rs13266634
|
SLC30A8;LOC105375716
|
Diabetes
|
|
0.100 |
GeneticVariation |
BEFREE |
Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192).
|
31823921 |
2019 |
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the diabetes risk genotype C/C at rs13266634 is associated with higher islet Zn concentration (C/C genotype: 16792 ± 1607, n = 22, C/T genotype: 11221 ± 1245, n = 18 T/T genotype: 11543 ± 6054, n = 3, all values expressed as mean nmol/g protein ± standard error of the mean, p = 0.040 by ANOVA).
|
28352089 |
2017 |
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes
|
|
0.100 |
GeneticVariation |
BEFREE |
We searched all the publications about the association between SLC30A8 and diabetes from PubMed, and evaluated the association between SLC30A8 rs13266634 C/T polymorphism and T2DM, IGT and T1DM, respectively, by meta-analysis of all the validated studies.
|
21131091 |
2011 |
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, ZnT8A-COOH-positive children who carried homozygous SLC30A8 SNP rs13266634 genotypes progressed faster to diabetes than those who were heterozygous (59% [95% CI 42.3-75.7%] vs 22% [95% CI 0-44.3%] within 5 years; p = 0.01).
|
19590848 |
2009 |
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes
|
|
0.100 |
GeneticVariation |
BEFREE |
ZnT8 Arg325Trp polymorphism influences zinc transporter expression and cytokine production in PBMCs from patients with diabetes.
|
30142362 |
2018 |
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, the common polymorphism rs13266634 was associated with lowered beta cell function and a 14% increase in diabetes abundance per risk (C) allele.
|
25287711 |
2015 |
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphism rs13266634 in SLC30A8 causes abnormal synthesis, maturation and secretion of insulin, resulting in decrease in efficiency of glucose metabolism and diabetes.
|
30633652 |
2020 |
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes
|
|
0.100 |
GeneticVariation |
BEFREE |
Zinc supplementation appears to affect the early insulin response to glucose differentially by rs13266634 genotype and could be beneficial for diabetes prevention and/or treatment for some individuals based on SLC30A8 variation.
|
25348609 |
2015 |
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between ZnT8 antibody (ZnT8A), phenotype and the genetic variant rs13266634 in the SLC30A8 gene have primarily been studied in patients with young-onset diabetes.
|
23061550 |
2013 |
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, overexpression of human ZnT8 diabetes high-risk allele R325W increased 5-HT levels relative to the low-risk allele in RIN14B cells.
|
30936149 |
2019 |
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes
|
|
0.100 |
GeneticVariation |
BEFREE |
For four candidate SNPs (rs780094, rs10830963, rs7903146, and rs4607517), the strength of association between genotype and glucose was significantly (P-interaction<0.05) different in those with and without prevalent diabetes, and for all five fasting glucose candidate SNPs (rs780094, rs10830963, rs560887, rs4607517, and rs13266634) the association with measured fasting glucose was more significant in the smaller sample without prevalent diabetes than in the larger combined sample of those with and without diabetes.
|
20839289 |
2010 |
rs4876369
|
SLC30A8;LOC105375716
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale.
|
30457165 |
2019 |