KLB, klotho beta, 152831

N. diseases: 53; N. variants: 6
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11940694
rs11940694
Entrez Id: 152831
Gene Symbol: KLB
KLB
CUI: C0202239
Disease:
Uric acid measurement (procedure)
A 0.700 GeneticVariation GWASCAT Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. 31578528 2019
dbSNP: rs11940694
rs11940694
Entrez Id: 152831
Gene Symbol: KLB
KLB
CUI: C0005845
Disease:
Blood urea nitrogen measurement
A 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
dbSNP: rs11940694
rs11940694
Entrez Id: 152831
Gene Symbol: KLB
KLB
CUI: C0001948
Disease:
Alcohol consumption
A 0.700 GeneticVariation GWASCAT Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. 28485404 2017
dbSNP: rs17618244
rs17618244
Entrez Id: 152831
Gene Symbol: KLB
KLB
CUI: C0400966
Disease:
Non-alcoholic Fatty Liver Disease
0.010 GeneticVariation BEFREE In conclusion, we showed an association between the rs17618244 KLB variant, which leads to reduced KLB expression, and the severity of NAFLD in pediatric patients. 31655133 2020
dbSNP: rs12152703
rs12152703
Entrez Id: 152831
Gene Symbol: KLB
KLB
CUI: C0028754
Disease:
Obesity
0.010 GeneticVariation BEFREE The G-allele frequency of <i>KLB</i> rs7674434 and T-allele frequency of rs12152703 were higher in the obese with NAFLD than obese without NAFLD group (<i>P</i> = 0.004 and <i>P</i> = 0.006), but the genotype distribution between two non-obese groups did not differ. 31548436 2019
dbSNP: rs12152703
rs12152703
Entrez Id: 152831
Gene Symbol: KLB
KLB
CUI: C0400966
Disease:
Non-alcoholic Fatty Liver Disease
0.010 GeneticVariation BEFREE <i>KLB</i> rs7674434 and rs12152703 had associations with alanine aminotransferase (ALT) (<i>P</i> = 0.03 and <i>P</i> = 0.04, respectively) and gamma-glutamyltransferase (<i>P</i> = 0.03 and <i>P</i> = 0.02, respectively) levels in all subjects, but the associations were especially strong with ALT in the NAFLD group (<i>P</i> = 0.005 and <i>P</i> = 0.008, respectively). 31548436 2019
dbSNP: rs7670903
rs7670903
Entrez Id: 152831
Gene Symbol: KLB
KLB
CUI: C0028754
Disease:
Obesity
0.010 GeneticVariation BEFREE The A-allele of <i>KLB</i> SNP rs7670903 correlated with higher body mass index (<i>P</i> = 0.0005), and the A-allele frequency was higher in the obese than non-obese group (<i>P</i> = 0.003). 31548436 2019
dbSNP: rs7674434
rs7674434
Entrez Id: 152831
Gene Symbol: KLB
KLB
CUI: C0400966
Disease:
Non-alcoholic Fatty Liver Disease
0.010 GeneticVariation BEFREE <i>KLB</i> rs7674434 and rs12152703 had associations with alanine aminotransferase (ALT) (<i>P</i> = 0.03 and <i>P</i> = 0.04, respectively) and gamma-glutamyltransferase (<i>P</i> = 0.03 and <i>P</i> = 0.02, respectively) levels in all subjects, but the associations were especially strong with ALT in the NAFLD group (<i>P</i> = 0.005 and <i>P</i> = 0.008, respectively). 31548436 2019
dbSNP: rs7674434
rs7674434
Entrez Id: 152831
Gene Symbol: KLB
KLB
CUI: C0028754
Disease:
Obesity
0.010 GeneticVariation BEFREE The G-allele frequency of <i>KLB</i> rs7674434 and T-allele frequency of rs12152703 were higher in the obese with NAFLD than obese without NAFLD group (<i>P</i> = 0.004 and <i>P</i> = 0.006), but the genotype distribution between two non-obese groups did not differ. 31548436 2019
dbSNP: rs1054506960
rs1054506960
Entrez Id: 152831
Gene Symbol: KLB
KLB
CUI: C1262211
Disease:
Diarrhoea predominant irritable bowel syndrome
0.010 GeneticVariation BEFREE Interaction tests of KLB rs17618244 with 3 nonsynonymous SNPs of fibroblast growth factor receptor 4 (FGFR4) revealed that rs1966265 (Val10Ile) and rs351855 (Gly388Arg) modulate rs1768244's association with colonic transit in IBS-D (P=.0025 and P=.0023, respectively). 21396369 2011
dbSNP: rs17618244
rs17618244
Entrez Id: 152831
Gene Symbol: KLB
KLB
CUI: C1262211
Disease:
Diarrhoea predominant irritable bowel syndrome
0.010 GeneticVariation BEFREE Interaction tests of KLB rs17618244 with 3 nonsynonymous SNPs of fibroblast growth factor receptor 4 (FGFR4) revealed that rs1966265 (Val10Ile) and rs351855 (Gly388Arg) modulate rs1768244's association with colonic transit in IBS-D (P=.0025 and P=.0023, respectively). 21396369 2011