|
rs929424117
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic investigation shows that both patients were carriers of an homozygous T to C transition at the nucleotide position c.2333, causing the leucine to proline amino acid change at the position 778 (p.Leu778Pro) of the <i>ERCC5</i> gene, and resulting in an XP-G phenotype.
|
30838033 |
2019 |
|
rs1047768
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the associations between six single nucleotide polymorphisms (SNPs) in XPG (rs1047768 T>C, rs2296147 T>C, rs2227869 G>C, rs2094258 C>T, rs751402 C>T, and rs873601 G>A) and cancer risk.
|
28416771 |
2017 |
|
rs2227869
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the associations between six single nucleotide polymorphisms (SNPs) in XPG (rs1047768 T>C, rs2296147 T>C, rs2227869 G>C, rs2094258 C>T, rs751402 C>T, and rs873601 G>A) and cancer risk.
|
28416771 |
2017 |
|
rs4150351
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings suggest that genetic variation in XPG/ERCC5 may not affect the risk of SCCHN, although rs4150351 C variant genotypes were associated with an increased expression of XPG/ERCC5 mRNA and nonsignificantly decreased risk of SCCHN.
|
22108238 |
2012 |
|
rs4150351
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate logistic regression showed that only an intronic tagging SNP (rs4150351A/C) of XPG/ERCC5 was associated with a decreased risk of SCCHN (adjusted odds ratio=0.76, 95% confidence interval=0.62-0.92 for AC vs. AA; adjusted odds ratio=0.81, 95% confidence interval=0.67-0.98 for AC/CC vs. AA), but this association was nonsignificant after corrections by the permutation test (empirical P=0.105).
|
22108238 |
2012 |
|
rs873601
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.020 |
GeneticVariation |
BEFREE |
We evaluated the associations between six single nucleotide polymorphisms (SNPs) in XPG (rs1047768 T>C, rs2296147 T>C, rs2227869 G>C, rs2094258 C>T, rs751402 C>T, and rs873601 G>A) and cancer risk.
|
28416771 |
2017 |
|
rs873601
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results indicate that XPG rs873601G>A polymorphism may be associated with the risk of stomach cancer.
|
26820236 |
2016 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.040 |
GeneticVariation |
BEFREE |
Taken together, our results suggested that the <i>XPG</i> rs17655 G > C polymorphism is a low-penetrance susceptibility locus for CRC.
|
30899401 |
2019 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.040 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that the <i>XPG</i> gene rs17655 G>C polymorphism was associated with increased overall cancer risk, especially the risk of gastric cancer and colorectal cancer.
|
29779017 |
2018 |
|
rs751402
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.040 |
GeneticVariation |
BEFREE |
This meta-analysis indicates that the XPG rs751402 polymorphism may be a risk factor for GC in the Chinese population.
|
29148016 |
2018 |
|
rs2296147
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.040 |
GeneticVariation |
BEFREE |
Odds ratio (OR) and 95% confidence interval (CI) were used to assess the association between XPG polymorphisms (rs751402, rs873601, and rs2296147) and cancer risk.
|
28796034 |
2017 |
|
rs2296147
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.040 |
GeneticVariation |
BEFREE |
We evaluated the associations between six single nucleotide polymorphisms (SNPs) in XPG (rs1047768 T>C, rs2296147 T>C, rs2227869 G>C, rs2094258 C>T, rs751402 C>T, and rs873601 G>A) and cancer risk.
|
28416771 |
2017 |
|
rs751402
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.040 |
GeneticVariation |
BEFREE |
Nine case-control studies involving 3540 cases and 3953 controls were included in the meta-analysis, which revealed that the XPG rs751402 polymorphism is positively associated with GC risk and could be viewed as a risk factor of GC in three genetic models.
|
28832189 |
2017 |
|
rs751402
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.040 |
GeneticVariation |
BEFREE |
Odds ratio (OR) and 95% confidence interval (CI) were used to assess the association between XPG polymorphisms (rs751402, rs873601, and rs2296147) and cancer risk.
|
28796034 |
2017 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, our study suggests that the rs17655 polymorphism in XPG is associated with an increased risk of gastric cancer.
|
27323165 |
2016 |
|
rs2296147
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.040 |
GeneticVariation |
BEFREE |
XPG rs2296147 polymorphism could be predictive of unfavorable prognosis of CRC patients.
|
26887052 |
2016 |
|
rs2296147
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.040 |
GeneticVariation |
BEFREE |
The XPG rs2296147T>C polymorphism might be a predictive factor of prognosis in cancers patients and contribute to individual treatment in the future.
|
27588464 |
2016 |
|
rs751402
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.040 |
GeneticVariation |
BEFREE |
However, we did not observe a significant association between XPG rs2094258 and rs751402 polymorphisms and development of gastric cancer.
|
27323165 |
2016 |
|
rs17655
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, our findings suggest that XPG Asp1104His polymorphism may increase the susceptibility of CRC, especially in Asian populations.
|
25332048 |
2014 |
|
rs2094258
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.050 |
GeneticVariation |
BEFREE |
Xeroderma pigmentosum group G rs2094258 polymorphism was associated with an increased risk of GC in a Chinese population.
|
29732643 |
2018 |
|
rs2094258
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.050 |
GeneticVariation |
BEFREE |
We evaluated the associations between six single nucleotide polymorphisms (SNPs) in XPG (rs1047768 T>C, rs2296147 T>C, rs2227869 G>C, rs2094258 C>T, rs751402 C>T, and rs873601 G>A) and cancer risk.
|
28416771 |
2017 |
|
rs2094258
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.050 |
GeneticVariation |
BEFREE |
We evaluated the association of five potentially functional <i>XPG</i> polymorphisms (rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C, and rs873601 G>A) with gastric cancer susceptibility in 1142 gastric cancer cases and 1173 controls.
|
27929383 |
2016 |
|
rs2094258
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.050 |
GeneticVariation |
BEFREE |
We performed this hospital-based case-control study to evaluate the association of four potentially functional XPG polymorphisms (rs2094258 C>T, rs751402 C>T, rs2296147 T>C and rs873601G>A) with stomach cancer susceptibility.
|
26820236 |
2016 |
|
rs2094258
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.050 |
GeneticVariation |
BEFREE |
However, we did not observe a significant association between XPG rs2094258 and rs751402 polymorphisms and development of gastric cancer.
|
27323165 |
2016 |
|
rs121434571
|
ERCC5;BIVM-ERCC5
|
Xeroderma pigmentosum, group G
|
|
0.700 |
GeneticVariation |
UNIPROT |
Novel XPG (ERCC5) mutations affect DNA repair and cell survival after ultraviolet but not oxidative stress.
|
23255472 |
2013 |