AHR, aryl hydrocarbon receptor, 196

N. diseases: 532; N. variants: 20
Disease: Carcinoma of lung ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2066853
rs2066853
Entrez Id: 196
Gene Symbol: AHR
AHR
CUI: C0684249
Disease:
Carcinoma of lung 		0.030 GeneticVariation BEFREE SQCC individuals with mutant genotype of rs2066853 also exhibited a protec-tive effect towards lung cancer (OR=0.30, p=0.0013). 29755293 2018
dbSNP: rs2066853
rs2066853
Entrez Id: 196
Gene Symbol: AHR
AHR
CUI: C0684249
Disease:
Carcinoma of lung 		0.030 GeneticVariation BEFREE Of all the genetic variants, XRCC1 632, GSTM1 and AhR rs2066853 was the most important determinant of overall survival of lung cancer patients CONCLUSION: Through the study we introduced the concept of polygenic approach to get an insight about the various polymorphic variants in determining cancer susceptibility. 29412865 2018
dbSNP: rs2066853
rs2066853
Entrez Id: 196
Gene Symbol: AHR
AHR
CUI: C0684249
Disease:
Carcinoma of lung 		0.030 GeneticVariation BEFREE We also observed statistically significant interaction between the polymorphism rs2066853 (p.Arg554Lys) and cumulative cigarette smoking as a discrete or continuous variable (P=0.033 and 0.019, respectively), and the Lys/Lys genotype conferred an increased risk of lung cancer in the heavy smokers (adjusted odds ratio=3.36 and 95% confidence interval=1.07-10.55). 18818557 2009