Variant Gene Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2981582
rs2981582
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE We conducted a literature review to identify case-control studies of variants in 4 genes known to affect breast cancer risk: CHEK2*1100delC; multiple variants in BRCA1 and BRCA2; and FGFR2 rs2981582. 20299982 2010
dbSNP: rs2981582
rs2981582
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Odds ratios for breast cancer were greatest for FGFR2-rs2981582 and TNRC9-rs3803662 and, for these 2 SNPs, were significantly greater for estrogen receptor (ER)-positive than for ER-negative disease, both in our data and in meta-analyses of all published data (pooled per-allele ORs [95% confidence intervals] for ER-positive vs ER-negative disease: 1.30 [1.26-1.33] vs 1.05 [1.01-1.10] for FGFR2; interaction P < .001; and 1.24 [1.21-1.28] vs 1.12 [1.07-1.17] for TNRC9; interaction P < .001). 20664043 2010
dbSNP: rs2981582
rs2981582
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE The study by Easton et al reported two FGFR2 SNPs, rs2981582 and rs7895676, to be among those most strongly associated with BC risk. 19536173 2010
dbSNP: rs2981582
rs2981582
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE We tested gene-environment interactions in 7610 women who developed breast cancer and 10 196 controls without the disease, studying the effects of 12 polymorphisms (FGFR2-rs2981582, TNRC9-rs3803662, 2q35-rs13387042, MAP3K1-rs889312, 8q24-rs13281615, 2p-rs4666451, 5p12-rs981782, CASP8-rs1045485, LSP1-rs3817198, 5q-rs30099, TGFB1-rs1982073, and ATM-rs1800054) in relation to prospectively collected information about ten established environmental risk factors (age at menarche, parity, age at first birth, breastfeeding, menopausal status, age at menopause, use of hormone replacement therapy, body-mass index, height, and alcohol consumption). 20605201 2010
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE An interaction was observed between combined hormone replacement therapy use and FGFR2 rs1219648 genotypes on breast cancer risk in EA women (P = 0.010). 19028704 2009
dbSNP: rs2981582
rs2981582
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE FGFR2 rs1219648 and rs2981582 genotypes were significantly associated with breast cancer in EA only in estrogen receptor-positive (ER+), progesterone receptor-positive (PR+) and HER2/Neu-negative (HER2-) tumors. 19028704 2009
dbSNP: rs2981582
rs2981582
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE The known breast cancer SNPs rs13281615, rs2981582 and rs3803662 were confirmed as associated with breast cancer risk (P (allelic test) = 1.8 x 10(-2), OR = 1.17; P (allelic test) = 2.2 x 10(-3), OR = 1.22; P (allelic test) = 5.1 x 10(-2), OR = 1.15, respectively) in the West of Ireland cohort. 19005751 2009
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE We genotyped 13 single nucleotide polymorphisms (SNPs) densely covering a 27 kb region within intron 2 of FGFR2 including two SNPs (rs2981582 and rs1219648) significantly associated with breast cancer and a total 40 tagSNPs across 150 kb of the FGFR2 gene. 18285324 2008
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE Genetic variation in FGFR2, identified by rs1219648, may account for a substantial fraction of breast cancer in Arab (12%), Ashkenazi (15%), and Sephardi Jewish (22%) populations. 18483326 2008
dbSNP: rs2981582
rs2981582
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE We genotyped 13 single nucleotide polymorphisms (SNPs) densely covering a 27 kb region within intron 2 of FGFR2 including two SNPs (rs2981582 and rs1219648) significantly associated with breast cancer and a total 40 tagSNPs across 150 kb of the FGFR2 gene. 18285324 2008
dbSNP: rs2981582
rs2981582
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE We also noted a correlation between the number of minor alleles of rs2981582 in FGFR2 and the average number of first-degree and second-degree relatives with breast cancer and/or ovarian cancer (P = 0.05). 17997823 2008
dbSNP: rs2981582
rs2981582
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.100 GeneticVariation BEFREE The minor alleles of SNP rs2981582 and rs889312 were each associated with increased breast cancer risk in BRCA2 mutation carriers (per-allele hazard ratio [HR] = 1.32, 95% CI: 1.20-1.45, p(trend) = 1.7 x 10(-8) and HR = 1.12, 95% CI: 1.02-1.24, p(trend) = 0.02) but not in BRCA1 carriers. rs3803662 was associated with increased breast cancer risk in both BRCA1 and BRCA2 mutation carriers (per-allele HR = 1.13, 95% CI: 1.06-1.20, p(trend) = 5 x 10(-5) in BRCA1 and BRCA2 combined). 18355772 2008
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.060 GeneticVariation BEFREE In the haplotype analysis, the FGFR2 rs2981582 T / rs2420946 T / rs1219648 G haplotype (ht2) was associated with a significantly increased BC risk compared with the rs2981582 C / rs2420946 C / rs1219648 A haplotype in familial BC and in non-familial early-onset BC (OR = 1.32, 95 % CI 1.06-1.65, P = 0.012; OR = 1.46, 95 % CI 1.11-1.91, P = 0.004, respectively). 23225170 2013
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.060 GeneticVariation BEFREE To investigate this inconsistency, we performed a meta-analysis of 37 studies involving a total of 288,142 subjects for rs2981582, rs1219648, and rs2420946 polymorphism of the FGFR2 gene to evaluate the effect of FGFR2 on genetic susceptibility for BC. 23184080 2013
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.060 GeneticVariation BEFREE Three commonly studied FGFR2 polymorphisms including rs1219648 (A > G), rs2420946 (C > T), and rs2981582 (C > T) were selected to explore their association with risk of development of breast cancer by meta-analysis of published case-control studies. 20300826 2011
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.060 GeneticVariation BEFREE In conclusion, this meta-analysis suggests that rs2981582, rs1219648, and rs2420946 polymorphisms in FGFR2 are associated with elevated BC risk. 20364400 2011
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.060 GeneticVariation BEFREE FGFR2 haplotypes based upon rs11200014, rs2981579, rs1219648 and rs2420946 were associated with increased risk of breast cancer, including the GTGT haplotype in AAs [OR = 1.27, 95% confidence interval (CI) 1.04-1.56] and younger women of either race [OR = 1.35, 95% CI 1.02-1.78) and the ATGT haplotype in Whites (OR = 1.30, 95% CI 1.15-1.46). 20554749 2010
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.060 GeneticVariation BEFREE We observed a statistically significant association between 4 SNPs and breast cancer risk and these 4 SNPs were in strong linkage disequilibrium in the Japanese population. rs2420946 was associated with a population-attributable risk of 17.7%. 19582883 2009
dbSNP: rs2981578
rs2981578
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.040 GeneticVariation BEFREE Thus, the apparent increased risk of developing ERα positive breast cancer seems not to be caused by rs2981578 alone. 24265722 2014
dbSNP: rs2981578
rs2981578
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.040 GeneticVariation BEFREE Results from the current meta-analysis indicates that three novel functional polymorphisms (rs11200014, rs2981579, and rs2981578) in the promoter of FGFR2 gene are associated with breast cancer susceptibility and might be a potential biomarkers for breast cancer risk. 23124475 2013
dbSNP: rs2981579
rs2981579
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.040 GeneticVariation BEFREE Results from the current meta-analysis indicates that three novel functional polymorphisms (rs11200014, rs2981579, and rs2981578) in the promoter of FGFR2 gene are associated with breast cancer susceptibility and might be a potential biomarkers for breast cancer risk. 23124475 2013
dbSNP: rs2981579
rs2981579
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.040 GeneticVariation BEFREE Four SNPs mapped to 10q26.13/FGFR2 were associated with increased breast cancer risk via an additive model with per-allelic risks (95 % CI) of 1.26 (1.12-1.43) at rs1219648, 1.22 (1.07-1.38) at rs2981582, 1.21 (1.07-1.36) at rs2981579, and 1.18 (1.04-1.35) at rs11200014. 22965832 2013
dbSNP: rs2981578
rs2981578
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.040 GeneticVariation BEFREE Our results suggest that the increased breast cancer risk associated with SNP rs2981578 is due to increased FGFR2 signaling activity in stromal fibroblasts, possibly also involving paracrine FGF10 signaling. 21767389 2012
dbSNP: rs2981579
rs2981579
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.040 GeneticVariation BEFREE A dose-dependent association was observed between the risk of breast cancer and the genetic risk score, which was an aggregate measure of alleles in seven selected variants, namely FGFR2-rs2981579, TOX3/TNRC9-rs3803662, C6orf97-rs2046210, 8q24-rs13281615, SLC4A7-rs4973768, LSP1-rs38137198, and CASP8-rs10931936. 22160591 2012
dbSNP: rs2981579
rs2981579
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0006142
Disease:
Malignant neoplasm of breast
0.040 GeneticVariation BEFREE FGFR2 haplotypes based upon rs11200014, rs2981579, rs1219648 and rs2420946 were associated with increased risk of breast cancer, including the GTGT haplotype in AAs [OR = 1.27, 95% confidence interval (CI) 1.04-1.56] and younger women of either race [OR = 1.35, 95% CI 1.02-1.78) and the ATGT haplotype in Whites (OR = 1.30, 95% CI 1.15-1.46). 20554749 2010