|
rs1058172
|
CYP2D6;NDUFA6-DT
|
Major Depressive Disorder
|
|
0.700 |
GeneticVariation |
GWASCAT |
Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.
|
24528284 |
2014 |
|
rs1058172
|
CYP2D6;NDUFA6-DT
|
response to SSRI
|
|
0.700 |
GeneticVariation |
GWASCAT |
Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.
|
24528284 |
2014 |
|
rs1065852
|
CYP2D6;NDUFA6-DT;LOC112268294
|
response to SSRI
|
|
0.700 |
GeneticVariation |
GWASCAT |
Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.
|
24528284 |
2014 |
|
rs1065852
|
CYP2D6;NDUFA6-DT;LOC112268294
|
Major Depressive Disorder
|
|
0.700 |
GeneticVariation |
GWASCAT |
Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.
|
24528284 |
2014 |
|
rs1135840
|
CYP2D6;NDUFA6-DT
|
CYP2D6 polymorphism
|
|
0.030 |
GeneticVariation |
BEFREE |
The effects of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and paroxetine on dopamine formation from p-tyramine, mediated by cytochrome P450 (CYP) 2D6.2 (Arg296Cys, Ser486Thr) and CYP2D6.10 (Pro34Ser, Ser486Thr), were compared with their effects on CYP2D6.1 (wild type)-mediated dopamine formation, to investigate the influence of a CYP2D6 polymorphism on neuroactive amine metabolism in the brain.
|
31804922 |
2019 |
|
rs1135840
|
CYP2D6;NDUFA6-DT
|
CYP2D6 polymorphism
|
|
0.030 |
GeneticVariation |
BEFREE |
The inhibitory effects of antidepressants, such as imipramine, desipramine, and fluvoxamine, on dopamine formation from p-tyramine catalyzed by cytochrome P450 (CYP) 2D6.2 (Arg296Cys, Ser486Thr) and CYP2D6.10 (Pro34Ser, Ser486Thr), were compared with those on dopamine formation catalyzed by CYP2D6.1 (wild type), to investigate the effect of a CYP2D6 polymorphism on neuroactive amine metabolism in the brain.
|
29602316 |
2018 |
|
rs1135840
|
CYP2D6;NDUFA6-DT
|
CYP2D6 polymorphism
|
|
0.030 |
GeneticVariation |
BEFREE |
The inhibitory effects of steroid hormones, including glucocorticoids such as cortisol, and related compounds on dopamine formation from p-tyramine, catalyzed by cytochrome P450 (CYP) 2D6.2 (Arg296Cys, Ser486Thr) and CYP2D6.10 (Pro34Ser, Ser486Thr) were compared with the effects of those catalyzed by CYP2D6.1 (wild type), to investigate the effect of a CYP2D6 polymorphism on neuroactive amine metabolism in the brain.
|
28347660 |
2017 |
|
rs1065852
|
CYP2D6;NDUFA6-DT;LOC112268294
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Results indicate that C100T and high serum cholesterol are risk factors of ineffective endoxifen levels in Taiwanese breast cancer patients.
|
31195002 |
2019 |
|
rs1065852
|
CYP2D6;NDUFA6-DT;LOC112268294
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation |
BEFREE |
Results indicate that C100T and high serum cholesterol are risk factors of ineffective endoxifen levels in Taiwanese breast cancer patients.
|
31195002 |
2019 |
|
rs1065852
|
CYP2D6;NDUFA6-DT;LOC112268294
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
The purpose of the study was to determine the association between CYP2D6*10 (c.100C>T) genotype and attainment of the plasma steady-state Z-END minimal threshold concentration (MTC) in Indonesian women with breast cancer.
|
30843495 |
2019 |
|
rs1065852
|
CYP2D6;NDUFA6-DT;LOC112268294
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation |
BEFREE |
The purpose of the study was to determine the association between CYP2D6*10 (c.100C>T) genotype and attainment of the plasma steady-state Z-END minimal threshold concentration (MTC) in Indonesian women with breast cancer.
|
30843495 |
2019 |
|
rs1080985
|
CYP2D6;NDUFA6-DT;LOC112268294
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation |
BEFREE |
Replication study to confirm the role of CYP2D6 polymorphism rs1080985 on donepezil efficacy in Alzheimer's disease patients.
|
22465999 |
2012 |
|
rs1135840
|
CYP2D6;NDUFA6-DT
|
Intraocular pressure disorder
|
|
0.020 |
GeneticVariation |
BEFREE |
Neither rs16947 (P = 0.339) nor rs1135840 (P = 0.903) genotype was statistically correlated with the IOP-lowering effect of timolol eye drops.
|
20925579 |
2010 |
|
rs16947
|
CYP2D6;NDUFA6-DT
|
Intraocular pressure disorder
|
|
0.020 |
GeneticVariation |
BEFREE |
Neither rs16947 (P = 0.339) nor rs1135840 (P = 0.903) genotype was statistically correlated with the IOP-lowering effect of timolol eye drops.
|
20925579 |
2010 |
|
rs16947
|
CYP2D6;NDUFA6-DT
|
Glaucoma, Primary Open Angle
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs16947 genotype was significantly associated with occurrence of bradycardia in primary open-angle glaucoma patients (P = 0.021).
|
20925579 |
2010 |
|
rs1080985
|
CYP2D6;NDUFA6-DT;LOC112268294
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism rs1080985 in the CYP2D6 gene may influence the clinical efficacy of donepezil in patients with mild to moderate Alzheimer disease (AD).
|
19738170 |
2009 |
|
rs1135840
|
CYP2D6;NDUFA6-DT
|
Intraocular pressure disorder
|
|
0.020 |
GeneticVariation |
BEFREE |
According to SNP genotyping in 73 subjects, there was no significant difference of IOP between subjects with different CYP2D6 Arg296Cys (P = 0.308) or Ser486Thr genotypes (P = 0.741).
|
19284319 |
2009 |
|
rs16947
|
CYP2D6;NDUFA6-DT
|
Intraocular pressure disorder
|
|
0.020 |
GeneticVariation |
BEFREE |
According to SNP genotyping in 73 subjects, there was no significant difference of IOP between subjects with different CYP2D6 Arg296Cys (P = 0.308) or Ser486Thr genotypes (P = 0.741).
|
19284319 |
2009 |
|
rs16947
|
CYP2D6;NDUFA6-DT
|
Glaucoma, Primary Open Angle
|
|
0.020 |
GeneticVariation |
BEFREE |
CYP2D6 SNP Arg296Cys appeared to be correlative with the intersubject variability seen with timolol in POAG subjects.
|
19284319 |
2009 |
|
rs1065852
|
CYP2D6;NDUFA6-DT;LOC112268294
|
CYP2D6 polymorphism
|
|
0.010 |
GeneticVariation |
BEFREE |
The effects of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and paroxetine on dopamine formation from p-tyramine, mediated by cytochrome P450 (CYP) 2D6.2 (Arg296Cys, Ser486Thr) and CYP2D6.10 (Pro34Ser, Ser486Thr), were compared with their effects on CYP2D6.1 (wild type)-mediated dopamine formation, to investigate the influence of a CYP2D6 polymorphism on neuroactive amine metabolism in the brain.
|
31804922 |
2019 |
|
rs1065852
|
CYP2D6;NDUFA6-DT;LOC112268294
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
This study revealed that rs1065852, rs2043449, rs2762s934, and rs6068816 of CYPs were associated with LC susceptibility in the Northwestern Chinese Han population; CYP2D6 and CYP20A1 were overexpressed and correlated with prognosis of LC.
|
31264381 |
2019 |
|
rs1065852
|
CYP2D6;NDUFA6-DT;LOC112268294
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
This study revealed that rs1065852, rs2043449, rs2762s934, and rs6068816 of CYPs were associated with LC susceptibility in the Northwestern Chinese Han population; CYP2D6 and CYP20A1 were overexpressed and correlated with prognosis of LC.
|
31264381 |
2019 |
|
rs1065852
|
CYP2D6;NDUFA6-DT;LOC112268294
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
This study revealed that rs1065852, rs2043449, rs2762s934, and rs6068816 of CYPs were associated with LC susceptibility in the Northwestern Chinese Han population; CYP2D6 and CYP20A1 were overexpressed and correlated with prognosis of LC.
|
31264381 |
2019 |
|
rs1135840
|
CYP2D6;NDUFA6-DT
|
Liver Failure, Acute
|
|
0.010 |
GeneticVariation |
BEFREE |
The 2 most common variants, rs4940595 and rs1135840, of the SERPINB11 and CYP2D6 genes, respectively, found in our patients with ALF have been described as potentially important in the adaptive response combating the emergence of infectious diseases and associated with hepatotoxicity of antituberculous therapy, respectively.
|
31609742 |
2019 |
|
rs16947
|
CYP2D6;NDUFA6-DT
|
CYP2D6 polymorphism
|
|
0.010 |
GeneticVariation |
BEFREE |
The effects of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and paroxetine on dopamine formation from p-tyramine, mediated by cytochrome P450 (CYP) 2D6.2 (Arg296Cys, Ser486Thr) and CYP2D6.10 (Pro34Ser, Ser486Thr), were compared with their effects on CYP2D6.1 (wild type)-mediated dopamine formation, to investigate the influence of a CYP2D6 polymorphism on neuroactive amine metabolism in the brain.
|
31804922 |
2019 |