rs12526453
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Myocardial Infarction
C
0.820
GeneticVariation
GWASCAT
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
19198609
2009
rs12526453
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
0.820
GeneticVariation
BEFREE
Five single-nucleotide polymorphisms, rs4977574 (CDKN2A/2B), rs12526453 (PHACTR1), rs646776 (CELSR2-PSRC1-SORT1), rs2259816 (HNF1A), and rs11206510 (PCSK9) showed directionally consistent associations with CHD in the 3 studies, with combined odds ratios (ORs) ranging from 1.17 to 1.25 (p = 0.03 to 0.0002).
22152955
2011
rs12526453
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
C
0.820
GeneticVariation
GWASCAT
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
21378990
2011
rs12526453
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
0.820
GeneticVariation
BEFREE
Recent genome-wide association studies (GWAS) in European populations have indicated that the rs12526453 polymorphism located in phosphatase and actin regulator 1 gene (PHACTR1), mapping to chromosome 6p24 and rs7865618 polymorphism in the cyclin-dependent kinase inhibitor B antisense RNA 1 gene (CDKN2B-AS1) on 9p21.3 are associated with coronary heart disease (CHD ).
28287809
2017
rs12526453
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
C
0.820
GeneticVariation
GWASDB
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
21378990
2011
rs12526453
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Myocardial Infarction
0.820
GeneticVariation
BEFREE
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453 , P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI /CAD risk alleles increasing the degree of arterial calcification.
23561647
2013
rs12526453
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Myocardial Infarction
C
0.820
GeneticVariation
GWASDB
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
19198609
2009
rs12526453
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Myocardial Infarction
0.820
GeneticVariation
BEFREE
The rs12526453 CC homozygotes (previously associated with increased risk of myocardial infarction ) showed, in 2 independent samples, better long-term survival.
26086777
2015
rs12526453
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
0.820
GeneticVariation
GWASDB
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
21347282
2011
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
G
0.820
GeneticVariation
GWASCAT
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
22751097
2012
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
0.820
GeneticVariation
GWASDB
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
21378988
2011
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
G
0.820
GeneticVariation
GWASDB
Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis.
22745674
2012
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
0.820
GeneticVariation
BEFREE
Phosphatase and actin regulator 1 rs9349379 polymorphism is associated with an elevated susceptibility to coronary artery disease : a meta-analysis.
31278837
2019
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
0.820
GeneticVariation
GWASCAT
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
21378988
2011
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
0.820
GeneticVariation
GWASCAT
A genome-wide association study in europeans and South asians identifies 5 new Loci for coronary artery disease.
21846871
2011
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
G
0.820
GeneticVariation
GWASCAT
Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis.
22745674
2012
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
G
0.820
GeneticVariation
GWASDB
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
22751097
2012
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
0.820
GeneticVariation
GWASDB
A genome-wide association study in europeans and South asians identifies 5 new Loci for coronary artery disease.
21846871
2011
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
0.820
GeneticVariation
BEFREE
The top variant, rs9349379 , is intronic to PHACTR1, a risk locus for coronary artery disease , migraine, and cervical artery dissection.
27792790
2016
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Common Migraine
A
0.810
GeneticVariation
GWASCAT
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.
27322543
2016
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Common Migraine
0.810
GeneticVariation
BEFREE
Significant heterogeneity of SNP effects (p het < 1.4 × 10(-3)) was observed between the MA and MO subgroups (for SNP rs9349379 ), and between the clinic- and population-based subgroups (for SNPs rs10915437, rs6790925 and rs6478241).
25179292
2015
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Common Migraine
0.810
GeneticVariation
GWASDB
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
23793025
2013
rs1332844
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
T
0.800
GeneticVariation
GWASCAT
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
21378988
2011
rs1332844
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Coronary heart disease
T
0.800
GeneticVariation
GWASDB
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
21378988
2011
rs9349379
×
Entrez Id:
221692
Gene Symbol:
PHACTR1
PHACTR1
Migraine Disorders
0.800
GeneticVariation
GWASCAT
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
22683712
2012