and PICALM (OR, 0.89; 95% CI, 0.84-0.94, SNP rs3851179) were associated with AD in white individuals.

20697030

2010

dbSNP:

rs3818361

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.880

GeneticVariation

BEFREE

The results revealed that there were significant differences in genotype (P=0.02) and allele (P=0.007) frequencies of the SNP rs6656401 but no in rs3818361 between AD patients and controls.

20558149

2010

dbSNP:

rs3818361

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.880

GeneticVariation

GWASCAT

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.

19734903

2009

dbSNP:

rs3818361

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.880

GeneticVariation

GWASDB

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.

19734903

2009

dbSNP:

rs6701713

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.810

GeneticVariation

GWASCAT

GWAS on family history of Alzheimer's disease.

29777097

2018

dbSNP:

rs6701713

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.810

GeneticVariation

BEFREE

In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in MTHFR (rs1801133), PICALM (3851719), CLU (rs11136000), and CR1 (rs6701713) are associated with AD.

25359311

2015

dbSNP:

rs6701713

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.810

GeneticVariation

GWASCAT

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

21460841

2011

dbSNP:

rs6701713

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.810

GeneticVariation

GWASDB

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

21460841

2011

dbSNP:

rs4844610

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.710

GeneticVariation

BEFREE

Individuals with F/S genotype had a 1.8 times increased risk for AD compared with F/F genotype (p-adjusted = 0.003), while rs4844610 was only marginally significant (p-adjusted = 0.024).

22819390

2012

dbSNP:

rs4844610

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.710

GeneticVariation

GWASDB

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

21460841

2011

dbSNP:

rs2093760

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASCAT

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.

30617256

2019

dbSNP:

rs12036785

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASCAT

GWAS on family history of Alzheimer's disease.

29777097

2018

dbSNP:

rs679515

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0002395
Disease:

Alzheimer's Disease

0.700

GeneticVariation

GWASCAT

A novel Alzheimer disease locus located near the gene encoding tau protein.

25778476

2016

dbSNP:

rs10429953

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0201657
Disease:

C-reactive protein measurement

0.700

GeneticVariation

GWASDB

A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

22291609

2012

dbSNP:

rs10779330

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0201657
Disease:

C-reactive protein measurement

0.700

GeneticVariation

GWASDB

A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

22291609

2012

dbSNP:

rs10863358

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0201657
Disease:

C-reactive protein measurement

0.700

GeneticVariation

GWASDB

A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

22291609

2012

dbSNP:

rs11117956

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0201657
Disease:

C-reactive protein measurement

0.700

GeneticVariation

GWASDB

A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

22291609

2012

dbSNP:

rs11117959

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0201657
Disease:

C-reactive protein measurement

0.700

GeneticVariation

GWASDB

A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

22291609

2012

dbSNP:

rs11118131

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0201657
Disease:

C-reactive protein measurement

0.700

GeneticVariation

GWASDB

A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

22291609

2012

dbSNP:

rs11118135

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0201657
Disease:

C-reactive protein measurement

0.700

GeneticVariation

GWASDB

A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

22291609

2012

dbSNP:

rs11118136

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0201657
Disease:

C-reactive protein measurement

0.700

GeneticVariation

GWASDB

A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

22291609

2012

dbSNP:

rs11118157

Entrez Id:	1378
Gene Symbol:	CR1

CR1

CUI:	C0201657
Disease:

C-reactive protein measurement

0.700

GeneticVariation

GWASDB

A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

22291609

2012