MECOM, MDS1 and EVI1 complex locus, 2122

N. diseases: 191; N. variants: 57
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs751689316
rs751689316
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0085669
Disease:
Acute leukemia 		0.010 GeneticVariation BEFREE Collaboration between AML1-D171N and Evi1 was confirmed by a BMT model where coexpression of AML1-D171N and Evi1 induced acute leukemia of the same phenotype with much shorter latencies. 18192504 2008
dbSNP: rs1290784
rs1290784
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0001948
Disease:
Alcohol consumption 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs16853173
rs16853173
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0001948
Disease:
Alcohol consumption 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs1918973
rs1918973
Entrez Id: 2122;105374205
Gene Symbol: MECOM;MECOM-AS1
MECOM;MECOM-AS1
CUI: C0001948
Disease:
Alcohol consumption 		A 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs988397
rs988397
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0001948
Disease:
Alcohol consumption 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs988398
rs988398
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0001948
Disease:
Alcohol consumption 		T 0.700 GeneticVariation GWASCAT Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. 29912962 2018
dbSNP: rs1343040
rs1343040
Entrez Id: 2122;105374205
Gene Symbol: MECOM;MECOM-AS1
MECOM;MECOM-AS1
CUI: C0005823
Disease:
Blood Pressure 		0.700 GeneticVariation GWASDB Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. 21909110 2011
dbSNP: rs419076
rs419076
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0005823
Disease:
Blood Pressure 		T 0.700 GeneticVariation GWASDB Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. 21909110 2011
dbSNP: rs9290370
rs9290370
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0005823
Disease:
Blood Pressure 		0.700 GeneticVariation GWASDB Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. 21909110 2011
dbSNP: rs73174306
rs73174306
Entrez Id: 2122;105374205
Gene Symbol: MECOM;MECOM-AS1
MECOM;MECOM-AS1
CUI: C2985280
Disease:
Blood Protein Measurement 		T 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs16853722
rs16853722
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0005845
Disease:
Blood urea nitrogen measurement 		C 0.800 GeneticVariation GWASDB Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. 22797727 2012
dbSNP: rs16853722
rs16853722
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0005845
Disease:
Blood urea nitrogen measurement 		C 0.800 GeneticVariation GWASCAT Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. 22797727 2012
dbSNP: rs16853637
rs16853637
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0005845
Disease:
Blood urea nitrogen measurement 		A 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
dbSNP: rs76272256
rs76272256
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0005845
Disease:
Blood urea nitrogen measurement 		T 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
dbSNP: rs76273615
rs76273615
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0005845
Disease:
Blood urea nitrogen measurement 		0.700 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
dbSNP: rs11718956
rs11718956
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs1997280
rs1997280
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs55641330
rs55641330
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Characterizing rare and low-frequency height-associated variants in the Japanese population. 31562340 2019
dbSNP: rs75193859
rs75193859
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Characterizing rare and low-frequency height-associated variants in the Japanese population. 31562340 2019
dbSNP: rs6774494
rs6774494
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE Our findings provide evidence that the EVI-1 rs6774494 G > A polymorphism targeted by miRNA-206/133b may contribute to the pathogenesis of BC. 24935473 2014
dbSNP: rs2421648
rs2421648
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs6770911
rs6770911
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs78307470
rs78307470
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs556915505
rs556915505
Entrez Id: 2122
Gene Symbol: MECOM
MECOM
CUI: C1292778
Disease:
Chronic myeloproliferative disorder 		0.010 GeneticVariation BEFREE The disease phenotype in Mx1-Cre, LSL-Nras(G12D) mice is attenuated compared with Mx1-Cre, LSL-Kras(G12D) mice, which die of aggressive myeloproliferative disorder by 4 months of age. 21163920 2011
dbSNP: rs1918974
rs1918974
Entrez Id: 2122;105374205
Gene Symbol: MECOM;MECOM-AS1
MECOM;MECOM-AS1
CUI: C0010068
Disease:
Coronary heart disease 		0.700 GeneticVariation GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282 2011