ADRB2, adrenoceptor beta 2, 154

N. diseases: 387; N. variants: 17
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1042713
rs1042713
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0039494
Disease:
Temporomandibular Joint Disorders
0.010 GeneticVariation BEFREE With respect to the ADRB2 gene, the non-polymorphic AA genotype in the rs1042713 region was more prevalent in the articular TMD group than in the muscular TMD group (P= 0.05). 31285095 2020
dbSNP: rs1042711
rs1042711
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0684249
Disease:
Carcinoma of lung
0.010 GeneticVariation BEFREE Genetic model analysis shows that rs1042711 and rs1560642 were associated with increased risk of lung cancer; whereas rs7025417, rs5756523, and rs2284033 were associated with decreased disease risk (p < 0.05). 31685439 2019
dbSNP: rs1042711
rs1042711
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0242379
Disease:
Malignant neoplasm of lung
0.010 GeneticVariation BEFREE Genetic model analysis shows that rs1042711 and rs1560642 were associated with increased risk of lung cancer; whereas rs7025417, rs5756523, and rs2284033 were associated with decreased disease risk (p < 0.05). 31685439 2019
dbSNP: rs1042711
rs1042711
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C1306460
Disease:
Primary malignant neoplasm of lung
0.010 GeneticVariation BEFREE Genetic model analysis shows that rs1042711 and rs1560642 were associated with increased risk of lung cancer; whereas rs7025417, rs5756523, and rs2284033 were associated with decreased disease risk (p < 0.05). 31685439 2019
dbSNP: rs1042713
rs1042713
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0740304
Disease:
COPD exacerbation
0.010 GeneticVariation BEFREE In current users of β<sub>2</sub>-agonists, the risk of COPD exacerbation decreased by 30% (hazard ratio (HR); 0.70, 95% CI: 0.59-0.84) for each copy of the Arg allele of rs1042713 and by 20% (HR; 0.80, 95% CI: 0.69-0.94) for each copy of the Gln allele of rs1042714. 31683975 2019
dbSNP: rs1042714
rs1042714
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0740304
Disease:
COPD exacerbation
0.010 GeneticVariation BEFREE In current users of β<sub>2</sub>-agonists, the risk of COPD exacerbation decreased by 30% (hazard ratio (HR); 0.70, 95% CI: 0.59-0.84) for each copy of the Arg allele of rs1042713 and by 20% (HR; 0.80, 95% CI: 0.69-0.94) for each copy of the Gln allele of rs1042714. 31683975 2019
dbSNP: rs1042714
rs1042714
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0085207
Disease:
Gestational Diabetes
0.010 GeneticVariation BEFREE The aim of this study was to investigate the correlations and interactions between the polymorphisms of insulin resistance-related genes (ADIPOQ rs2241766), inflammation factors (TNF-α rs1800629, IL-6 rs1800795), obesity-related genes (GNB3 rs5443, ADRB rs1042714), and risk factors for gestational diabetes mellitus (GDM) such as diet structure in the development of GDM. 29519182 2019
dbSNP: rs1800888
rs1800888
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C1956346
Disease:
Coronary Artery Disease
0.010 GeneticVariation BEFREE No other significant associations were observed between ADRB1 (rs1801252, rs1801253), ADRB2 (rs1042713, rs1800888) polymorphisms and cardiovascular events or all-cause mortality in CAD patients. 30668166 2019
dbSNP: rs1042713
rs1042713
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0034067
Disease:
Pulmonary Emphysema
0.010 GeneticVariation BEFREE Combination analysis of ADRB2 Arg16Gly polymorphism and EHI% may predict the effectiveness of β<sub>2</sub>-adrenergic receptor agonist treatment in patients with COPD and emphysema. 28964817 2018
dbSNP: rs1042713
rs1042713
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0264716
Disease:
Chronic heart failure
0.010 GeneticVariation BEFREE This Arg16Gly genotype-dependent heterogeneity in clinical outcomes of HF was successfully validated in the second independent population. 30374408 2018
dbSNP: rs1042713
rs1042713
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0265706
Disease:
Gastroschisis
0.010 GeneticVariation BEFREE The rs4961 (ADD1), rs5443 (GNB3), rs1042713, and rs1042714 (ADRB2) were significantly associated with gastroschisis. 29550988 2018
dbSNP: rs1042713
rs1042713
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C3495949
Disease:
Locally advanced breast cancer
0.010 GeneticVariation BEFREE rs1042713, which is located in the <i>ADRB2</i> gene, could predict pCR to taxane-and platinum-based neoadjuvant chemotherapy in LABC. 30568487 2018
dbSNP: rs1042714
rs1042714
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0349782
Disease:
Ischemic cardiomyopathy
0.010 GeneticVariation BEFREE Polymorphism Gln27Glu of β2 Adrenergic Receptors in Patients with Ischaemic Cardiomyopathy. 28933308 2018
dbSNP: rs1042714
rs1042714
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C1299432
Disease:
Multi vessel coronary artery disease
0.010 GeneticVariation BEFREE In HF patients concerning the differences in patient characteristics between allele categories (Gln27Gln vs. Gln27Glu/Glu27Glu) there was no difference in risk factors, LVEF, treatment, the clinical status and NYHA categorization of patients, and in the prevalence of multi-vessel coronary artery disease. 28933308 2018
dbSNP: rs1042714
rs1042714
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0265706
Disease:
Gastroschisis
0.010 GeneticVariation BEFREE The rs4961 (ADD1), rs5443 (GNB3), rs1042713, and rs1042714 (ADRB2) were significantly associated with gastroschisis. 29550988 2018
dbSNP: rs2053044
rs2053044
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0042571
Disease:
Vertigo
0.010 GeneticVariation BEFREE Finally, the severity of cervical vertigo was classified according to the JOA scoring, and the recovery rate (RR) of cervical vertigo was calculated in light of the formula as: [Formula: see text] RESULTS: The SNPs within ADRA1A [rs1048101 (T>C) and rs3802241 (C>T)], NPY [rs16476 (A>C), rs16148 (T>C), and rs5574 (C>T)], ADRB1 [rs28365031 (A>G)] and ADRB2 [rs2053044 (A>G)] were all significantly associated with regulated risk of cervical vertigo (all P < .05). 29197114 2018
dbSNP: rs1042711
rs1042711
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0024117
Disease:
Chronic Obstructive Airway Disease
0.010 GeneticVariation BEFREE It is indicated that the TT genotype of rs1042711 and smoking pack years are both risk factors for COPD. 28753063 2017
dbSNP: rs1042713
rs1042713
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0041327
Disease:
Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE Genotype distributions of the rs1042713 (Arg16Gly +46A>G) and rs1042714 (Gln27Glu +79C>G) polymorphisms in ADRB2 gene in 106 patients with pulmonary tuberculosis and 88 healthy subjects were studied by PCR-RFLP method in an Iranian population. 27900465 2017
dbSNP: rs1042713
rs1042713
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0020557
Disease:
Hypertriglyceridemia
0.010 GeneticVariation BEFREE Subsequently, in the case-control study, we observed that the A46G polymorphism was significantly associated with the elevated risk of hypertriglyceridemia in the dominant model (OR: 1.47, 95%CI: 1.05-2.06, P = 0.025). 28287890 2017
dbSNP: rs1042713
rs1042713
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0041296
Disease:
Tuberculosis
0.010 GeneticVariation BEFREE The association was reported between rs1042713 and rs1042714 polymorphisms in ADRB2 gene and tuberculosis for the first time. rs1042713*G and rs1042714*G polymorphisms in ADRB2 gene makes people more susceptible to develop the disease. 27900465 2017
dbSNP: rs1042714
rs1042714
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0041296
Disease:
Tuberculosis
0.010 GeneticVariation BEFREE The association was reported between rs1042713 and rs1042714 polymorphisms in ADRB2 gene and tuberculosis for the first time. rs1042713*G and rs1042714*G polymorphisms in ADRB2 gene makes people more susceptible to develop the disease. 27900465 2017
dbSNP: rs1042714
rs1042714
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0041327
Disease:
Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE Genotype distributions of the rs1042713 (Arg16Gly +46A>G) and rs1042714 (Gln27Glu +79C>G) polymorphisms in ADRB2 gene in 106 patients with pulmonary tuberculosis and 88 healthy subjects were studied by PCR-RFLP method in an Iranian population. 27900465 2017
dbSNP: rs1042718
rs1042718
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0015672
Disease:
Fatigue
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787 2017
dbSNP: rs1042713
rs1042713
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C1706410
Disease:
Atopic IgE-mediated allergic disorder
0.010 GeneticVariation BEFREE In conclusion, a five-locus interaction exists among IL4 -590C>T, FCER1B E237G, CD14 -159C>T, IL4RA Q551R and ADRB2 R16G in Filipino cases of atopic allergy. 25876437 2015
dbSNP: rs11959427
rs11959427
Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0085580
Disease:
Essential Hypertension
0.010 GeneticVariation BEFREE While, there was no significant difference between EH group and NH in genotypes and allele frequency of rs2053044, rs12654778, rs2895795, rs17108803 and rs11959427 (P>0.05). 26339405 2015