Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6740584
rs6740584
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0871470
Disease:
Systolic Pressure
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs2360970
rs2360970
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0871470
Disease:
Systolic Pressure
G 0.700 GeneticVariation GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017
dbSNP: rs2360970
rs2360970
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0428883
Disease:
Diastolic blood pressure
G 0.700 GeneticVariation GWASCAT Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation. 27841878 2017
dbSNP: rs6740584
rs6740584
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C1269683
Disease:
Major Depressive Disorder
0.020 GeneticVariation BEFREE Individuals carrying the T- allele of rs5443 (CC), A- allele of rs2253206 (GG), T- allele of rs2551941 (AA), C- allele of rs6740584 (TT) or G- allele of rs11904814 (TT) conferred susceptibility to MD in subjects only exposed to high-negative life events. 28225778 2017
dbSNP: rs6740584
rs6740584
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C1269683
Disease:
Major Depressive Disorder
0.020 GeneticVariation BEFREE The primary aim of this study was to investigate whether a set of single nucleotide polymorphisms (SNPs) within two genes implicated in neuroplasticity and inflammatory processes (the mitogen activated protein kinase 1, MAPK1 (rs3810608, rs6928, rs13515 and rs8136867), and the cyclic AMP responsive element binding protein 1, CREB1 (rs889895, rs6740584, rs2551922 and rs2254137)) was associated with antidepressant treatment resistance (according to two different definitions), in 285 Major Depressive Disorder (MDD) patients. 23537502 2013
dbSNP: rs6785
rs6785
Entrez Id: 1385;151194
Gene Symbol: CREB1;METTL21A
CREB1;METTL21A
CUI: C0006287
Disease:
Bronchopulmonary Dysplasia
0.010 GeneticVariation BEFREE In the present study, we further expanded our analyses of rs2709370 and rs6785 in multiple BPD, SCZ and MDD data sets, including the published Psychiatric Genomics Consortium (PGC) genome-wide association study, the samples used in our previous CREB1 study, and six additional cohorts (three new BPD samples, two new SCZ samples and one new MDD sample). 29158582 2018
dbSNP: rs6785
rs6785
Entrez Id: 1385;151194
Gene Symbol: CREB1;METTL21A
CREB1;METTL21A
CUI: C0006012
Disease:
Borderline Personality Disorder
0.010 GeneticVariation BEFREE In the present study, we further expanded our analyses of rs2709370 and rs6785 in multiple BPD, SCZ and MDD data sets, including the published Psychiatric Genomics Consortium (PGC) genome-wide association study, the samples used in our previous CREB1 study, and six additional cohorts (three new BPD samples, two new SCZ samples and one new MDD sample). 29158582 2018
dbSNP: rs6785
rs6785
Entrez Id: 1385;151194
Gene Symbol: CREB1;METTL21A
CREB1;METTL21A
CUI: C0036341
Disease:
Schizophrenia
0.010 GeneticVariation BEFREE Although the associations of both CREB1 SNPs with each illness were not replicated in the new cohorts (BPD analysis in 871 cases and 1089 controls (rs2709370, P=0.0611; rs6785, P=0.0544); SCZ analysis in 1273 cases and 1072 controls (rs2709370, P=0.230; rs6785, P=0.661); and MDD analysis in 129 cases and 100 controls (rs2709370, P=0.114; rs6785, P=0.188)), an overall meta-analysis of all included samples suggested that both SNPs were significantly associated with increased risk of BPD (11 105 cases and 51 331 controls; rs2709370, P=2.33 × 10<sup>-4</sup>; rs6785, P=6.33 × 10<sup>-5</sup>), SCZ (34 913 cases and 44 528 controls; rs2709370, P=3.96 × 10<sup>-5</sup>; rs6785, P=2.44 × 10<sup>-5</sup>) and MDD (9369 cases and 9619 controls; rs2709370, P=0.0144; rs6785, P=0.0314), with the same direction of allelic effects across diagnostic categories. 29158582 2018
dbSNP: rs6785
rs6785
Entrez Id: 1385;151194
Gene Symbol: CREB1;METTL21A
CREB1;METTL21A
CUI: C1269683
Disease:
Major Depressive Disorder
0.010 GeneticVariation BEFREE Although the associations of both CREB1 SNPs with each illness were not replicated in the new cohorts (BPD analysis in 871 cases and 1089 controls (rs2709370, P=0.0611; rs6785, P=0.0544); SCZ analysis in 1273 cases and 1072 controls (rs2709370, P=0.230; rs6785, P=0.661); and MDD analysis in 129 cases and 100 controls (rs2709370, P=0.114; rs6785, P=0.188)), an overall meta-analysis of all included samples suggested that both SNPs were significantly associated with increased risk of BPD (11 105 cases and 51 331 controls; rs2709370, P=2.33 × 10<sup>-4</sup>; rs6785, P=6.33 × 10<sup>-5</sup>), SCZ (34 913 cases and 44 528 controls; rs2709370, P=3.96 × 10<sup>-5</sup>; rs6785, P=2.44 × 10<sup>-5</sup>) and MDD (9369 cases and 9619 controls; rs2709370, P=0.0144; rs6785, P=0.0314), with the same direction of allelic effects across diagnostic categories. 29158582 2018
dbSNP: rs11904814
rs11904814
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C1269683
Disease:
Major Depressive Disorder
0.010 GeneticVariation BEFREE Individuals carrying the T- allele of rs5443 (CC), A- allele of rs2253206 (GG), T- allele of rs2551941 (AA), C- allele of rs6740584 (TT) or G- allele of rs11904814 (TT) conferred susceptibility to MD in subjects only exposed to high-negative life events. 28225778 2017
dbSNP: rs11904814
rs11904814
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0041696
Disease:
Unipolar Depression
0.010 GeneticVariation BEFREE Individuals carrying the T- allele of rs5443 (CC), A- allele of rs2253206 (GG), T- allele of rs2551941 (AA), C- allele of rs6740584 (TT) or G- allele of rs11904814 (TT) conferred susceptibility to MD in subjects only exposed to high-negative life events. 28225778 2017
dbSNP: rs2254137
rs2254137
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C2063866
Disease:
Depressive Disorder, Treatment-Resistant
0.010 GeneticVariation BEFREE The associations between ZNF804A rs7603001 and response, CREB1 rs2254137 and remission were replicated, as well as CHL1 rs2133402 and lower risk of TRD. 28260126 2017
dbSNP: rs6740584
rs6740584
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0041696
Disease:
Unipolar Depression
0.010 GeneticVariation BEFREE Individuals carrying the T- allele of rs5443 (CC), A- allele of rs2253206 (GG), T- allele of rs2551941 (AA), C- allele of rs6740584 (TT) or G- allele of rs11904814 (TT) conferred susceptibility to MD in subjects only exposed to high-negative life events. 28225778 2017
dbSNP: rs35349697
rs35349697
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0524662
Disease:
Opiate Addiction
0.010 GeneticVariation BEFREE One SNP in exon 3, rs35349697, demonstrated a significant correlation with opioid addiction as well as with alcohol addiction. 24704376 2014
dbSNP: rs35349697
rs35349697
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C1527402
Disease:
Narcotic Dependence
0.010 GeneticVariation BEFREE A novel SNP, also located in exon 3, was identified which showed epistatic interaction with rs35349697 to decrease susceptibility to narcotic addiction in the population. 24704376 2014
dbSNP: rs35349697
rs35349697
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0001973
Disease:
Alcoholic Intoxication, Chronic
0.010 GeneticVariation BEFREE One SNP in exon 3, rs35349697, demonstrated a significant correlation with opioid addiction as well as with alcohol addiction. 24704376 2014
dbSNP: rs2254137
rs2254137
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C1269683
Disease:
Major Depressive Disorder
0.010 GeneticVariation BEFREE The primary aim of this study was to investigate whether a set of single nucleotide polymorphisms (SNPs) within two genes implicated in neuroplasticity and inflammatory processes (the mitogen activated protein kinase 1, MAPK1 (rs3810608, rs6928, rs13515 and rs8136867), and the cyclic AMP responsive element binding protein 1, CREB1 (rs889895, rs6740584, rs2551922 and rs2254137)) was associated with antidepressant treatment resistance (according to two different definitions), in 285 Major Depressive Disorder (MDD) patients. 23537502 2013
dbSNP: rs2551922
rs2551922
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C1269683
Disease:
Major Depressive Disorder
0.010 GeneticVariation BEFREE The primary aim of this study was to investigate whether a set of single nucleotide polymorphisms (SNPs) within two genes implicated in neuroplasticity and inflammatory processes (the mitogen activated protein kinase 1, MAPK1 (rs3810608, rs6928, rs13515 and rs8136867), and the cyclic AMP responsive element binding protein 1, CREB1 (rs889895, rs6740584, rs2551922 and rs2254137)) was associated with antidepressant treatment resistance (according to two different definitions), in 285 Major Depressive Disorder (MDD) patients. 23537502 2013
dbSNP: rs2709377
rs2709377
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0036341
Disease:
Schizophrenia
0.010 GeneticVariation BEFREE The present study explores whether some single nucleotide polymorphisms (SNPs) within CREB1 (rs2709377 and rs6740584), CREBBP (rs2239317, rs2239316, rs3025702, rs130021, rs130005, rs129974 and rs9392) and CREM (rs1148247, rs4934735, rs12775799, rs6481941 and rs16935888) could be associated with schizophrenia (SKZ) and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. 22198373 2012
dbSNP: rs387906617
rs387906617
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0000768
Disease:
Congenital Abnormality
0.010 GeneticVariation BEFREE A p.D116G mutation in CREB1 leads to novel multiple malformation syndrome resembling CrebA knockout mouse. 22267179 2012
dbSNP: rs387906617
rs387906617
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0302142
Disease:
Deformity
0.010 GeneticVariation BEFREE A p.D116G mutation in CREB1 leads to novel multiple malformation syndrome resembling CrebA knockout mouse. 22267179 2012
dbSNP: rs6740584
rs6740584
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0036341
Disease:
Schizophrenia
0.010 GeneticVariation BEFREE The present study explores whether some single nucleotide polymorphisms (SNPs) within CREB1 (rs2709377 and rs6740584), CREBBP (rs2239317, rs2239316, rs3025702, rs130021, rs130005, rs129974 and rs9392) and CREM (rs1148247, rs4934735, rs12775799, rs6481941 and rs16935888) could be associated with schizophrenia (SKZ) and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. 22198373 2012
dbSNP: rs11904814
rs11904814
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0011581
Disease:
Depressive disorder
0.010 GeneticVariation BEFREE The major findings were associations of TPH2 (rs12229394) with depression accompanied by fatigue in women and CREB1 (rs11904814) with depression alone in men. 19548263 2010
dbSNP: rs11904814
rs11904814
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0011570
Disease:
Mental Depression
0.010 GeneticVariation BEFREE The major findings were associations of TPH2 (rs12229394) with depression accompanied by fatigue in women and CREB1 (rs11904814) with depression alone in men. 19548263 2010
dbSNP: rs11904814
rs11904814
Entrez Id: 1385
Gene Symbol: CREB1
CREB1
CUI: C0344315
Disease:
Depressed mood
0.010 GeneticVariation BEFREE The major findings were associations of TPH2 (rs12229394) with depression accompanied by fatigue in women and CREB1 (rs11904814) with depression alone in men. 19548263 2010