DRD2, dopamine receptor D2, 1813

N. diseases: 437; N. variants: 42
Disease: Schizophrenia ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1079727
rs1079727
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia 		0.020 GeneticVariation BEFREE Moreover, SCZ-associated risk alleles at rs1079727, rs1076560 and rs2283265 predicted increased D2S/D2L expression ratio (P<0.05) in control individuals. 24322206 2014
dbSNP: rs1079727
rs1079727
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
CUI: C0036341
Disease:
Schizophrenia 		0.020 GeneticVariation BEFREE The relationships between DRD2 and clinical phenotypes are of particular interest because DRD2 has been shown to associate with treatment response and prefrontal dopamine transmission.Glatt et al. reported significant associations between schizophrenia and DRD2 variants (two single-nucleotide polymorphisms (SNPs) rs1079727 and rs2283265, and two haplotypes, block 3 (rs1079727(A)-rs2440390(C)-rs2283265(G)) and block 4 (rs1801028(G)-rs1110977(A)-rs1124492(C)-rs2734841 (T))) in 2408 Han Chinese individuals in Taiwan. 23364393 2013