ACE, angiotensin I converting enzyme, 1636

N. diseases: 1082; N. variants: 82
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1267969615
rs1267969615
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0009402
Disease:
Colorectal Carcinoma
0.010 GeneticVariation BEFREE Our findings suggest that the angiotensin-converting enzyme I/D and angiotensinogen M235T polymorphisms are unlikely to correlate with colorectal cancer. 31642377 2020
dbSNP: rs1267969615
rs1267969615
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C4722085
Disease:
Malignant neoplasm of colon and/or rectum
0.010 GeneticVariation BEFREE Our findings suggest that the angiotensin-converting enzyme I/D and angiotensinogen M235T polymorphisms are unlikely to correlate with colorectal cancer. 31642377 2020
dbSNP: rs4343
rs4343
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0742343
Disease:
Acute Chest Syndrome
0.010 GeneticVariation BEFREE This study aims to investigate the impact of ACE (rs4343) and AT1R (rs 5182) genetic polymorphisms on the outcome of acute coronary syndrome (ACS) in patients on captopril. 31195108 2020
dbSNP: rs4343
rs4343
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0948089
Disease:
Acute Coronary Syndrome
0.010 GeneticVariation BEFREE This study aims to investigate the impact of ACE (rs4343) and AT1R (rs 5182) genetic polymorphisms on the outcome of acute coronary syndrome (ACS) in patients on captopril. 31195108 2020
dbSNP: rs1205538057
rs1205538057
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE G-containing genotypes (AG + GG) and G allele of AT2R in intron 1 (A1675G) were more frequent in SLE patients compared to controls ( p = 0.01, OR = 2.3, 95% CI = 1.2-4.5; p = 0.02, OR = 2.1, 95% CI = 1.2-3.7, respectively). 30621494 2019
dbSNP: rs1267969615
rs1267969615
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0410158
Disease:
Muscle damage
0.010 GeneticVariation BEFREE Muscle damage was also determined fifteen days after race and angiotensinogen (<i>AGT</i>) Met235Thr, angiotensin-converting enzyme (<i>ACE</i>) I/D, and Bradykinin B2 receptor (<i>BDKRB2</i>) -9/+9 polymorphisms were determined. 31708962 2019
dbSNP: rs1339023151
rs1339023151
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.010 GeneticVariation BEFREE The objective of this research is to study AT2R gene polymorphisms in exon 3 (C1593A) and intron 1 (A1675G) in Egyptian children with SLE and its correlation with disease manifestations and serum angiotensin-converting enzyme (ACE) level. 30621494 2019
dbSNP: rs1799752
rs1799752
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0020538
Disease:
Hypertensive disease
0.010 GeneticVariation BEFREE We did not observe associations between hypertension and rs1799752 (<i>P</i>=0.422), rs699 (<i>P</i>=0.36), rs5186 (<i>P</i>=0.49), and rs1799998 (<i>P</i>=0.71). 31511791 2019
dbSNP: rs4331
rs4331
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C4021107
Disease:
Non-obstructive azoospermia
0.010 GeneticVariation BEFREE CONCLUSIONS No significant association was found between ACE SNPs rs4316, rs4331, rs4343, or rs4362 and NOA in the Chinese Han population of Northeast China. 31198195 2019
dbSNP: rs4343
rs4343
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C4021107
Disease:
Non-obstructive azoospermia
0.010 GeneticVariation BEFREE CONCLUSIONS No significant association was found between ACE SNPs rs4316, rs4331, rs4343, or rs4362 and NOA in the Chinese Han population of Northeast China. 31198195 2019
dbSNP: rs4362
rs4362
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C4021107
Disease:
Non-obstructive azoospermia
0.010 GeneticVariation BEFREE CONCLUSIONS No significant association was found between ACE SNPs rs4316, rs4331, rs4343, or rs4362 and NOA in the Chinese Han population of Northeast China. 31198195 2019
dbSNP: rs754618480
rs754618480
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0494463
Disease:
Alzheimer Disease, Late Onset
0.010 GeneticVariation BEFREE APOE, MTHFR A1298C and BDNF C270T polymorphisms may be associated with LOAD and BDNF and MTHFR alleles may play a role in the age at onset of the LOAD. 31102717 2019
dbSNP: rs1267969615
rs1267969615
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0155626
Disease:
Acute myocardial infarction
0.010 GeneticVariation BEFREE There was a significant difference in the insertion deletion genotype distribution between two groups (P = 0.03) and a higher percentage of the T allele M235T polymorphism in the group of STEAMI patients (P = 0.02). 29474203 2018
dbSNP: rs1799752
rs1799752
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0026769
Disease:
Multiple Sclerosis
0.010 GeneticVariation BEFREE We found significant overrepresentation of the I allele of the rs1799752 in MS</span> patients compared with healthy subjects (Adjusted P value = 0.03, OR (95% CI) = 1.28 (1.05-1.57). 30218954 2018
dbSNP: rs767425642
rs767425642
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0497327
Disease:
Dementia
0.010 GeneticVariation BEFREE The association between dementia risk and all the studied polymorphisms except of PON1-Q192R was found to be significant. 28657841 2018
dbSNP: rs767425642
rs767425642
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0011265
Disease:
Presenile dementia
0.010 GeneticVariation BEFREE The association between dementia risk and all the studied polymorphisms except of PON1-Q192R was found to be significant. 28657841 2018
dbSNP: rs1267969615
rs1267969615
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0025517
Disease:
Metabolic Diseases
0.010 GeneticVariation BEFREE The aim of the study was to investigate the association between ACE (I/D) and AGT (M235T) gene polymorphisms and cardiovascular and metabolic disorders in the acromegaly. 28712073 2017
dbSNP: rs1267969615
rs1267969615
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C1861861
Disease:
CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 1 (disorder)
0.010 GeneticVariation BEFREE Also, 235TT genotype of AGT (M235T) was significantly associated with enhanced risk of the disease phenotype in HCM, DCM, and RCM. 28120210 2017
dbSNP: rs1401663578
rs1401663578
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0011265
Disease:
Presenile dementia
0.010 GeneticVariation BEFREE Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121. 28099631 2017
dbSNP: rs1401663578
rs1401663578
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0003469
Disease:
Anxiety Disorders
0.010 GeneticVariation BEFREE CETP variants that included G alleles of I422V and TaqIB were mostly associated with less intense frontally mediated behaviors, while severely impaired carriers of the T allele of rs2695121 had more anxiety and more aberrant motor behavior. 28099631 2017
dbSNP: rs1401663578
rs1401663578
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0003467
Disease:
Anxiety
0.010 GeneticVariation BEFREE CETP variants that included G alleles of I422V and TaqIB were mostly associated with less intense frontally mediated behaviors, while severely impaired carriers of the T allele of rs2695121 had more anxiety and more aberrant motor behavior. 28099631 2017
dbSNP: rs1401663578
rs1401663578
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0497327
Disease:
Dementia
0.010 GeneticVariation BEFREE Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121. 28099631 2017
dbSNP: rs1799752
rs1799752
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0497327
Disease:
Dementia
0.010 GeneticVariation BEFREE As previously found for rs1799752 in ACE, rs5186 in AGTR1 was associated with dementia at baseline (OR: 3.25 [CI: 1.42-7.06], z = 2.90, p = 0.004). 27639288 2017
dbSNP: rs1799752
rs1799752
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0011581
Disease:
Depressive disorder
0.010 GeneticVariation BEFREE The aim of the present study was to examine the influence of the well-known polymorphisms rs1799752 in the angiotensin-converting enzyme (ACE) and rs5186 in the angiotensin receptor II type 1 (AGTR1) on late-life depression and dementia in a population-based Swedish cohort of older individuals followed over 12 years. 27639288 2017
dbSNP: rs1799752
rs1799752
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0344315
Disease:
Depressed mood
0.010 GeneticVariation BEFREE The aim of the present study was to examine the influence of the well-known polymorphisms rs1799752 in the angiotensin-converting enzyme (ACE) and rs5186 in the angiotensin receptor II type 1 (AGTR1) on late-life depression and dementia in a population-based Swedish cohort of older individuals followed over 12 years. 27639288 2017