GLIS3, GLIS family zinc finger 3, 169792

N. diseases: 105; N. variants: 48
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7041847
rs7041847
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.820 GeneticVariation BEFREE With the exception of four SNPs (CMIP rs16955379, PEPD rs3786897, PSMD6 rs831571, ZFAND3 rs9470794), the other SNPs had the same direction of effect (odds ratio [OR]>1.0) as in the original reports, especially GLIS3 rs7041847 and KCNK16 rs1535500 were significantly associated with type 2 diabetes (rs1535500: p=0.005, OR=1.224, 95% CI 1.062-1.409; rs7041847: p=0.035, OR=1.118, 95% CI 1.070-1.388). 31145772 2019
dbSNP: rs7041847
rs7041847
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		G 0.820 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
dbSNP: rs7041847
rs7041847
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.820 GeneticVariation BEFREE The top signals in GLIS3 (rs7875253; P = .0004; OR = 1.23 [1.10-1.38]) and KCNK16 (rs1544050; P = .002; OR = 1.16 [1.06-1.27]) were attenuated after adjustment for the East Asian lead SNPs (rs7041847 in GLIS3; rs1535500 in KCNK16), both of which also associated with T2DM in American Indians (P = .02; OR = 1.11 [1.01-1.21]; P = .007; OR = 1.19 [1.05-1.36] respectively). 27862917 2017
dbSNP: rs7041847
rs7041847
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.820 GeneticVariation GWASDB Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. 23300278 2013
dbSNP: rs7041847
rs7041847
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.820 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. 22158537 2011
dbSNP: rs7041847
rs7041847
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.820 GeneticVariation GWASDB Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. 22158537 2011
dbSNP: rs7020673
rs7020673
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent 		0.810 GeneticVariation BEFREE Our results indicate that individually the rs7020673 and rs10758593 SNPs are not significantly associated with T1DM but seem to interact in the predisposition for this disease. 28597135 2017
dbSNP: rs7020673
rs7020673
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent 		0.810 GeneticVariation GWASDB Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 19430480 2009
dbSNP: rs7020673
rs7020673
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent 		0.810 GeneticVariation GWASCAT Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. 19430480 2009
dbSNP: rs4237150
rs4237150
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0428568
Disease:
Fasting blood glucose measurement 		0.800 GeneticVariation GWASCAT Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. 25187374 2015
dbSNP: rs10758593
rs10758593
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.800 GeneticVariation GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
dbSNP: rs10814916
rs10814916
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		C 0.800 GeneticVariation GWASDB A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. 22961080 2013
dbSNP: rs10814916
rs10814916
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		C 0.800 GeneticVariation GWASCAT A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. 22961080 2013
dbSNP: rs1571583
rs1571583
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0202230
Disease:
Thyroid stimulating hormone measurement 		A 0.800 GeneticVariation GWASDB A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. 23408906 2013
dbSNP: rs1571583
rs1571583
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0202230
Disease:
Thyroid stimulating hormone measurement 		A 0.800 GeneticVariation GWASCAT A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. 23408906 2013
dbSNP: rs10758593
rs10758593
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.800 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
dbSNP: rs10758593
rs10758593
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.800 GeneticVariation GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
dbSNP: rs4237150
rs4237150
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0428568
Disease:
Fasting blood glucose measurement 		0.800 GeneticVariation GWASDB Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. 22885924 2012
dbSNP: rs7034200
rs7034200
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C1305855
Disease:
Body mass index 		A 0.800 GeneticVariation GWASCAT A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
dbSNP: rs7034200
rs7034200
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C1305855
Disease:
Body mass index 		0.800 GeneticVariation GWASDB A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
dbSNP: rs7034200
rs7034200
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.750 GeneticVariation BEFREE Five SNPs exhibited associations with pediatric-onset T2D in the combined case-parent trio and case-control analysis: LINGO/rs10968576 (odds ratio [OR] 1.82, P = 0.003), POC5/rs2112347 (OR 1.96, P = 2.4E-5), RPS10-NUDT3/rs206936 (OR 1.40, P = 0.023), GLIS3/rs7034200 (OR 2.34, P = 1.2E-6), and VEGFA/rs6905288 (OR 1.58, P = 0.015). 30652413 2019
dbSNP: rs7034200
rs7034200
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		A 0.750 GeneticVariation GWASCAT Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. 30718926 2019
dbSNP: rs7034200
rs7034200
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.750 GeneticVariation BEFREE GLIS3 rs7034200 and GRK5 rs10886471 were significantly associated with increased T2DM risk (GLIS3 rs7034200 under dominant model: P=0.0307; GRK5 rs10886471 under recessive model: P=0.0092). 26919830 2017
dbSNP: rs7034200
rs7034200
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.750 GeneticVariation BEFREE We analyzed nine single-nucleotide polymorphisms (SNPs), including rs340874 (PROX1), rs4607517 (GCK), rs2191349 (DGKB-TMEM195), rs7034200 (GLIS3), rs10885122 (ADRA2A), rs174550 (FADS1), rs11605924 (CRY2), rs10830963 (MTNR1B) and rs35767 (IGF1). rs340874 (PROX1) and rs174550 (FADS1) were significantly associated with T2D (P=0.0078, OR: 1.12; and P=0.0071, OR: 1.12, respectively). 22992776 2012
dbSNP: rs7034200
rs7034200
Entrez Id: 169792
Gene Symbol: GLIS3
GLIS3
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.750 GeneticVariation BEFREE In addition to previously reported type 2 diabetes risk variants in TCF7L2 and SLC30A8, SNPs in ADCY5 (rs11708067) and GLIS3 (rs7034200) displayed evidence for association with type 2 diabetes, with odds ratios of 1.23 (95% CI: 1.09, 1.39; p = 9.1×10(-4)) and 1.16 (95% CI: 1.05, 1.29; p = 3.49×10(-3)) respectively. 21949744 2011