DisGeNET - a database of gene-disease associations

ETS1, ETS proto-oncogene 1, transcription factor, 2113

N. diseases: 327; N. variants: 20

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs4937333

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0024141
Disease:

Lupus Erythematosus, Systemic

0.010

GeneticVariation

BEFREE

These findings suggest that the rs4937333 T allele is a risk factor for susceptibility to SLE in the studied population.

31275358

2019

dbSNP:

rs7117932

Entrez Id:	2113;105369565
Gene Symbol:	ETS1;LOC105369565

ETS1;LOC105369565

CUI:	C0751356
Disease:

Idiopathic Inflammatory Myopathies

0.010

GeneticVariation

BEFREE

Our data indicated that the rs7117932 alleles and genotypes are associated with DM and IIMs (P c = 6.0 × 10-3 and P c = 0.029; P c = 0.013 and P c = 0.019, respectively).

29030598

2017

dbSNP:

rs7117932

Entrez Id:	2113;105369565
Gene Symbol:	ETS1;LOC105369565

ETS1;LOC105369565

CUI:	C0206062
Disease:

Lung Diseases, Interstitial

0.010

GeneticVariation

BEFREE

The percentages of rs7117932 and rs6590330 SNPs were significantly greater in DM and IIM patients with interstitial lung disease (ILD) (all P c < 0.05).

29030598

2017

dbSNP:

rs1128334

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0004364
Disease:

Autoimmune Diseases

0.010

GeneticVariation

BEFREE

As a conclusion, this meta-analysis demonstrated that these 2 SNPs (rs1128334 and rs10893872) in ETS1 were associated with ADs risk.

26039128

2015

dbSNP:

rs1128334

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0042164
Disease:

Uveitis

0.010

GeneticVariation

BEFREE

Overall, our results showed that there were significant associations for rs1128334 with AD risk in 5 genetic models, both in pooled analysis and in systemic lupus erythematous (SLE) subgroup, and in 3 genetic models of the uveitis subgroup.

26039128

2015

dbSNP:

rs4937333

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0003873
Disease:

Rheumatoid Arthritis

0.010

GeneticVariation

BEFREE

Rs10893872, rs11221332 and rs4937333 are not associated with RA susceptibility and clinical features.

26241881

2015

dbSNP:

rs1128334

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0038013
Disease:

Ankylosing spondylitis

0.010

GeneticVariation

BEFREE

The SNP rs1128334 was strongly associated with AS (odds ratio 1.204, 95% confidence interval 1.06-1.37; P = 0.005).

24708692

2014

dbSNP:

rs4937333

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0038013
Disease:

Ankylosing spondylitis

0.010

GeneticVariation

BEFREE

Carriers of the haplotype TAT for rs12574073, rs1128334 and rs4937333 were associated with increased risk of AS and haplotype CGC with reduced risk as compared to controls.

24708692

2014

dbSNP:

rs1128334

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0016782
Disease:

Fuchs' heterochromic cyclitis

0.010

GeneticVariation

BEFREE

Our results suggest that the investigated three SNPs, miR-146a/rs2910164, ets-1/rs1128334, and ets-1/rs10893872, are not associated with FUS in the Han Chinese population.

22355253

2012

dbSNP:

rs11221332

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0003873
Disease:

Rheumatoid Arthritis

0.020

GeneticVariation

BEFREE

Rs10893872, rs11221332 and rs4937333 are not associated with RA susceptibility and clinical features.

26241881

2015

dbSNP:

rs11221332

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0003873
Disease:

Rheumatoid Arthritis

0.020

GeneticVariation

BEFREE

The aim of this study was to identify whether the ETS1 single nucleotide polymorphism (SNP) rs11221332, described in Caucasian subjects, plays a role in rheumatoid arthritis (RA) susceptibility.

23101665

2013

dbSNP:

rs11221357

Entrez Id:	2113;105369565
Gene Symbol:	ETS1;LOC105369565

ETS1;LOC105369565

CUI:	C0200638
Disease:

Eosinophil count procedure

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs116502295

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0869220
Disease:

Adverse effects, not elsewhere classified

0.700

GeneticVariation

GWASCAT

Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records.

30420678

2019

dbSNP:

rs11819995

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0011860
Disease:

Diabetes Mellitus, Non-Insulin-Dependent

0.700

GeneticVariation

GWASCAT

Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.

30718926

2019

dbSNP:

rs7108992

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0042834
Disease:

Vital capacity

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs8705

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0023508
Disease:

White Blood Cell Count procedure

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs11221332

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0040420
Disease:

Tonometry

0.700

GeneticVariation

GWASCAT

Genome-wide association analyses identify new loci influencing intraocular pressure.

29617998

2018

dbSNP:

rs67232546

Entrez Id:	2113;101929517
Gene Symbol:	ETS1;ETS1-AS1

ETS1;ETS1-AS1

CUI:	C0011860
Disease:

Diabetes Mellitus, Non-Insulin-Dependent

0.700

GeneticVariation

GWASCAT

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.

30054458

2018

dbSNP:

rs7924522

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0017601
Disease:

Glaucoma

0.700

GeneticVariation

GWASCAT

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.

30054594

2018

dbSNP:

rs7924522

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0040420
Disease:

Tonometry

0.700

GeneticVariation

GWASCAT

Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.

30054594

2018

dbSNP:

rs7924522

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0040420
Disease:

Tonometry

0.700

GeneticVariation

GWASCAT

Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.

29785010

2018

dbSNP:

rs7924522

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0040420
Disease:

Tonometry

0.700

GeneticVariation

GWASCAT

Genome-wide association analyses identify new loci influencing intraocular pressure.

29617998

2018

dbSNP:

rs11221332

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0021390
Disease:

Inflammatory Bowel Diseases

0.700

GeneticVariation

GWASCAT

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.

28067908

2017

dbSNP:

rs11221322

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0010346
Disease:

Crohn Disease

0.700

GeneticVariation

GWASCAT

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.

26974007

2016

dbSNP:

rs11221322

Entrez Id:	2113
Gene Symbol:	ETS1

ETS1

CUI:	C0008313
Disease:

Cholangitis, Sclerosing

0.700

GeneticVariation

GWASCAT

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.

26974007

2016