rs397514644
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
COWDEN SYNDROME 6
A
0.800
CausalMutation
CLINVAR
rs397514645
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
COWDEN SYNDROME 6
G
0.800
CausalMutation
CLINVAR
rs121434592
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Malignant neoplasm of breast
0.770
GeneticVariation
UNIPROT
rs2494732
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Cannabis use
0.040
GeneticVariation
BEFREE
Cannabis use preceding onset of psychotic disorder did interact significantly with AKT1 rs2494732 genotype to affect CPT reaction time (β=8.0, SE 3.9, p=0.037) and CPT accuracy (β=-1.2, SE 0.4, p=0.003).
21775978
2011
rs201227909
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Ki-1+ Anaplastic Large Cell Lymphoma
0.010
GeneticVariation
BEFREE
ALCL xenografts selected <i>in vivo</i> showed recurrent N1178H (5/10 mice) and G1269A (4/10 mice) mutations.
30322862
2018
rs121434592
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Proteus Syndrome
0.730
GeneticVariation
BEFREE
Proteus syndrome (PS) is an ultra-rare disease characterized by progressive, disproportionate, segmental overgrowth caused by a somatic gain-of-function mutation p.Glu17Lys in the oncogene AKT1.
31058421
2019
rs2494752
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Gastric Adenocarcinoma
0.010
GeneticVariation
BEFREE
A Functional Polymorphism (rs2494752 ) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.
26818920
2016
rs2494732
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Schizophrenia
0.030
GeneticVariation
BEFREE
A meta-analysis of the associations between genetic variants in the AKT1 gene and schizophrenia found that a single nucleotide polymorphism (SNP5; rs2494732 ) was associated with schizophrenia in Asian populations.
22150081
2013
rs1057519804
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
melanoma
T
0.700
GeneticVariation
CLINVAR
A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition.
24265152
2014
rs1130233
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Infection caused by Helicobacter pylori
0.010
GeneticVariation
BEFREE
A significant interaction existed between the AKT rs1130233 genotype and H. pylori infection in CON→AG→GC disease progression.
26317520
2015
rs121434592
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Proteus Syndrome
0.730
GeneticVariation
BEFREE
A somatic activating mutation in AKT1, c.49G>A , pGlu17Lys, that results in elevated AKT signaling in mutation-positive cells, is responsible for the mosaic overgrowth condition, Proteus syndrome .
26657992
2015
rs121434592
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Meningioma
0.020
GeneticVariation
BEFREE
A subset of meningiomas lacking NF2 alterations harbored recurrent oncogenic mutations in AKT1 (p.Glu17Lys ) and SMO (p.Trp535Leu) and exhibited immunohistochemical evidence of activation of these pathways.
23334667
2013
rs121434592
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Squamous cell carcinoma of lung
0.010
GeneticVariation
BEFREE
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung .
18256540
2008
rs2494752
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Liver carcinoma
0.010
GeneticVariation
BEFREE
Additionally, results revealed that AKT1 rs2494752</span> GG and C increased the risk factors of HCC .
30127980
2018
rs121434592
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Malignant neoplasm of pancreas
0.010
GeneticVariation
BEFREE
AKT1 (E17K ) mutation in pancreatic cancer .
18783292
2008
rs121434592
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Pancreatic carcinoma
0.010
GeneticVariation
BEFREE
AKT1 (E17K ) mutation in pancreatic cancer .
18783292
2008
rs121434592
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Malignant neoplasm of breast
0.770
GeneticVariation
BEFREE
AKT1 E17K is a bona fide oncogene in a human luminal breast cancer context.
23888070
2013
rs121434592
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Breast Carcinoma
0.060
GeneticVariation
BEFREE
AKT1 E17K is a bona fide oncogene in a human luminal breast cancer context.
23888070
2013
rs2498801
AKT1;LOC102723342
Malignant Squamous Cell Neoplasm
0.010
GeneticVariation
BEFREE
Akt1 rs2498801 is related to survival in head and neck squamous cell cancer treated with radiotherapy.
25550560
2015
rs2498801
AKT1;LOC102723342
Squamous cell carcinoma
0.010
GeneticVariation
BEFREE
Akt1 rs2498801 is related to survival in head and neck squamous cell cancer treated with radiotherapy.
25550560
2015
rs121434592
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Colorectal Carcinoma
0.030
GeneticVariation
BEFREE
AKT1 E17K in Colorectal Carcinoma Is Associated with BRAF V600E but Not MSI-H Status: A Clinicopathologic Comparison to PIK3CA Helical and Kinase Domain Mutants.
25714871
2015
rs121434592
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Sinonasal undifferentiated carcinoma
0.010
GeneticVariation
BEFREE
AKT1 E17K and KIT D816V hotspot variants were each detected in one IDH2-mutated SNUC .
28493366
2017
rs1130214
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Depressive disorder
0.020
GeneticVariation
BEFREE
AKT1 gene polymorphism rs1130214 is associated with antidepressant treatment response in patients with depressive disorders .
26515520
2016
rs121434592
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Malignant neoplasm of breast
0.770
GeneticVariation
BEFREE
AKT1 mutations (E17K ) have been found in 1.4-8% of breast cancer patients.
29086897
2018
rs121434592
×
Entrez Id:
207
Gene Symbol:
AKT1
AKT1
Breast Carcinoma
0.060
GeneticVariation
BEFREE
AKT1 mutations (E17K ) have been found in 1.4-8% of breast cancer patients.
29086897
2018