FABP4, fatty acid binding protein 4, 2167

N. diseases: 194; N. variants: 5
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1319351179
rs1319351179
Entrez Id: 2167;101927118
Gene Symbol: FABP4;LOC101927118
FABP4;LOC101927118
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.700 GeneticVariation UNIPROT
dbSNP: rs1054135
rs1054135
Entrez Id: 2167;101927118
Gene Symbol: FABP4;LOC101927118
FABP4;LOC101927118
CUI: C4722518
Disease:
Triple-Negative Breast Carcinoma 		0.010 GeneticVariation BEFREE Immunohistochemical staining of adipocytes adjacent to TNBC tissues showed that the expression level of FABP4 was statistically significantly lower in patients with the rs1054135-GG genotype and those in the disease-free group (P=0.0004 and P=0.0091, respectively). 26959740 2016
dbSNP: rs1054135
rs1054135
Entrez Id: 2167;101927118
Gene Symbol: FABP4;LOC101927118
FABP4;LOC101927118
CUI: C3539878
Disease:
Triple Negative Breast Neoplasms 		0.010 GeneticVariation BEFREE Immunohistochemical staining of adipocytes adjacent to TNBC tissues showed that the expression level of FABP4 was statistically significantly lower in patients with the rs1054135-GG genotype and those in the disease-free group (P=0.0004 and P=0.0091, respectively). 26959740 2016
dbSNP: rs1054135
rs1054135
Entrez Id: 2167;101927118
Gene Symbol: FABP4;LOC101927118
FABP4;LOC101927118
CUI: C0027651
Disease:
Neoplasms 		0.010 GeneticVariation BEFREE Notably, for individuals having the rs1054135 SNP with the AA/AG genotype, the magnitude of increased tumour recurrence risk for overweight patients (BMI≥25kg/m2) was significantly elevated (HR2.53; 95%CI: 1.06-6.03). 26959740 2016
dbSNP: rs1054135
rs1054135
Entrez Id: 2167;101927118
Gene Symbol: FABP4;LOC101927118
FABP4;LOC101927118
CUI: C0520679
Disease:
Sleep Apnea, Obstructive 		0.010 GeneticVariation BEFREE The presence of selective SNP (e.g., rs1054135) in the FABP4 gene may account for increased plasma FABP4 levels in the context of obesity and OSA in children. 21664182 2011
dbSNP: rs1054135
rs1054135
Entrez Id: 2167;101927118
Gene Symbol: FABP4;LOC101927118
FABP4;LOC101927118
CUI: C0028754
Disease:
Obesity 		0.010 GeneticVariation BEFREE The presence of selective SNP (e.g., rs1054135) in the FABP4 gene may account for increased plasma FABP4 levels in the context of obesity and OSA in children. 21664182 2011
dbSNP: rs16909220
rs16909220
Entrez Id: 2167;101927118
Gene Symbol: FABP4;LOC101927118
FABP4;LOC101927118
CUI: C0032460
Disease:
Polycystic Ovary Syndrome 		0.010 GeneticVariation BEFREE Three polymorphisms, rs16909225, rs3834363, and rs16909220, were identified, of which rs16909225 and rs16909220 were completely linked (r² = 1) and not associated with the development of PCOS, while the -2-bp/-2-bp genotype of rs3834363 was significantly higher in PCOS than in the controls (χ² = 7.39, df = 1, P = 0.007, OR = 1.80 95% CI: 1.18-2.75). 19844814 2009
dbSNP: rs16909225
rs16909225
Entrez Id: 2167;101927118
Gene Symbol: FABP4;LOC101927118
FABP4;LOC101927118
CUI: C0032460
Disease:
Polycystic Ovary Syndrome 		0.010 GeneticVariation BEFREE Three polymorphisms, rs16909225, rs3834363, and rs16909220, were identified, of which rs16909225 and rs16909220 were completely linked (r² = 1) and not associated with the development of PCOS, while the -2-bp/-2-bp genotype of rs3834363 was significantly higher in PCOS than in the controls (χ² = 7.39, df = 1, P = 0.007, OR = 1.80 95% CI: 1.18-2.75). 19844814 2009
dbSNP: rs3834363
rs3834363
Entrez Id: 2167;101927118
Gene Symbol: FABP4;LOC101927118
FABP4;LOC101927118
CUI: C0032460
Disease:
Polycystic Ovary Syndrome 		0.010 GeneticVariation BEFREE Three polymorphisms, rs16909225, rs3834363, and rs16909220, were identified, of which rs16909225 and rs16909220 were completely linked (r² = 1) and not associated with the development of PCOS, while the -2-bp/-2-bp genotype of rs3834363 was significantly higher in PCOS than in the controls (χ² = 7.39, df = 1, P = 0.007, OR = 1.80 95% CI: 1.18-2.75). 19844814 2009