|
rs4151667
|
CFB;CYP21A2
|
Age related macular degeneration
|
|
0.070 |
GeneticVariation |
BEFREE |
Collectively, we demonstrated that the complement factor B genes rs641153 and rs4151667, but not rs1048709, rs2072633, rs12614, were associated with the susceptibility of age-related macular degeneration and might play predictive roles in future age-related macular degeneration diagnosis.
|
30974970 |
2019 |
|
rs4151667
|
CFB;CYP21A2
|
Age related macular degeneration
|
|
0.070 |
GeneticVariation |
BEFREE |
Here we describe a novel complotype composed of CFB (rs4151667)-CFB (rs641153)-CFH (rs800292), which is strongly associated with both AMD disease status (p = 5.84*10(-13)) and complement activation levels in vivo (p = 8.31*10(-9)).
|
27241480 |
2016 |
|
rs4151667
|
CFB;CYP21A2
|
Age related macular degeneration
|
|
0.070 |
GeneticVariation |
BEFREE |
The risk allele frequency for rs9332739 in C2 (AMD, 0.65%, control, 2.03%) and rs4151667 in CFB (AMD, 0.65%, control, 1.78%) was very low.
|
22273503 |
2012 |
|
rs4151667
|
CFB;CYP21A2
|
Age related macular degeneration
|
|
0.070 |
GeneticVariation |
BEFREE |
Our meta-analysis indicated strong protective effects of the variant alleles of four SNPs in CFB/C2 gene (rs9332739, rs547154, rs4151667, and rs641153) against AMD.
|
22440158 |
2012 |
|
rs4151667
|
CFB;CYP21A2
|
Age related macular degeneration
|
|
0.070 |
GeneticVariation |
BEFREE |
The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033).
|
19899988 |
2009 |
|
rs4151667
|
CFB;CYP21A2
|
Age related macular degeneration
|
|
0.070 |
GeneticVariation |
BEFREE |
No association with AMD was found for SNP rs9332739 (E318D) in the C2 gene or for rs4151667 (L9H), rs1048709 (R150R), rs4151659 (K565E), or rs2072633 (IVS17) in the BF gene.
|
18806293 |
2009 |
|
rs4151667
|
CFB;CYP21A2
|
Age related macular degeneration
|
|
0.070 |
GeneticVariation |
BEFREE |
We performed an association analysis between PCV and polymorphisms across the C2-CFB-RDBP-SKIV2L region in a Japanese population, genotyping 13 single nucleotide polymorphisms (SNPs) spanning this region, including rs9332739 (E318D), rs547154, rs4151667 (L9H), and rs641153 (R32Q) that are known to be associated with age-related macular degeneration (AMD).
|
19556007 |
2009 |