DEFB1, defensin beta 1, 1672

N. diseases: 177; N. variants: 8
Disease: Septicemia ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799946
rs1799946
Entrez Id: 1672
Gene Symbol: DEFB1
DEFB1
CUI: C0036690
Disease:
Septicemia 		0.010 GeneticVariation BEFREE Genotypes CT and TT of rs1143643 (the IL1β gene) and genotype GG of rs2664349GG (the MMP-16 gene) were associated with a significantly increased overall risk of developing sepsis (p = 0.03, p = 0.05 and p = 0.03), whereas genotypes AG of rs4358188 (the BPI gene) and CT of rs1799946 (the DEFβ1 gene) were associated with a significantly reduced risk of developing sepsis (p = 0.05 for both). 25000179 2014