Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.770 GeneticVariation BEFREE This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk. 27966449 2017
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.770 GeneticVariation BEFREE Significant associations with breast cancer risk were observed for rs2420946, rs2981579, and rs2981582 with OR (95% CI) per risk allele of 1.19 (1.03-1.39), 1.24 (1.07-1.43), and 1.17 (1.01-1.36), respectively. 26421298 2015
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.770 GeneticVariation BEFREE In the haplotype analysis, the FGFR2 rs2981582 T / rs2420946 T / rs1219648 G haplotype (ht2) was associated with a significantly increased BC risk compared with the rs2981582 C / rs2420946 C / rs1219648 A haplotype in familial BC and in non-familial early-onset BC (OR = 1.32, 95 % CI 1.06-1.65, P = 0.012; OR = 1.46, 95 % CI 1.11-1.91, P = 0.004, respectively). 23225170 2013
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.770 GeneticVariation BEFREE To investigate this inconsistency, we performed a meta-analysis of 37 studies involving a total of 288,142 subjects for rs2981582, rs1219648, and rs2420946 polymorphism of the FGFR2 gene to evaluate the effect of FGFR2 on genetic susceptibility for BC. 23184080 2013
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.770 GeneticVariation BEFREE Three commonly studied FGFR2 polymorphisms including rs1219648 (A > G), rs2420946 (C > T), and rs2981582 (C > T) were selected to explore their association with risk of development of breast cancer by meta-analysis of published case-control studies. 20300826 2010
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.770 GeneticVariation BEFREE In conclusion, this meta-analysis suggests that rs2981582, rs1219648, and rs2420946 polymorphisms in FGFR2 are associated with elevated BC risk. 20364400 2010
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.770 GeneticVariation BEFREE We observed a statistically significant association between 4 SNPs and breast cancer risk and these 4 SNPs were in strong linkage disequilibrium in the Japanese population. rs2420946 was associated with a population-attributable risk of 17.7%. 19582883 2009
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.770 GeneticVariation GWASDB Genome-wide association study identifies novel breast cancer susceptibility loci. 17529967 2007
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.770 GeneticVariation GWASDB A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. 17529973 2007