CTSH, cathepsin H, 1512

N. diseases: 63; N. variants: 6
Disease: Proliferative diabetic retinopathy ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3825932
rs3825932
Entrez Id: 1512
Gene Symbol: CTSH
CTSH
CUI: C0154830
Disease:
Proliferative diabetic retinopathy 		0.010 GeneticVariation BEFREE We found the CTSH/rs3825932 variant (C > T) was associated with reduced risk of progression to proliferative diabetic retinopathy (PDR) (OR [95 % CI] = 0.20 [0.07-0.56], p = 2.4 × 10(-3), padjust = 0.048) and ERBB3/rs2292239 variant (G > T) associated with increased risk of two-step progression (OR [95 % CI] = 2.76 [1.31-5.80], p = 7.5 × 10(-3), padjust = 0.15). 26245339 2015