DCC, DCC netrin 1 receptor, 1630

N. diseases: 279; N. variants: 101
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1346972
rs1346972
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0410702
Disease:
Adolescent idiopathic scoliosis 		0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
dbSNP: rs16955886
rs16955886
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0410702
Disease:
Adolescent idiopathic scoliosis 		0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
dbSNP: rs2229080
rs2229080
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0279550
Disease:
Adult Rhabdomyosarcoma 		0.010 GeneticVariation BEFREE Reduced or absent expression and codon 201Gly/Arg polymorphism of DCC gene in rhabdomyosarcoma and Ewing's sarcoma/PNET family. 10998440 2000
dbSNP: rs1057519053
rs1057519053
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0175754
Disease:
Agenesis of corpus callosum 		T 0.700 CausalMutation CLINVAR
dbSNP: rs1057519054
rs1057519054
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0175754
Disease:
Agenesis of corpus callosum 		G 0.700 CausalMutation CLINVAR
dbSNP: rs1057519055
rs1057519055
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0175754
Disease:
Agenesis of corpus callosum 		A 0.700 CausalMutation CLINVAR
dbSNP: rs1057519056
rs1057519056
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0175754
Disease:
Agenesis of corpus callosum 		C 0.700 CausalMutation CLINVAR
dbSNP: rs1057519057
rs1057519057
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0175754
Disease:
Agenesis of corpus callosum 		A 0.700 CausalMutation CLINVAR
dbSNP: rs1555682265
rs1555682265
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0175754
Disease:
Agenesis of corpus callosum 		T 0.700 CausalMutation CLINVAR Biallelic mutations in human DCC cause developmental split-brain syndrome. 28250456 2017
dbSNP: rs199651452
rs199651452
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0175754
Disease:
Agenesis of corpus callosum 		T 0.700 CausalMutation CLINVAR
dbSNP: rs754914260
rs754914260
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0175754
Disease:
Agenesis of corpus callosum 		T 0.700 CausalMutation CLINVAR
dbSNP: rs775565634
rs775565634
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0175754
Disease:
Agenesis of corpus callosum 		A 0.700 CausalMutation CLINVAR
dbSNP: rs2229080
rs2229080
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0004364
Disease:
Autoimmune Diseases 		0.010 GeneticVariation BEFREE There was no evidence for association of DCC nt 601 C --> G with autoimmune disease in cohorts comprising 2253 subjects with rheumatoid arthritis, type I diabetes and Graves' disease, and 2225 control subjects, from New Zealand and the United Kingdom. 14571268 2003
dbSNP: rs4384683
rs4384683
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0004604
Disease:
Back Pain 		G 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain. 30261039 2018
dbSNP: rs11082953
rs11082953
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs4129322
rs4129322
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C1305855
Disease:
Body mass index 		A 0.700 GeneticVariation GWASCAT Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. 28892062 2017
dbSNP: rs9956644
rs9956644
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C1305855
Disease:
Body mass index 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs1568364038
rs1568364038
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C1855710
Disease:
Bone marrow hypocellularity 		C 0.700 GeneticVariation CLINVAR
dbSNP: rs2229080
rs2229080
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE An age-stratified analysis revealed an association between rs2229080 and reduced breast cancer risk among older patients (≥ 49 years). 27127179 2016
dbSNP: rs4078288
rs4078288
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE However, the results indicated a lack of association between rs4078288 and breast cancer risk. 27127179 2016
dbSNP: rs7504990
rs7504990
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE We observed a significantly decreased breast cancer risk with the rs7504990 C/T, T/T, and C/T-T/T genotypes, and the minor allele T was protective against breast cancer in an allele model. 27127179 2016
dbSNP: rs2229080
rs2229080
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0007097
Disease:
Carcinoma 		0.010 GeneticVariation BEFREE To elucidate further genetic alterations in flat-type colorectal tumors, codon 201Arg/Gly polymorphism in the DCC (deleted in colorectal carcinoma) gene was analyzed in normal tissue (normal colonic mucosa or peripheral lymphocytes) and in tumor tissue from 191 patients with colorectal tumors (36 patients with flat-type colorectal tumors, 81 patients with polypoid-type colorectal tumors, and 74 patients with advanced carcinomas). 9440618 1997
dbSNP: rs2229080
rs2229080
Entrez Id: 1630
Gene Symbol: DCC
DCC
CUI: C0220611
Disease:
Childhood Rhabdomyosarcoma 		0.010 GeneticVariation BEFREE Reduced or absent expression and codon 201Gly/Arg polymorphism of DCC gene in rhabdomyosarcoma and Ewing's sarcoma/PNET family. 10998440 2000
dbSNP: rs387906555
rs387906555
Entrez Id: 1630;101928167
Gene Symbol: DCC;LINC01917
DCC;LINC01917
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.800 GeneticVariation UNIPROT
dbSNP: rs387906555
rs387906555
Entrez Id: 1630;101928167
Gene Symbol: DCC;LINC01917
DCC;LINC01917
CUI: C0009402
Disease:
Colorectal Carcinoma 		A 0.800 CausalMutation CLINVAR