DPYD, dihydropyrimidine dehydrogenase, 1806

N. diseases: 249; N. variants: 101
Disease: Neutropenia ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801160
rs1801160
Entrez Id: 1806;100873932
Gene Symbol: DPYD;DPYD-AS1
DPYD;DPYD-AS1
CUI: C0027947
Disease:
Neutropenia 		0.040 GeneticVariation BEFREE Univariate analysis allowed the selection of c.1905+1G>A, c.2194G>A and c.2846A>T alleles as significantly associated with gastrointestinal and hematological ADRs (p < 0.05), while the c.496A>G variant showed a positive trend of association with neutropenia (p = 0.06). 30723313 2019
dbSNP: rs1801160
rs1801160
Entrez Id: 1806;100873932
Gene Symbol: DPYD;DPYD-AS1
DPYD;DPYD-AS1
CUI: C0027947
Disease:
Neutropenia 		0.040 GeneticVariation BEFREE The additional DPYD polymorphisms could enhance the prevention of fluoropyrimidine toxicity. c.2194G>A is the most frequent polymorphism and it was found to be associated with neutropenia. 30858516 2019
dbSNP: rs1801160
rs1801160
Entrez Id: 1806;100873932
Gene Symbol: DPYD;DPYD-AS1
DPYD;DPYD-AS1
CUI: C0027947
Disease:
Neutropenia 		0.040 GeneticVariation BEFREE *6 rs1801160 (FDR<0.0001), and *2A rs3918290 (FDR=0.0004) variant alleles were significantly associated with time to neutropenia. 29065426 2017
dbSNP: rs1801160
rs1801160
Entrez Id: 1806;100873932
Gene Symbol: DPYD;DPYD-AS1
DPYD;DPYD-AS1
CUI: C0027947
Disease:
Neutropenia 		0.040 GeneticVariation BEFREE Moreover, we identified a strong association of V732I with leucopenia (OR = 8.17; 95%CI 2.44 - 27.31) and neutropenia (OR=2.78; 95% CI 1.03-7.51). 19473056 2009