DNMT3A, DNA methyltransferase 3 alpha, 1788

N. diseases: 350; N. variants: 56
Disease: Stomach Carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs13420827
rs13420827
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
CUI: C0699791
Disease:
Stomach Carcinoma 		0.030 GeneticVariation BEFREE However, subgroup analysis revealed that, in the group aged ≤60 years, DNMT3A rs13420827 was associated with reduced gastric cancer risk, and that carrier of GC/GG genotype was associated with reduced risk of gastric cancer with low differentiation or at the T3-T4 stage. 29956566 2018
dbSNP: rs13420827
rs13420827
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
CUI: C0699791
Disease:
Stomach Carcinoma 		0.030 GeneticVariation BEFREE No significant association was found between rs13420827 genetic variants and GC prognosis. 26823816 2015
dbSNP: rs13420827
rs13420827
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
CUI: C0699791
Disease:
Stomach Carcinoma 		0.030 GeneticVariation BEFREE We found that rs16999593 in DNMT1, rs11254413 in DNMT2 and rs13420827 in DNMT3A were significantly associated with GC susceptibility (OR 1.45, 0.15, 0.66, respectively; 95% CI 1.00-2.11, p = 0.047; 0.08-0.27, p < 0.01; 0.45-0.97, p = 0.034, respectively, overdominant model). 22942708 2012